Search Results - "Lustgarten, S"

The Role of the Gut Microbiome on Skeletal Muscle Mass and Physical Function: 2019 Update by Lustgarten, Michael S

“…Within the past year, several studies have reported a positive role for the gut microbiome on the maintenance of skeletal muscle mass, evidence that contrasts…”
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Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis by Grosicki, Gregory J., Fielding, Roger A., Lustgarten, Michael S.

“…Skeletal muscle is a highly plastic tissue that plays a central role in human health and disease. Aging is associated with a decrease in muscle mass and…”
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A Phase 2 Trial of Ponatinib in Philadelphia Chromosome–Positive Leukemias by Cortes, J.E, Kim, D.-W, Pinilla-Ibarz, J, le Coutre, P, Paquette, R, Chuah, C, Nicolini, F.E, Apperley, J.F, Khoury, H.J, Talpaz, M, DiPersio, J, DeAngelo, D.J, Abruzzese, E, Rea, D, Baccarani, M, Müller, M.C, Gambacorti-Passerini, C, Wong, S, Lustgarten, S, Rivera, V.M, Clackson, T, Turner, C.D, Haluska, F.G, Guilhot, F, Deininger, M.W, Hochhaus, A, Hughes, T, Goldman, J.M, Shah, N.P, Kantarjian, H

“…Several tyrosine kinase inhibitors have activity in Ph-positive chronic and acute leukemia, but resistant disease and unacceptable side effects may limit…”
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The Kidney-Gut-Muscle Axis in End-Stage Renal Disease is Similarly Represented in Older Adults by Lustgarten, Michael S

“…Decreased renal function, elevated circulating levels of urea, intestinal levels of urea-degrading bacteria, and gut-derived uremic metabolites are present in…”
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Impact of a Whole-Food, High-Soluble Fiber Diet on the Gut-Muscle Axis in Aged Mice by Fielding, Roger A, Lustgarten, Michael S

“…Previous studies have identified a role for the gut microbiome and its metabolic products, short-chain fatty acids (SCFAs), in the maintenance of muscle mass…”
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Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial by Lipton, Jeffrey H, Prof, Chuah, Charles, MD, Guerci-Bresler, Agnès, MD, Rosti, Gianantonio, Prof, Simpson, David, Prof, Assouline, Sarit, MD, Etienne, Gabriel, MD, Nicolini, Franck E, MD, le Coutre, Philipp, Prof, Clark, Richard E, Prof, Stenke, Leif, MD, Andorsky, David, MD, Oehler, Vivian, MD, Lustgarten, Stephanie, PhD, Rivera, Victor M, PhD, Clackson, Timothy, PhD, Haluska, Frank G, MD, Baccarani, Michele, Prof, Cortes, Jorge E, Prof, Guilhot, François, Prof, Hochhaus, Andreas, Prof, Hughes, Timothy, Prof, Kantarjian, Hagop M, Prof, Shah, Neil P, Prof, Talpaz, Moshe, Prof, Deininger, Michael W, Prof

“…Summary Background Ponatinib has shown potent activity against chronic myeloid leukaemia that is resistant to available treatment, although it is associated…”
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Investigation of the Diet-Gut-Muscle Axis in the Osteoporotic Fractures in Men Study by Barger, K., Langsetmo, L., Orwoll, E. S., Lustgarten, Michael S.

“…Objectives To investigate the association between dietary fiber density (grams of fiber consumed per 100 kcal) with the gut-muscle axis in older adult men…”
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Branched Chain Amino Acids Are Associated With Muscle Mass in Functionally Limited Older Adults by Lustgarten, Michael S., Price, Lori Lyn, Chale, Angela, Phillips, Edward M., Fielding, Roger A.

“…Background. Metabolic profiling may provide insight into biologic mechanisms related to the maintenance of muscle and fat-free mass in functionally limited…”
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Serum Glycine Is Associated with Regional Body Fat and Insulin Resistance in Functionally-Limited Older Adults by Lustgarten, Michael S, Price, Lori Lyn, Phillips, Edward M, Fielding, Roger A, Hribal, Marta Letizia

“…Metabolic profiling may provide insight into biologic mechanisms related to age-related increases in regional adiposity and insulin resistance. The objectives…”
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High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates by Muller, Florian L, Liu, Yuhong, Abdul-Ghani, Muhammad A, Lustgarten, Michael S, Bhattacharya, Arunabh, Jang, Youngmok C, Van Remmen, Holly

“…Despite the considerable interest in superoxide as a potential cause of pathology, the mechanisms of its deleterious production by mitochondria remain poorly…”
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Metabolite signatures of chronological age, aging, survival, and longevity by Sebastiani, Paola, Monti, Stefano, Lustgarten, Michael S., Song, Zeyuan, Ellis, Dylan, Tian, Qu, Schwaiger-Haber, Michaela, Stancliffe, Ethan, Leshchyk, Anastasia, Short, Meghan I., Ardisson Korat, Andres V., Gurinovich, Anastasia, Karagiannis, Tanya, Li, Mengze, Lords, Hannah J., Xiang, Qingyan, Marron, Megan M., Bae, Harold, Feitosa, Mary F., Wojczynski, Mary K., O’Connell, Jeffrey R., Montasser, May E., Schupf, Nicole, Arbeev, Konstantin, Yashin, Anatoliy, Schork, Nicholas, Christensen, Kaare, Andersen, Stacy L., Ferrucci, Luigi, Rappaport, Noa, Perls, Thomas T., Patti, Gary J.

“…Metabolites that mark aging are not fully known. We analyze 408 plasma metabolites in Long Life Family Study participants to characterize markers of age,…”
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Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels by Lustgarten, Michael S., Bhattacharya, Arunabh, Muller, Florian L., Jang, Youngmok C., Shimizu, Takahiko, Shirasawa, Takuji, Richardson, Arlan, Van Remmen, Holly

“…► Complex I-generated, matrix-directed superoxide is released through VDACs. ► MnSOD-deficient mitochondria release more superoxide than wild type…”
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Dietary restriction attenuates age‐associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD by Jang, Young C., Liu, Yuhong, Hayworth, Christopher R., Bhattacharya, Arunabh, Lustgarten, Michael S., Muller, Florian L., Chaudhuri, Asish, Qi, Wenbo, Li, Yan, Huang, Jing‐Yi, Verdin, Eric, Richardson, Arlan, Van Remmen, Holly

“…Age‐related loss of muscle mass and function, sarcopenia, has a major impact on the quality of life in the elderly. Among the proposed causes of sarcopenia are…”
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Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice by Jang, Youngmok C., Pérez, Viviana I., Song, Wook, Lustgarten, Michael S., Salmon, Adam B., Mele, James, Qi, Wenbo, Liu, Yuhong, Liang, Hanyu, Chaudhuri, Asish, Ikeno, Yuji, Epstein, Charles J., Van Remmen, Holly, Richardson, Arlan

“…Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular…”
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Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials by Lustgarten, M. S., Fielding, Roger A.

“…It is estimated that in the next 20 years, the amount of people greater than 65 years of age will rise from 40 to 70 million, and will account for 19% of the…”
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Comparative efficacy of tyrosine kinase inhibitor treatments in the third-line setting, for chronic-phase chronic myelogenous leukemia after failure of second-generation tyrosine kinase inhibitors by Lipton, J.H, Bryden, P, Sidhu, M.K, Huang, H, McGarry, L.J, Lustgarten, S, Mealing, S, Woods, B, Whelan, J, Hawkins, N

“…Highlights • We compared the efficacy of ponatinib and 2G-TKIs in CP-CML after ≥1 prior 2G-TKI. • Relevant studies were identified by systematic review. •…”
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Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity by Lustgarten, Michael S, Jang, Youngmok C, Liu, Yuhong, Muller, Florian L, Qi, Wenbo, Steinhelper, Mark, Brooks, Susan V, Larkin, Lisa, Shimizu, Takahiko, Shirasawa, Takuji, McManus, Linda M, Bhattacharya, Arunabh, Richardson, Arlan, Van Remmen, Holly

“…In vitro studies of isolated skeletal muscle have shown that oxidative stress is limiting with respect to contractile function. Mitochondria are a potential…”
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Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults by Fielding, Roger A., Reeves, Andrew R., Jasuja, Ravi, Liu, Christine, Barrett, Brittany B., Lustgarten, Michael S.

“…Evidence in support of a gut-muscle axis has been reported in rodents, but studies in older adult humans are limited. Accordingly, the primary goals of the…”
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Duvelisib, an oral dual PI3K‐δ,γ inhibitor, efficacy and safety in patients with relapsed or refractory (RR) peripheral T‐cell lymphoma: rationale for the phase 2 PRIMO trial by Horwitz, S.M., Foss, F.M., Porcu, P., Moskowitz, A., Mehta‐Shah, N., Jacobsen, E., Khodadoust, M.S., Kim, Y.H., Weinstock, D., Lustgarten, S., Baglio, M., Youssoufian, H., Brammer, J.

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AN IMPROVED BENEFIT‐RISK PROFILE OF DUVELISIB IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA OR SMALL LYMPHOCYTIC LYMPHOMA WHO RECEIVED 2 OR MORE PRIOR THERAPIES by Flinn, I.W., Davids, M.S., Hillmen, P., Montillo, M., Delgado, J., Kuss, B.J., Tam, C.S., Jäger, U., Ghia, P., Stilgenbauer, S., Lustgarten, S., Weaver, D.T., Youssoufian, H., Cymbalista, F.

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