Search Results - "Lust, W. David"

Neuroprotection in diet-induced ketotic rat brain after focal ischemia by Puchowicz, Michelle A, Zechel, Jennifer L, Valerio, Jose, Emancipator, Douglas S, Xu, Kui, Pundik, Svetlana, LaManna, Joseph C, Lust, W David

“…Neuroprotective properties of ketosis may be related to the upregulation of hypoxia inducible factor (HIF)-1α, a primary constituent associated with hypoxic…”
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Activation of caspase-12, an endoplasmic reticulum resident caspase, after permanent focal ischemia in rat by Mouw, Graham, Zechel, Jennifer L, Gamboa, Jorge, Lust, W David, Selman, Warren R, Ratcheson, Robert A

“…The endoplasmic reticulum (ER) is emerging as a contributory component of cell death after ischemia. Since caspase-12 has been localized to the ER and is a…”
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Comparison of Glucose Influx and Blood Flow in Retina and Brain of Diabetic Rats by Puchowicz, Michelle A., Xu, Kui, Magness, Danielle, Miller, Casey, Lust, W. David, Kern, Timothy S., LaManna, Joseph C.

“…Diabetes is associated with extensive microvascular pathology and decreased expression of the glucose transporter (GLUT-1) in retina, but not brain. To explore…”
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Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia by Zechel, Jennifer L., Gamboa, Jorge L., Peterson, Allyn G., Puchowicz, Michelle A., Selman, Warren R., Lust, W. David

“…BACKGROUND: Neonatal neurodevelopment is influenced by a variety of external factors, although the mechanisms responsible are poorly understood. Prenatal…”
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Regional metabolic status of the E-18 rat fetal brain following transient hypoxia/ischemia by PUNDIK, Svetlana, ROBINSON, Shenandoah, LUST, W. David, ZECHEL, Jennifer, BUCZEK, Marek, SELMAN, Warren R

“…Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study…”
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Compromised metabolic recovery following spontaneous spreading depression in the penumbra by Selman, Warren R., Lust, W.David, Pundik, Svetlana, Zhou, Yinong, Ratcheson, Robert A.

“…Spreading depression (SD) has been demonstrated following focal ischemia, and the additional workload imposed by SD on a tissue already compromised by a marked…”
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Biochemical methods to assess the coupling of brain energy metabolism in control and disease states by Zechel, Jennifer, Lust, W David, Puchowicz, Michele

“…Mitochondrial dysfunction has been increasingly shown as a critical process that makes certain areas of the brain more susceptible not only to neurological…”
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Adenosine treatment delays postischemic hippocampal CA1 loss after cardiac arrest and resuscitation in rats by Xu, Kui, Puchowicz, Michelle A., Lust, W. David, LaManna, Joseph C.

“…Resuscitation from cardiac arrest results in reperfusion injury that leads to increased postresuscitation mortality and delayed neuronal death. One of the many…”
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A new model of oxidative stress in rat pups by Gelfand, Steven L, Vento, Maximo, Sastre, Juan, Lust, W David, Smith, Mark A, Perry, George, Walsh, Michele, Martin, Richard

“…With current evidence, no specific oxygen concentration can yet be recommended in the resuscitation of the depressed term neonate. To design a neonatal rat…”
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Changing metabolic and energy profiles in fetal, neonatal, and adult rat brain by LUST, W. David, PUNDIK, Svetlana, ZECHEL, Jennifer, YINONG ZHOU, BUCZEK, Marek, SELMAN, Warren R

“…The regional energy status and the availability of metabolic substrates during brain development are important, since a variety of fetal metabolic insults have…”
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Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat by George III, John E., Ahmad, Yusra, Varghai, Davood, Li, Xiaolin, Berlin, Jeffrey, Jackowe, David, Jungermann, Marc, Wolfe, Michael S., Lilge, Lothar, Totonchi, Ali, Morris, Rachel L., Peterson, Allyn, Lust, W. David, Kenney, Malcolm E., Hoppel, Charles L., Sun, Jiayang, Oleinick, Nancy L., Dean, David

“…Background and Objectives As a potential therapy for malignant glioma, we tested the phthalocyanine photosensitizer Pc 4 for: (1) rapid clearance from the…”
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Adaptation to chronic hypoxia during diet-induced ketosis by Puchowicz, Michelle A, Emancipator, Douglas S, Xu, Kui, Magness, Danielle L, Ndubuizu, Obinna I, Lust, W David, LaManna, Joseph C

“…It is recognized that brain oxygen deprivation results in increased glycolysis and lactate accumulation. Moreover, glucose metabolism is altered during…”
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Caspase-9 inhibition after focal cerebral ischemia improves outcome following reversible focal ischemia by MOUW, Graham, ZECHEL, Jennifer L, YIFANG ZHOU, LUST, W. David, SELMAN, Warren R, RATCHESON, Robert A

“…Cerebral ischemia initiates a program of cell death known as apoptosis. Early steps in these death promoting events are the release of cytochrome c from the…”
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Substrates of Energy Metabolism Attenuate Methamphetamine‐Induced Neurotoxicity in Striatum by Stephans, Stacy E., Whittingham, Tim S., Douglas, Albertina J., Lust, W. David, Yamamoto, Bryan K.

“…: High doses of methamphetamine (METH) produce a long‐term depletion in striatal tissue dopamine content. The mechanism mediating this toxicity has been…”
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Alterations in matrix metalloproteinase-9 levels and tissue inhibitor of matrix metalloproteinases-1 expression in a transforming growth factor-β transgenic model of hydrocephalus by Zechel, Jennifer, Gohil, Harsh, Lust, W. David, Cohen, Alan

“…The development of spontaneous hydrocephalus in mouse models resulting from the overexpression of transforming growth factor‐β (TGFβ‐1) has been previously…”
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Ischemic cell death: Dynamics of delayed secondary energy failure during reperfusion following focal Ischemia by LUST, W. David, TAYLOR, Christopher, PUNDIK, Svetlana, SELMAN, Warren R, RATCHESON, Robert A

“…Reperfusion injury is believed to contribute to the pathophysiology of ischemic cell death, but the precipitating factors have yet to be completely elucidated…”
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Diet-induced ketosis does not cause cerebral acidosis by Al-Mudallal, A S, LaManna, J C, Lust, W D, Harik, S I

“…Ketosis is beneficial for seizure control, possibly through induction of cerebral acidosis. However, cerebral intracellular pH has not previously been measured…”
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Delayed changes in regional brain energy metabolism following cerebral concussion in rats by BUCZEK, Marek, ALVAREZ, Jamie, AZHAR, Jaffar, YINONG ZHOU, LUST, W. David, SELMAN, Warren R, RATCHESON, Robert A

“…Traumatic brain injury (TBI) results in an acute altered metabolic profile of brain tissue which resolves within hours of initial insult and yet some of the…”
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Characterization of a model of hydrocephalus in transgenic mice by COHEN, A. R, LEIFER, D. W, ZECHEL, M, FLANINGAN, D. P, LEWIN, J. S, LUST, W. D

“…The purpose of this study was to elucidate the pathophysiological characteristics of hydrocephalus in a new transgenic model of mice created to overproduce the…”
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Effects of unbalanced diets on cerebral glucose metabolism in the adult rat by Al-Mudallal, Ali S, Levin, Barry E, Lust, W David, Harik, Sami I

“…We measured regional cerebral metabolic rates for glucose and selected cerebral metabolites in rats fed one of the following diets for 6 to 7 weeks:(1) regular…”
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