Search Results - "Lustgarten, Joseph"

Cancer, aging and immunotherapy: lessons learned from animal models by Lustgarten, Joseph

“…Aging of the immune system is associated with a dramatic reduction in responsiveness as well as functional dysregulation. This deterioration of immune function…”
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Fat tissue, aging, and cellular senescence by Tchkonia, Tamara, Morbeck, Dean E., Von Zglinicki, Thomas, Van Deursen, Jan, Lustgarten, Joseph, Scrable, Heidi, Khosla, Sundeep, Jensen, Michael D., Kirkland, James L.

“…Summary Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age‐related metabolic dysfunction. Fat…”
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High calories but not fat content of lard-based diet contribute to impaired mitochondrial oxidative phosphorylation in C57BL/6J mice heart by Emelyanova, Larisa, Boukatina, Anna, Myers, Cheryl, Oyarzo, Janice, Lustgarten, Joseph, Shi, Yang, Jahangir, Arshad

“…High calorie intake leads to obesity, a global socio-economic and health problem, reaching epidemic proportion in children and adolescents. Saturated and…”
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Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth by Manrique, Soraya Zorro, Correa, Maria Adelaida Duque, Hoelzinger, Dominique B, Dominguez, Ana Lucia, Mirza, Noweeda, Lin, Hsi-Hsien, Stein-Streilein, Joan, Gordon, Siamon, Lustgarten, Joseph

“…Regulatory T cells (T reg cells) are characterized by the expression of the forkhead lineage-specific transcription factor Foxp3, and their main function is to…”
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Flagellin Fusion Proteins as Adjuvants or Vaccines Induce Specific Immune Responses by Cuadros, Camilo, Lopez-Hernandez, Francisco J, Dominguez, Ana Lucia, McClelland, Michael, Lustgarten, Joseph

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Levels of Specific Peptide-HLA Class I Complex Predicts Tumor Cell Susceptibility to CTL Killing by Weidanz, Jon A, Nguyen, Tiffany, Woodburn, Tito, Neethling, Francisca A, Chiriva-Internati, Maurizio, Hildebrand, William H, Lustgarten, Joseph

“…Recognition of tumor-associated Ags (TAAs) on tumor cells by CTLs and the subsequent tumor cell death are assumed to be dependent on TAA protein expression and…”
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High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals by Sharma, Sanjay, Dominguez, Ana Lucia, Lustgarten, Joseph

“…In our previous in vivo study we demonstrated that young BALB/c mice effectively rejected the BM-185 tumor cells expressing enhanced GFP (EGFP) as a surrogate…”
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Targeting the tumor microenvironment with anti-neu/anti-CD40 conjugated nanoparticles for the induction of antitumor immune responses by Dominguez, Ana Lucia, Lustgarten, Joseph

“…Abstract Clinical and preclinical data indicate that immunotherapeutic interventions could induce immune responses capable of controlling or retard the tumor…”
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Maximal T Cell―Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells by GONZALEZ-MARTIN, Alicia, GOMEZ, Lucio, LUSTGARTEN, Joseph, MIRA, Emilia, MANES, Santos

“…Immune responses against cancer rely upon leukocyte trafficking patterns that are coordinated by chemokines. CCR5, the receptor for chemotactic chemokines…”
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Cancer immunotherapy: focusing on the young, neglecting the old by Lustgarten, Joseph

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Cancer, aging and immunotherapy: lessons learned from animal models : Imapct of aging on cancer immunity and immunotherapy by LUSTGARTEN, Joseph

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Implications of Aging and Self-Tolerance on the Generation of Immune and Antitumor Immune Responses by DOMINGUEZ, Ana Lucia, LUSTGARTEN, Joseph

“…Cancer statistics show a disproportionately higher burden of tumors in the old. Most of the studies evaluating vaccination strategies have not taken into…”
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Blockade of CCL1 inhibits T regulatory cell suppressive function enhancing tumor immunity without affecting T effector responses by Hoelzinger, Dominique B, Smith, Shannon E, Mirza, Noweeda, Dominguez, Ana Lucia, Manrique, Soraya Zorro, Lustgarten, Joseph

“…Intratumoral accumulation of T regulatory cells (Tregs) creates an immunosuppressive environment that reduces the efficacy of antitumor immunotherapy. The…”
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Comparative kinetic analyses of gene profiles of naïve CD4+ and CD8+ T cells from young and old animals reveal novel age‐related alterations by Mirza, Noweeda, Pollock, Kevin, Hoelzinger, Dominique B., Dominguez, Ana Lucia, Lustgarten, Joseph

“…Summary It is well established that immune responses are diminished in the old. However, we still do not have a clear understanding of what dictates the…”
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Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses by Smith, Shannon E., Hoelzinger, Dominique B., Dominguez, Ana Lucia, Van Snick, Jacques, Lustgarten, Joseph

“…Previous studies from our laboratory indicate that intratumoral (i.t.) injections of CpG-ODN are the most effective adjuvant strategy to induce an antitumor…”
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Critical function of CCL1 in the maintenance of T regulatory cell’s suppressive role. (66.14) by Hoelzinger, Dominique, Dominguez, Ana, Lustgarten, Joseph

“…Abstract T-regulatory cells (Tregs) create an immunosuppressive environment that reduces the efficacy of anti-tumor immunotherapy. Depletion of Tregs enhances…”
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B7-H1 expression on old CD8+ T cells negatively regulates the activation of immune responses in aged animals by Mirza, Noweeda, Duque, Maria Adelaida, Dominguez, Ana Lucia, Schrum, Adam G, Dong, Haidong, Lustgarten, Joseph

“…T cell responses are compromised in the elderly. The B7-CD28 family receptors are critical in the regulation of immune responses. We evaluated whether the…”
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Impact of aging on cancer immunity and immunotherapy by Pawelec, Graham, Lustgarten, Joseph, Ruby, Carl, Gravekamp, Claudia

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IL-9 strategy to perturb Treg function and enhance anti-tumor immunity (P4273) by Hoelzinger, Dominique, Dominguez, Ana, Pollock, Kevin, Lustgarten, Joseph, Cohen, Peter, Gendler, Sandra

“…Abstract IL-9 is a cytokine that is primarily associated with mast cells and airway inflammation, however it also plays a role in T regulatory cell (Treg)…”
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Systemic Targeting of CpG-ODN to the Tumor Microenvironment with Anti-neu-CpG Hybrid Molecule and T Regulatory Cell Depletion Induces Memory Responses in BALB-neuT Tolerant Mice by SHARMA, Sanjay, DOMINGUEZ, Ana Lucia, ZORRO MANRIQUE, Soraya, CAVALLO, Federica, SAKAGUCHI, Shimon, LUSTGARTEN, Joseph

“…We have shown that neu transgenic mice are immunotolerant and that immunizations with dendritic cells (DC) pulsed with neu-derived antigens were not able to…”
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