Search Results - "Lustig, Kurt"

Lassa antiviral LHF-535 protects guinea pigs from lethal challenge by Cashman, Kathleen A., Wilkinson, Eric R., Posakony, Jeffrey, Madu, Ikenna G., Tarcha, Eric J., Lustig, Kurt H., Korth, Marcus J., Bedard, Kristin M., Amberg, Sean M.

“…LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates…”
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Coadministration of LHF-535 and favipiravir protects against experimental Junín virus infection and disease by Westover, Jonna B., Bailey, Kevin W., Wasson, Samantha R., Boardman, Kirsten M., Lustig, Kurt H., Amberg, Sean M., Gowen, Brian B.

“…Argentine hemorrhagic fever, caused by Junín virus (JUNV), is the most common of the South American arenaviral hemorrhagic fevers. The disease has a case…”
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1357 CD27 is a new promising T cell co-stimulatory target for the cancer immunotherapy – development and selection of a lead anti-CD27 agonist antibody by Iadonato, Shawn, Ovechkina, Yulia, Lustig, Kurt, Guillaudeux, Thierry

“…BackgroundMembers of the tumor necrosis factor receptor superfamily (TNFRSF) are key co-stimulators of T cells. CD27, a member of the TNFRSF, is expressed only…”
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A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors by Iadonato, Shawn, Ovechkina, Yulia, Lustig, Kurt, Cross, Jessica, Eyde, Nathan, Frazier, Emily, Kabi, Neda, Katz, Chen, Lance, Remington, Peckham, David, Sridhar, Shaarwari, Talbaux, Carla, Tihista, Isabelle, Xu, Mei, Guillaudeux, Thierry

“…Immune checkpoint therapies have led to significant breakthroughs in cancer patient treatment in recent years. However, their efficiency is variable, and…”
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780 VISTA-101 – A phase 1/2 clinical trial of KVA12123, an engineered IgG1 targeting VISTA, alone and in combination with pembrolizumab in advanced solid tumors by Iadonato, Shawn, Ovechkina, Yulia, Lustig, Kurt, Hayreh, Vinny, Guillaudeux, Thierry

“…BackgroundMultiple cancer immunotherapies of T-cell checkpoint inhibitors have been approved worldwide. However, most patients with advanced solid tumors do…”
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Corrigendum: A highly potent anti-VISTA antibody KVA12123 - a new immune checkpoint inhibitor and a promising therapy against poorly immunogenic tumors by Iadonato, Shawn, Ovechkina, Yulia, Lustig, Kurt, Cross, Jessica, Eyde, Nathan, Frazier, Emily, Kabi, Neda, Katz, Chen, Lance, Remington, Peckham, David, Sridhar, Shaarwari, Talbaux, Carla, Tihista, Isabelle, Xu, Mei, Guillaudeux, Thierry

“…[This corrects the article DOI: 10.3389/fimmu.2023.1311658.]…”
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A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation by Scalley-Kim, Michelle L, Hess, Bruce W, Kelly, Ryan L, Krostag, Anne-Rachel F, Lustig, Kurt H, Marken, John S, Ovendale, Pamela J, Posey, Aaron R, Smolak, Pamela J, Taylor, Janelle D L, Wood, C L, Bienvenue, David L, Probst, Peter, Salmon, Ruth A, Allison, Daniel S, Foy, Teresa M, Raport, Carol J

“…Chemokines play a key role in leukocyte recruitment during inflammation and are implicated in the pathogenesis of a number of autoimmune diseases. As such,…”
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Long-term Suppression of Experimental Arthritis Following Intramuscular Administration of a Pseudotyped AAV2/1-TNFR:Fc Vector by Sandalon, Ziv, Bruckheimer, Elizabeth M, Lustig, Kurt H, Burstein, Haim

“…We previously reported that administration of an adeno-associated virus 2 (AAV2) vector encoding a rat tumor necrosis factor (TNF) receptor–immunoglobulin Fc…”
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Secretion of a TNFR:Fc Fusion Protein following Pulmonary Administration of Pseudotyped Adeno-Associated Virus Vectors by SANDALON, Ziv, BRUCKHEIMER, Elizabeth M, LUSTIG, Kurt H, ROGERS, Linda C, PELUSO, Richard W, BURSTEIN, Haim

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Thalamocortical connections in the pond turtle Pseudemys scripta elegans by Zhu, Dantong, Lustig, Kurt H, Bifulco, Katherine, Keifer, Joyce

“…Thalamocortical connections are a neuroanatomical feature shared among vertebrates, although the extent and organization of these connections vary among…”
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Abstract 1637: A fully human anti-vista antibody as a promising therapy against poorly immunogenic tumors by Guillaudeux, Thierry, Tarcha, Eric, Bader, Robert, Dutzar, Benjamin, Eyde, Nathan, Frazier, Emily, Jurchen, David, Lance, Remington, Loomis, Cristina, Lustig, Kurt, Ovechkina, Yulia, Peckham, David, Posakony, Jeff, Sridhar, Shaarwari, Xu, Mei, Iadonato, Shawn

“…Abstract V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is an immune checkpoint regulator of the B7 family. VISTA can be found on the…”
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Abstract CT068: Interim results of the ongoing phase 1-2 clinical trial of KVA12123, an engineered IgG1 targeting VISTA, as monotherapy and in combination with pembrolizumab in patients with advanced solid tumors by Yu, Evan Y., Henry, Jason, Patel, Manish R., Swiecicki, Paul, Micaily, Ida, Garmezy, Benjamin, Banda, Kalyan, Hayreh, Vinny, Lustig, Kurt, Ovechkina, Yulia, Iadonato, Shawn P., Guillaudeux, Thierry, Rosen, Lee

“…Abstract V-domain Ig Suppressor of T-cell Activation (VISTA), a promising immuno-oncology target, is primarily expressed by immunosuppressive myeloid cells…”
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Abstract 4261: CD27 a new immuno-oncology target shaping innate and adaptive anti-tumor immune responses by Guillaudeux, Thierry, Ovechkina, Yulia, Sridhar, Shaarwari, Peckham, David, Cross, Jessica, Eyde, Nathan, Frazier, Emily, Kabi, Neda, Lance, Remington, Lustig, Kurt, Xu, Mei, Eric, Tarcha, Iadonato, Shawn

“…Abstract CD27 is a member of the TNF-receptor superfamily, highly expressed on CD4+ and CD8+ T cells as well as on NK and NKT cells. It plays a key role on T…”
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Abstract 972: VISTA expression in patients with advanced solid tumors: A potential biomarker in VISTA-101 clinical trial by Kabi, Neda, Katz, Chen, Lance, Remington, Cross, Jessica, Eyde, Nathan, Frazier, Emily, Lustig, Kurt, Ovechkina, Yulia, Peckham, David, Sridhar, Shaarwari, Talbaux, Carla, Tihista, Isabelle, Xu, Mei, Iadonato, Shawn, Guillaudeux, Thierry

“…Abstract V-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family member highly expressed on circulating and intra-tumoral myeloid…”
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182 Highly potent fully human anti-VISTA antibodies – a new target checkpoint inhibitor against immunosuppressive myeloid cells by Guillaudeux, Thierry, Tarcha, Eric, Bader, Robert, Dutzar, Benjamin, Eyde, Nathan, Frazier, Emily, Jurchen, David, Remington, Lance, Loomis, Cristina, Lustig, Kurt, Ovechkina, Yulia, Peckham, David, Shaarwari Sridhar, Xu, Mei, Iadonato, Shawn, Posakony, Jeff

“…BackgroundV-domain Immunoglobulin Suppressor of T cell Activation (VISTA/PD-1H) is a B7 family ligand expressed on circulating and intratumoural myeloid cells…”
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AAV2 1-TNFR:Fc gene delivery prevents periodontal disease progression by Cirelli, J A, Park, C H, MacKool, K, Taba, M, Lustig, K H, Burstein, H, Giannobile, W V

“…Periodontal disease is a chronic inflammatory condition induced by tooth-associated microbial biofilms that induce a host immune response. Therapeutic control…”
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578. Suppression of Inflammation Following Intramuscular Administration of Pseudotyped AAV-TNFR:Fc Vectors in a Rat Model of Arthritis by Burstein, Haim, Lustig, Kurt, Sandalon, Ziv

“…TNF-α antagonists such as anti-TNF-α monoclonal antibodies or soluble tumor necrosis factor receptor have proven to be useful therapeutics for the treatment of…”
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983. Repeat Intra-Articular Administration of AAV2 Vectors to Rat Joints by Burstein, Haim, Lustig, Kurt, Sandalon, Ziv

“…Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial inflammation, leading to the destruction of cartilage and bone. Previously, we…”
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499. Improving the Stability of Ad-AAV Hybrid Vectors by Burstein, Haim, Peluso, Richard, Sandalon, Ziv, Lustig, Kurt, Stepan, Tony

“…The Ad/AAV hybrid vector is an E1 gene-deleted adenovirus containing a transgene cassette flanked on its 5' and 3' ends by AAV ITR vector sequences. After…”
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99. Long-term Expression of Soluble TNFR:Fc Protein Following Multiple Administrations of AAV-TNFR:Fc Vector Pseudotyped with Capsids of Alternate Serotypes by Sandalon, Ziv, Lustig, Kurt, Burstein, Haim

“…Recently, we have demonstrated that local (intraarticular) or systemic (intramuscular) administration of an AAV-ratTNFR:Fc vector, encoding the rat tumor…”
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