Search Results - "Luraghi, Andrea"
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Selective SERCA2a activator as a candidate for chronic heart failure therapy
Published in Journal of translational medicine (19-01-2024)“…The sarcoplasmic reticulum (SR) Ca ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that…”
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Electrospinning for drug delivery applications: A review
Published in Journal of controlled release (10-06-2021)“…Drug delivery devices are promising tools in the pharmaceutical field, as they are able to maximize the therapeutic effects of the delivered drug while…”
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Ecdysteroid Derivatives that Reverse P‑Glycoprotein-Mediated Drug Resistance
Published in Journal of natural products (Washington, D.C.) (28-08-2020)“…The expression of multidrug resistance P-glycoprotein (P-gp) by cancer cells represents one of the major drawbacks to successful cancer therapy. Accordingly,…”
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Istaroxime Metabolite PST3093 Selectively Stimulates SERCA2a and Reverses Disease-Induced Changes in Cardiac Function
Published in The Journal of pharmacology and experimental therapeutics (01-01-2023)“…Heart failure (HF) therapeutic toolkit would strongly benefit from the availability of ino-lusitropic agents with a favorable pharmacodynamics and safety…”
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Phytosterol and γ‑Oryzanol Conjugates: Synthesis and Evaluation of their Antioxidant, Antiproliferative, and Anticholesterol Activities
Published in Journal of natural products (Washington, D.C.) (26-10-2018)“…Fifteen new multifunctional conjugates were designed and synthesized by chemically linking the steroidal framework of natural occurring γ-oryzanol and…”
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Synthetic Glycolipids as Molecular Vaccine Adjuvants: Mechanism of Action in Human Cells and In Vivo Activity
Published in Journal of medicinal chemistry (26-08-2021)“…Modern adjuvants for vaccine formulations are immunostimulating agents whose action is based on the activation of pattern recognition receptors (PRRs) by…”
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Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure
Published in Journal of medicinal chemistry (26-05-2022)“…The stimulation of sarcoplasmic reticulum calcium ATPase SERCA2a emerged as a novel therapeutic strategy to efficiently improve overall cardiac function in…”
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Istaroxime follow-on compounds: A new class of selective SERCA2a activators for chronic heart failure treatment
Published in Vascular pharmacology (01-06-2024)Get full text
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Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis
Published in European journal of clinical pharmacology (01-03-2020)“…Purpose The partial ineffectiveness and side effects of inflammatory bowel disease (IBD) current therapies drive basic research to look for new therapeutic…”
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Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function
Published in Vascular pharmacology (01-10-2022)Get full text
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11
A Highly Sensitive Luminescent Biosensor for the Microvolumetric Detection of the Pseudomonas aeruginosa Siderophore Pyochelin
Published in ACS sensors (24-09-2021)“…The pyochelin (PCH) siderophore produced by the pathogenic bacterium Pseudomonas aeruginosa is an important virulence factor, acting as a growth promoter…”
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