Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia

Hemoglobin levels correlate with interleukin-6 levels in patients with advanced untreated epithelial ovarian cancer: role of inflammation in cancer-related anemia

Anemia occurs in more than 30% of patients with epithelial ovarian cancer before any surgery. High levels of proinflammatory cytokines and increased oxidative stress may contribute to the development of cancer-related anemia. We assessed a population of previously untreated patients with advanced ep...

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Bibliographic Details
Published in:Blood Vol. 106; no. 1; pp. 362 - 367
Main Authors: Macciò, Antonio, Madeddu, Clelia, Massa, Daniela, Mudu, Maria C., Lusso, Maria R., Gramignano, Giulia, Serpe, Roberto, Melis, Gian Benedetto, Mantovani, Giovanni
Format: Journal Article
Language:English
Published: Washington, DC Elsevier Inc 01-07-2005
The Americain Society of Hematology
Subjects:
Aged
Aged, 80 and over
Anemia - blood
Anemia - etiology
Anemia - immunology
Anemias. Hemoglobinopathies
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - metabolism
Diseases of red blood cells
Epithelial Cells
Erythrocyte Count
Female
Female genital diseases
Ferritins - blood
Fibrinogen - metabolism
Glutathione Peroxidase - blood
Gynecology. Andrology. Obstetrics
Hematologic and hematopoietic diseases
Hemoglobins
Humans
Interleukin-1 - blood
Interleukin-6 - blood
Iron - blood
Leptin - blood
Medical sciences
Middle Aged
Ovarian Neoplasms - blood
Ovarian Neoplasms - complications
Ovarian Neoplasms - immunology
Reactive Oxygen Species - blood
Reticulocyte Count
Superoxide Dismutase - blood
Tumor Necrosis Factor-alpha - metabolism
Tumors
Human
Oxidative stress
Ovary carcinoma
Anemia
Cytokine
Hemopathy
Inflammation
Malignant tumor
Female genital diseases
Interleukin 6
Ovarian diseases
Hemoglobin
Advanced stage
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Summary:Anemia occurs in more than 30% of patients with epithelial ovarian cancer before any surgery. High levels of proinflammatory cytokines and increased oxidative stress may contribute to the development of cancer-related anemia. We assessed a population of previously untreated patients with advanced epithelial ovarian cancer to evaluate whether there was a correlation between hemoglobin (Hb) and parameters of inflammation and oxidative stress, stage of disease, and performance status (PS). In 91 patients with epithelial ovarian cancer and 95 healthy women matched for age, weight, and height, levels of Hb, C-reactive protein (CRP), fibrinogen (Fbg), proinflammatory cytokines, leptin, reactive oxygen species (ROS), and antioxidant enzymes were assessed at diagnosis before treatment. The correlations between Hb, parameters of inflammation and oxidative stress, stage, and PS were evaluated. Hb levels were lower in patients with advanced epithelial ovarian cancer than in control subjects and inversely related to stage and PS. Hb negatively correlated with CRP, Fbg, interleukin 1β (IL-1β), IL-6, tumor necrosis factor α (TNFα), and ROS, and positively correlated with leptin and glutathione peroxidase (GPx). Multivariate regression analysis showed that stage and IL-6 were independent factors determining Hb values. This evidence suggests that anemia in epithelial ovarian cancer is common and its presence is related to stage of disease and markers of inflammation.
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ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2005-01-0160