Search Results - "Lussier, Marc P."

Overview of Sigma-1R Subcellular Specific Biological Functions and Role in Neuroprotection by Lachance, Véronik, Bélanger, Sara-Maude, Hay, Célia, Le Corvec, Victoria, Banouvong, Vina, Lapalme, Mathieu, Tarmoun, Khadija, Beaucaire, Guillaume, Lussier, Marc P, Kourrich, Saïd

“…For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through…”
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GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons by Gu, Xinglong, Mao, Xia, Lussier, Marc P., Hutchison, Mary Anne, Zhou, Liang, Hamra, F. Kent, Roche, Katherine W., Lu, Wei

“…Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism for synaptic plasticity. In the brain, AMPARs assemble with a number of…”
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Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167 by Ghilarducci, Kim, Cabana, Valérie C., Harake, Ali, Cappadocia, Laurent, Lussier, Marc P.

“…Rab7 is a GTPase that controls late endosome and lysosome trafficking. Recent studies have demonstrated that Rab7 is ubiquitinated, a post-translational…”
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Activity-dependent ubiquitination of the AMPA receptor subunit GluA2 by Lussier, Marc P, Nasu-Nishimura, Yukiko, Roche, Katherine W

“…AMPA receptors (AMPARs) are postsynaptic glutamate-gated ion channels that mediate fast excitatory neurotransmission in the mammalian brain. Synaptic activity…”
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Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission by Lussier, Marc P, Herring, Bruce E, Nasu-Nishimura, Yukiko, Neutzner, Albert, Karbowski, Mariusz, Youle, Richard J, Nicoll, Roger A, Roche, Katherine W

“…AMPA receptors (AMPARs) mediate the majority of fast excitatory neurotransmission, and their density at postsynaptic sites determines synaptic strength…”
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From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease by Cabana, Valérie C, Lussier, Marc P

“…The ubiquitin-proteasome system is of fundamental importance in all fields of biology due to its impact on proteostasis and in regulating cellular processes…”
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RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association by Cabana, Valérie C, Bouchard, Antoine Y, Sénécal, Audrey M, Ghilarducci, Kim, Kourrich, Saïd, Cappadocia, Laurent, Lussier, Marc P

“…Developmental and epileptic encephalopathies (DEE) are rare and serious neurological disorders characterized by severe epilepsy with refractory seizures and a…”
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Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications by Lussier, Marc P., Sanz-Clemente, Antonio, Roche, Katherine W.

“…Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of…”
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Identification of Two Domains Involved in the Assembly of Transient Receptor Potential Canonical Channels by Lepage, Pascale K., Lussier, Marc P., Barajas-Martinez, Hector, Bousquet, Simon M., Blanchard, Alexandre P., Francoeur, Nancy, Dumaine, Robert, Boulay, Guylain

“…Transient receptor potential canonical (TRPC) channels are associated with calcium entry activity in nonexcitable cells. TRPCs can form homo- or…”
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Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice by Ve, Hou, Cabana, Valérie C., Gouspillou, Gilles, Lussier, Marc P.

“…•Abundance of neuronal proteins, such as AMPA receptors, is not altered by normal aging.•Aged mouse brains show reduced abundance of actin and synaptophysin…”
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AP-1 contributes to endosomal targeting of the ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif by Cabana, Valérie C, Sénécal, Audrey M, Bouchard, Antoine Y, Kourrich, Saïd, Cappadocia, Laurent, Lussier, Marc P

“…Cellular trafficking between organelles is typically assured by short motifs that contact carrier proteins to transport them to their destination. The…”
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Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor by Ghilarducci, Kim, Cabana, Valérie C., Desroches, Camille, Chabi, Kahina, Bourgault, Steve, Cappadocia, Laurent, Lussier, Marc P.

“…Protein ubiquitination has been historically associated with protein degradation, but recent studies have demonstrated other cellular functions associated with…”
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RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC by Lussier, Marc P, Lepage, Pascale K, Bousquet, Simon M, Boulay, Guylain

“…Abstract TRPCs function as cation channels in non-excitable cells. The N-terminal tails of all TRPCs contain an ankyrin-like repeat domain, one of the most…”
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MxA, a Member of the Dynamin Superfamily, Interacts with the Ankyrin-like Repeat Domain of TRPC by Lussier, Marc P., Cayouette, Sylvie, Lepage, Pascale K., Bernier, Cynthia L., Francoeur, Nancy, St-Hilaire, Marie, Pinard, Maxime, Boulay, Guylain

“…Mammalian transient receptor potential canonical channels have been proposed as the molecular entities associated with calcium entry activity in nonexcitable…”
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Casein kinase 2 phosphorylates GluA1 and regulates its surface expression by Lussier, Marc P., Gu, Xinglong, Lu, Wei, Roche, Katherine W.

“…Controlling the density of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors (AMPARs) at synapses is essential for regulating the strength of…”
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Identification of a conformational heparin-recognition motif on the peptide hormone secretin: key role for cell surface binding by Quittot, Noé, Nguyen, Phuong Trang, Nerée, Armelle Tchoumi, Lussier, Marc P, Bourgault, Steve

“…Secretin is a peptide hormone that exerts pleiotropic physiological functions by specifically binding to its cognate membrane-bound receptor. The membrane…”
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Exocytotic Insertion of TRPC6 Channel into the Plasma Membrane upon Gq Protein-coupled Receptor Activation by Cayouette, Sylvie, Lussier, Marc P., Mathieu, Eve-Lyne, Bousquet, Simon M., Boulay, Guylain

“…TRPC proteins are the mammalian homologues of the Drosophila transient receptor potential channel and are involved in calcium entry after agonist stimulation…”
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The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells by Lessard, Christian B, Lussier, Marc P, Cayouette, Sylvie, Bourque, Geneviève, Boulay, Guylain

“…Mutations in the presenilin (PS) genes are linked to the development of early-onset Alzheimer's disease by a gain-of-function mechanism that alters proteolytic…”
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TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling by Mace, Kimberly E., Lussier, Marc P., Boulay, Guylain, Terry-Powers, Jennifer L., Parfrey, Helen, Perraud, Anne-Laure, Riches, David W.H.

“…Although most signaling responses initiated by tumor necrosis factor‐α (TNF‐α) occur in a Ca2+‐independent fashion, TNF‐α receptor signaling augments Ca2+…”
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The self-association of two N-terminal interaction domains plays an important role in the tetramerization of TRPC4 by Lepage, Pascale K, Lussier, Marc P, McDuff, François-Olivier, Lavigne, Pierre, Boulay, Guylain

“…Abstract Transient receptor potential canonical (TRPC) channels function as cation channels. In a previous study, we identified the molecular determinants…”
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