Search Results - "Luscher, Bernhard"

GABAA receptor trafficking-mediated plasticity of inhibitory synapses by Luscher, Bernhard, Fuchs, Thomas, Kilpatrick, Casey L

“…Proper developmental, neural cell-type-specific, and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS…”
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The CCNY (cyclin Y)-CDK16 kinase complex: a new regulator of autophagy downstream of AMPK by Vervoorts, Jörg, Neumann, Dietbert, Lüscher, Bernhard

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ADP‐ribosyltransferases, an update on function and nomenclature by Lüscher, Bernhard, Ahel, Ivan, Altmeyer, Matthias, Ashworth, Alan, Bai, Peter, Chang, Paul, Cohen, Michael, Corda, Daniela, Dantzer, Françoise, Daugherty, Matthew D., Dawson, Ted M., Dawson, Valina L., Deindl, Sebastian, Fehr, Anthony R., Feijs, Karla L. H., Filippov, Dmitri V., Gagné, Jean‐Philippe, Grimaldi, Giovanna, Guettler, Sebastian, Hoch, Nicolas C., Hottiger, Michael O., Korn, Patricia, Kraus, W. Lee, Ladurner, Andreas, Lehtiö, Lari, Leung, Anthony K. L., Lord, Christopher J., Mangerich, Aswin, Matic, Ivan, Matthews, Jason, Moldovan, George‐Lucian, Moss, Joel, Natoli, Gioacchino, Nielsen, Michael L., Niepel, Mario, Nolte, Friedrich, Pascal, John, Paschal, Bryce M., Pawłowski, Krzysztof, Poirier, Guy G., Smith, Susan, Timinszky, Gyula, Wang, Zhao‐Qi, Yélamos, José, Yu, Xiaochun, Zaja, Roko, Ziegler, Mathias

“…ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for…”
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Intracellular Mono-ADP-Ribosylation in Signaling and Disease by Bütepage, Mareike, Eckei, Laura, Verheugd, Patricia, Lüscher, Bernhard

“…A key process in the regulation of protein activities and thus cellular signaling pathways is the modification of proteins by post-translational mechanisms…”
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Full function of exon junction complex factor, Rbm8a, is critical for interneuron development by McSweeney, Colleen, Dong, Fengping, Chen, Miranda, Vitale, Jessica, Xu, Li, Crowley, Nicole, Luscher, Bernhard, Zou, Donghua, Mao, Yingwei

“…The formation of the nervous system requires a balance between proliferation, differentiation, and migration of neural progenitors (NPs). Mutations in genes…”
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Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation by Hydbring, Per, Bahram, Fuad, Su, Yingtao, Tronnersjö, Susanna, Högstrand, Kari, von der Lehr, Natalie, Sharifi, Hamid Reza, Lilischkis, Richard, Hein, Nadine, Wu, Siqin, Vervoorts, Jörg, Henriksson, Marie, Grandien, Alf, Lüscher, Bernhard, Larsson, Lars-Gunnar

“…The MYC and RAS oncogenes are frequently activated in cancer and, together, are sufficient to transform rodent cells. The basis for this cooperativity remains…”
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GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice by Shen, Qiuying, Fuchs, Thomas, Sahir, Nadia, Luscher, Bernhard

“…Vulnerability for anxiety and depressive disorders is thought to have origins in early life and is increasingly recognized to involve deficits in GABAergic…”
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GODZ-Mediated Palmitoylation of GABAA Receptors Is Required for Normal Assembly and Function of GABAergic Inhibitory Synapses by Fang, Cheng, Deng, Lunbin, Keller, Cheryl A, Fukata, Masaki, Fukata, Yuko, Chen, Gong, Luscher, Bernhard

“…Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ) is a DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated…”
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GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses by Fang, Cheng, Deng, Lunbin, Keller, Cheryl A, Fukata, Masaki, Fukata, Yuko, Chen, Gong, Lüscher, Bernhard

“…Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ) is a DHHC family palmitoyl acyltransferase that is implicated in palmitoylation and regulated…”
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Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors by Venkannagari, Harikanth, Fallarero, Adyary, Feijs, Karla L.H., Lüscher, Bernhard, Lehtiö, Lari

“…Poly(ADP-ribose) polymerases (PARPs) or diphtheria toxin like ADP-ribosyl transferases (ARTDs) are enzymes that catalyze the covalent modification of proteins…”
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Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant by Li, Jinyu, Vervoorts, Jorg, Carloni, Paolo, Rossetti, Giulia, Luscher, Bernhard

“…The cyclin-dependent kinase 2 (CDK2) together with its cyclin E and A partners is a central regulator of cell growth and division. Deregulation of CDK2…”
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The GDP-GTP Exchange Factor Collybistin: An Essential Determinant of Neuronal Gephyrin Clustering by Harvey, Kirsten, Duguid, Ian C, Alldred, Melissa J, Beatty, Sarah E, Ward, Hamish, Keep, Nicholas H, Lingenfelter, Sue E, Pearce, Brian R, Lundgren, Johan, Owen, Michael J, Smart, Trevor G, Luscher, Bernhard, Rees, Mark I, Harvey, Robert J

“…Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is…”
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Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice by Jefferson, Sarah J., Feng, Mengyang, Chon, URee, Guo, Yao, Kim, Yongsoo, Luscher, Bernhard

“…Chronic stress represents a vulnerability factor for anxiety and depressive disorders and has been widely used to model aspects of these disorders in rodents…”
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Proteins of the Myc network: essential regulators of cell growth and differentiation by Henriksson, M, Lüscher, B

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PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation by MEI YU, SCHREEK, Sabine, MEHRAEIN, Yasmin, MERTSCHING, Jürgen, KRAFT, Regine, AUSTEN, Matthias, LÜSCHER-FIRZLAFF, Juliane, LÜSCHER, Bernhard, CERNI, Christa, SCHAMBERGER, Chantal, LESNIEWICZ, Krzysztof, POREBA, Elzbieta, VERVOORTS, Jörg, WALSEMANN, Gesa, GRÖTZINGER, Joachim, KREMMER, Elisabeth

“…The proto-oncoprotein c-Myc functions as a transcriptional regulator that controls different aspects of cell behavior, including proliferation,…”
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In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties by Malyshev, Anton V, Sukhanova, Iuliia A, Zlobin, Alexander S, Gedzun, Vasilina R, Pavshintsev, Vsevolod V, Vasileva, Ekaterina V, Zalevsky, Arthur O, Doronin, Igor I, Mitkin, Nikita A, Golovin, Andrey V, Lovat, Maxim L, Kovalev, Georgy I, Zolotarev, Yurii A, Kuchumov, Askar R, Babkin, Gennady A, Luscher, Bernhard

“…The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABA receptors and the α2δ auxiliary subunit of V-gated Ca channels…”
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SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system by Arnaud, Estelle, Zenker, Jennifer, de Preux Charles, Anne-Sophie, Stendel, Claudia, Roos, Andreas, Médard, Jean-Jacques, Tricaud, Nicolas, Weis, Joachim, Suter, Ueli, Senderek, Jan, Chrast, Roman

“…Charcot-Marie-Tooth disease type 4C (CMT4C) is an early-onset, autosomal recessive form of demyelinating neuropathy. The clinical manifestations include…”
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Gamma-Aminobutyric Acidergic Deficits Cause Melancholic Depression: A Reply to Markou and Geyer by Luscher, Bernhard, Shen, Qiuying

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GABAergic Terminals Are Required for Postsynaptic Clustering of Dystrophin But Not of GABAA Receptors and Gephyrin by Brunig, Ina, Suter, Anthi, Knuesel, Irene, Luscher, Bernhard, Fritschy, Jean-Marc

“…In rat hippocampal cultures, we show by multilabeling immunocytochemistry that pyramidal cells, which receive little or no GABAergic input, mistarget α 2 -GABA…”
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Regulation of the transcription factor FOXM1c by Cyclin E/CDK2 by Lüscher-Firzlaff, Juliane M., Lilischkis, Richard, Lüscher, Bernhard

“…The FOXM1 forkhead proteins, originally identified as M-phase phosphoproteins, are proliferation-associated transcriptional regulators involved in cell cycle…”
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