Reduced structural and functional skin capillaries in familial combined hyperlipidemia affected men, associated with increased remnant-like lipoprotein cholesterol levels

Reduced structural and functional skin capillaries in familial combined hyperlipidemia affected men, associated with increased remnant-like lipoprotein cholesterol levels

We determined whether abnormalities in the number of basal (BC) and post-occlusive (POC) capillaries are present in familial combined hyperlipidemia (FCHL), and investigated the possible relationship of BC and POC with lipids, remnant-like lipoprotein particles (RLP-C), blood pressure, and insulin r...

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Bibliographic Details
Published in:Atherosclerosis Vol. 163; no. 2; pp. 355 - 362
Main Authors: Keulen, Eric T.P., Schaper, Nicolaas C., Houben, Alphons J.H.M., van Lin, Josephine M.J.P., Lutgens, Isabelle, Rijkers, Kim, Dallinga-Thie, Geesje M., de Bruin, Tjerk W.A.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier Ireland Ltd 01-08-2002
Elsevier
Subjects:
Adult
Biological and medical sciences
Capillaries - physiopathology
Capillary density
Cholesterol - blood
Disorders of blood lipids. Hyperlipoproteinemia
Familial combined hyperlipidemia
Female
Humans
Hyperlipidemia, Familial Combined - blood
Hyperlipidemia, Familial Combined - pathology
Hyperlipidemia, Familial Combined - physiopathology
Insulin resistance
Lipoproteins - blood
Male
Medical sciences
Metabolic diseases
Microcirculation
Middle Aged
Multivariate Analysis
Remnant-like lipoprotein particles
Sex Characteristics
Skin - blood supply
Triglycerides - blood
Microcirculation
Insulin resistance
Familial combined hyperlipidemia
Remnant-like lipoprotein particles
Capillary density
Human
Pathophysiology
Family study
Sex
Metabolic diseases
Exploration
Lipids
Male
Lipoprotein
Phenotype
Female
Blood capillary
Hyperlipemia
Skin
Dyslipemia
Comparative study
Structural analysis
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Summary:We determined whether abnormalities in the number of basal (BC) and post-occlusive (POC) capillaries are present in familial combined hyperlipidemia (FCHL), and investigated the possible relationship of BC and POC with lipids, remnant-like lipoprotein particles (RLP-C), blood pressure, and insulin resistance. Fifty age-matched subjects, 23 (12 men) hyperlipidemic, normotensive FCHL subjects and 27 (14 men) healthy controls participated in this study. Capillary density was measured just above the finger nailfold, before and after 4 min of arterial occlusion. The number of BC and POC were significantly lower in FCHL men compared with healthy men, 113.7±15.1 versus 132.0±18.0 ( P=0.02) and 123±19.1 versus 142.3±18.3 ( P=0.03), respectively. No differences were found between FCHL women and control women. In univariate analyses in FCHL men, BC was inversely correlated with total cholesterol ( r=−0.63; P=0.05). POC tended to be inversely correlated with total cholesterol ( r=−0.62; P=0.056). No univariate correlations ( P>0.3) were observed between BC or POC and blood pressure or insulin resistance. Multivariate analyses revealed that log RLP-C was the only significant independent contributor to BC and POC. This is the first description of a reduction in skin capillaries in FCHL men, which was associated with increased atherogenic lipoprotein levels. Loss of capillary surface may be important in the pathophysiology or can result from adaptation to the hyperlipidemia in FCHL.
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ISSN:0021-9150
1879-1484
DOI:10.1016/S0021-9150(02)00021-7