Search Results - "Lustig, K D"

Identification of a Nuclear Receptor for Bile Acids by Makishima, Makoto, Okamoto, Arthur Y., Repa, Joyce J., Tu, Hua, Learned, R. Marc, Luk, Alvin, Hull, Mitchell V., Lustig, Kevin D., Mangelsdorf, David J., Shan, Bei

“…Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here…”
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Expression Cloning of an ATP Receptor from Mouse Neuroblastoma Cells by Lustig, Kevin D., Shiau, Andrew K., Brake, Anthony J., Julius, David

“…Extracellular ATP activates cell-surface metabotropic and ionotropic nucleotide (P2) receptors in vascular, neural, connective, and immune tissues. These…”
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Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation by Lustig, K D, Kroll, K L, Sun, E E, Kirschner, M W

“…We have used a functional assay to identify a putative T-box transcription factor (Xombi) that has the ability to induce sites of invagination in the ectoderm…”
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Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor by ERB, L, LUSTIG, K. D, SULLIVAN, D. M, TURNER, J. T, WEISMAN, G. A

“…ATP and UTP can function as extracellular signaling molecules by activating plasma membrane receptors termed P2 purinergic receptors. In the present study a…”
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A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation by Lustig, K D, Kroll, K, Sun, E, Ramos, R, Elmendorf, H, Kirschner, M W

“…Using a paracrine assay to screen for signaling proteins that could respecify ectodermal tissue, we isolated a Xenopus gene related to the mouse gene nodal, a…”
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Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq by Lustig, K D, Conklin, B R, Herzmark, P, Taussig, R, Bourne, H R

“…Agonists for Gi-coupled receptors augment Gs-stimulated cAMP synthesis in human embryonic kidney (HEK) 293 cells transiently expressing the type II isozyme of…”
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Role of LXRs in control of lipogenesis by Schultz, J R, Tu, H, Luk, A, Repa, J J, Medina, J C, Li, L, Schwendner, S, Wang, S, Thoolen, M, Mangelsdorf, D J, Lustig, K D, Shan, B

“…The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and subsequent gene targeting studies in mice provided strong evidence that LXR…”
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A nucleotide receptor in vascular endothelial cells is specifically activated by the fully ionized forms of ATP and UTP by LUSTIG, K. D, SPORTIELLO, M. G, ERB, L, WEISMAN, G. A

“…Extracellular ATP causes an increase in the concentration of cytoplasmic free calcium ([Ca2+]i) in bovine pulmonary-artery endothelial (BPAE) cells that…”
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Growth inhibition of transformed mouse fibroblasts by adenine nucleotides occurs via generation of extracellular adenosine by Weisman, G A, Lustig, K D, Lane, E, Huang, N N, Belzer, I, Friedberg, I

“…The growth of transformed mouse fibroblasts (3T6 cells) in medium containing 5% fetal bovine serum was inhibited after treatment with concentrations greater…”
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Covalent incorporation of 3'-O-(4-benzoyl)benzoyl-ATP into a P2 purinoceptor in transformed mouse fibroblasts by ERB, L, LUSTIG, K. D, AHMED, A. H, GONZALEZ, F. A, WEISMAN, G. A

“…ATP, 3'-O-(4-benzoyl)benzoyl-ATP (BzATP), a photoaffinity analog of ATP, and several other ATP analogs induced an increase in plasma membrane permeability to…”
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Use of an Oocyte Expression Assay to Reconstitute Inductive Signaling by Lustig, K D, Kirschner, M W

“…We have developed a paracrine signaling assay capable of mimicking inductive events in the early vertebrate embryo. RNA encoding one or more secreted proteins…”
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Mechanisms by which extracellular ATP and UTP stimulate the release of prostacyclin from bovine pulmonary artery endothelial cells by Lustig, K D, Erb, L, Landis, D M, Hicks-Taylor, C S, Zhang, X, Sportiello, M G, Weisman, G A

“…Extracellular ATP and UTP caused increases in the concentration of cytoplasmic free calcium ([Ca2+]i) and the intracellular level of inositol…”
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Systematic identification of mitotic phosphoproteins by Stukenberg, P.Todd, Lustig, Kevin D., McGarry, Thomas J., King, Randall W., Kuang, Jian, Kirschner, Marc W.

“…Background: Cyclin-dependent kinases (CDKs) are thought to initiate and coordinate cell division processes by sequentially phosphorylating key targets; in most…”
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Extracellular ATP reversibly increases the plasma membrane permeability of transformed mouse fibroblasts to large macromolecules by Saribaş, A S, Lustig, K D, Zhang, X, Weisman, G A

“…Extracellular ATP increases the plasma membrane permeability of transformed mouse fibroblasts (3T6 cells) to fluorescein isothiocyanate-dextrans (4 and 9 kDa)…”
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Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy by Cryns, V L, Byun, Y, Rana, A, Mellor, H, Lustig, K D, Ghanem, L, Parker, P J, Kirschner, M W, Yuan, J

“…The caspase family of proteases plays a critical role in the execution of apoptosis. However, efforts to decipher the molecular mechanisms by which caspases…”
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Permeabilization of transformed mouse fibroblasts by 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate and the desensitization of the process by Gonzalez, F A, Ahmed, A H, Lustig, K D, Erb, L, Weisman, G A

“…A photoreactive analogue of ATP, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate (BzATP) altered the plasma membrane permeability of transformed 3T6 mouse…”
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Cloning of Mix-Related Homeodomain Proteins Using Fast Retrieval of Gel Shift Activities, (FROGS), a Technique for the Isolation of DNA-Binding Proteins by Mead, Paul E., Zhou, Yi, Lustig, Kevin D., Huber, Tara L., Kirschner, Marc W., Zon, Leonard I.

“…We have developed a technique, fast retrieval of gel shift activities (FROGS), that allows for the rapid isolation of proteins that interact with DNA. Using…”
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Detection of coincident signals by G proteins and adenylyl cyclase by Bourne, H R, Lustig, K D, Wong, Y H, Conklin, B R

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Expression Cloning in the Test Tube by King, Randall W., Lustig, Kevin D., Stukenberg, P. Todd, McGarry, Thomas J., Kirschner, Marc W.

“…A new cell-free expression cloning approach that substantially expands the range of biochemical assays that can be used to identify a cDNA on the basis of its…”
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Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development by Lustig, K D, Stukenberg, P T, McGarry, T J, King, R W, Cryns, V L, Mead, P E, Zon, L I, Yuan, J, Kirschner, M W

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