Search Results - "Lusis, A. J"

Hepatocellular carcinoma in Txnip-deficient mice by SHETH, S. S, BODNAR, J. S, GHAZALPOUR, A, THIPPHAVONG, C. K, TSUTSUMI, S, TWARD, A. D, DEMANT, P, KODAMA, T, ABURATANI, H, LUSIS, A. J

“…The molecular pathogenesis and the genetic aberrations that lead to the progression of hepatocellular carcinoma (HCC) are largely unknown. Here, we demonstrate…”
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A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci by Gale, G D, Yazdi, R D, Khan, A H, Lusis, A J, Davis, R C, Smith, D J

“…Understanding the genetics of behavioral variation remains a fascinating but difficult problem with considerable theoretical and practical implications. We…”
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Identification of ALOX5 as a gene regulating adiposity and pancreatic function by Mehrabian, M, Schulthess, F. T, Nebohacova, M, Castellani, L. W, Zhou, Z, Hartiala, J, Oberholzer, J, Lusis, A. J, Maedler, K, Allayee, H

“…Aims/hypothesis We previously used an integrative genetics approach to demonstrate that 5-lipoxygenase (5-LO) deficiency in mice (Alox5 ⁻/⁻) protects against…”
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Heparin-binding EGF-like growth factor (HB-EGF) antisense oligonucleotide protected against hyperlipidemia-associated atherosclerosis by Kim, S., Graham, M.J., Lee, R.G., Yang, L., Subramanian, V., Layne, J.D., Cai, L., Temel, R.E., Shih, D., Lusis, A.J., Berliner, J.A., Lee, S.

“…Heparin-binding EGF-like growth factor (HB-EGF) is a representative EGF family member that interacts with EGFR under diverse stress environment. Previously, we…”
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Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis by Lusis, Aldons J, Shih, Diana M, Gu, Lingjie, Xia, Yu-Rong, Navab, Mohamad, Li, Wan-Fen, Hama, Susan, Castellani, Lawrence W, Furlong, Clement E, Costa, Lucio G, Fogelman, Alan M

“…Serum paraoxonase (PON1) is an esterase that is associated with high-density lipoproteins (HDLs) in the plasma; it is involved in the detoxification of…”
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Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice by Qiao, JH, Tripathi, J, Mishra, NK, Cai, Y, Tripathi, S, Wang, XP, Imes, S, Fishbein, MC, Clinton, SK, Libby, P, Lusis, AJ, Rajavashisth, TB

“…Previous in vitro and in vivo studies have suggested that macrophage colony-stimulating factor (M-CSF) plays a role in atherogenesis. To examine this…”
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Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N‐oxide‐generating pathway, modulates platelet responsiveness and thrombosis risk by Zhu, W., Buffa, J. A., Wang, Z., Warrier, M., Schugar, R., Shih, D. M., Gupta, N., Gregory, J. C., Org, E., Fu, X., Li, L., DiDonato, J. A., Lusis, A. J., Brown, J. M., Hazen, S. L.

“…Essentials Microbe‐dependent production of trimethylamine N‐oxide (TMAO) contributes to thrombosis risk. The impact of host flavin monooxygenase 3 (FMO3)…”
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Increased atherosclerosis in myeloperoxidase-deficient mice by Brennan, M L, Anderson, M M, Shih, D M, Qu, X D, Wang, X, Mehta, A C, Lim, L L, Shi, W, Hazen, S L, Jacob, J S, Crowley, J R, Heinecke, J W, Lusis, A J

“…Myeloperoxidase (MPO), a heme enzyme secreted by activated phagocytes, generates an array of oxidants proposed to play critical roles in host defense and local…”
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Atherosclerosis : basic mechanisms : oxidation, inflammation, and genetics by BERLINER, J. A, MOHAMAD NAVAB, FOGELMAN, A. M, FRANK, J. S, DEMER, L. L, EDWARDS, P. A, WATSON, A. D, LUSIS, A. J

“…The clinical events resulting from atherosclerosis are directly related to the oxidation of lipids in LDLs that become trapped in the extracellular matrix of…”
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Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes by León-Mimila, P., Villamil-Ramírez, H., Li, X.S., Shih, D.M., Hui, S.T., Ocampo-Medina, E., López-Contreras, B., Morán-Ramos, S., Olivares-Arevalo, M., Grandini-Rosales, P., Macías-Kauffer, L., González-González, I., Hernández-Pando, R., Gómez-Pérez, F., Campos-Pérez, F., Aguilar-Salinas, C., Larrieta-Carrasco, E., Villarreal-Molina, T., Wang, Z., Lusis, A.J., Hazen, S.L., Huertas-Vazquez, A., Canizales-Quinteros, S.

“…Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic…”
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Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL by Ishikawa, K, Navab, M, Leitinger, N, Fogelman, A M, Lusis, A J

“…Heme catabolic processes produce the antioxidants biliverdin and bilirubin, as well as the potent prooxidant free iron. Since these products have opposing…”
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Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins by Rajavashisth, T. B, Andalibi, A, Territo, M. C, Berliner, J. A, Navab, M, Fogelman, A. M, Lusis, A. J

“…Oxidized lipoproteins have been identified in atherosclerotic plaques and in early lesions in humans as well as in animals. There is accumulating evidence that…”
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Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice by WEIBIN SHI, HABERLAND, M. E, JIEN, M.-L, SHIH, D. M, LUSIS, A. J

“…Oxidized LDL has been found within the subendothelial space, and it exhibits numerous atherogenic properties, including induction of inflammatory genes. We…”
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Genetic control of inflammatory gene induction and NF-κB-like transcription factor activation in response to an atherogenic diet in mice by FENG LIAO, ALI ANDALIBI, DEBEER, F. C, FOGELMAN, A. M, LUSIS, A. J

“…A high fat, high cholesterol "atherogenic" diet induced considerably greater hepatic levels of conjugated dienes and expression of several inflammatory and…”
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The Yin and Yang of Oxidation in the Development of the Fatty Streak: A Review Based on the 1994 George Lyman Duff Memorial Lecture by Navab, Mohamad, Berliner, Judith A, Watson, Andrew D, Hama, Susan Y, Territo, Mary C, Lusis, Aldons J, Shih, Diana M, Van Lenten, Brian J, Frank, Joy S, Demer, Linda L, Edwards, Peter A, Fogelman, Alan M

“…Recent data support the hypothesis that the fatty streak develops in response to specific phospholipids contained in LDL that become trapped in the artery wall…”
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Pathology of atheromatous lesions in inbred and genetically engineered mice : genetic determination of arterial calcification by JIAN-HUA QIAO, PEI-ZHEN XIE, FISHBEIN, M. C, KREUZER, J, DRAKE, T. A, DEMER, L. L, LUSIS, A. J

“…We report comprehensive pathological studies of atheromatous lesions in various inbred mouse strains fed a high-fat, high-cholesterol diet and in two…”
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Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio by Navab, M, Hama-Levy, S, Van Lenten, B J, Fonarow, G C, Cardinez, C J, Castellani, L W, Brennan, M L, Lusis, A J, Fogelman, A M, La Du, B N

“…We have examined the effects of mildly oxidized LDL and atherosclerosis on the levels of two proteins associated with HDL; apolipoprotein J (apoJ), and…”
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Atherosclerosis by Lusis, Aldons J

“…Atherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. In westernized societies, it is the underlying cause of…”
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Determinants of Atherosclerosis Susceptibility in the C3H and C57BL/6 Mouse Model: Evidence for Involvement of Endothelial Cells but Not Blood Cells or Cholesterol Metabolism by Shi, Weibin, Wang, Nicholas J, Shih, Diana M, Sun, Victor Z, Wang, Xuping, Lusis, Aldons J

“…Lipids, monocytes, and arterial wall cells are primary components involved in atherogenesis. Using the inbred mouse strains C57BL/6J (B6) and C3H/HeJ (C3H),…”
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Mapping a gene for combined hyperlipidaemia in a mutant mouse strain by Castellani, Lawrence W, Weinreb, Ari, Bodnar, Jackie, Goto, Aimie M, Doolittle, Mark, Mehrabian, Margarete, Demant, Peter, Lusis, Aldons J

“…Familial combined hyperlipidaemia (FCHL) is a common, multifactorial disorder associated with elevated levels of plasma triglyceride, cholesterol, or both. A…”
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