Search Results - "Lupo, Audrey"

Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer by Giraldo, Nicolas A, Becht, Etienne, Pagès, Franck, Skliris, Georgios, Verkarre, Virginie, Vano, Yann, Mejean, Arnaud, Saint-Aubert, Nicolas, Lacroix, Laetitia, Natario, Ivo, Lupo, Audrey, Alifano, Marco, Damotte, Diane, Cazes, Aurelie, Triebel, Frederic, Freeman, Gordon J, Dieu-Nosjean, Marie-Caroline, Oudard, Stephane, Fridman, Wolf H, Sautès-Fridman, Catherine

“…Clear cell renal cell carcinoma (ccRCC) has shown durable responses to checkpoint blockade therapies. However, important gaps persist in the understanding of…”
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Body Mass Index and Total Psoas Area Affect Outcomes In Patients Undergoing Pneumonectomy for Cancer by Hervochon, Remi, MD, Bobbio, Antonio, MD, PhD, Guinet, Claude, MD, PhD, Mansuet-Lupo, Audrey, MD, PhD, Rabbat, Antoine, MD, Régnard, Jean-François, MD, Roche, Nicolas, MD, PhD, Damotte, Diane, MD, PhD, Iannelli, Antonio, MD, PhD, Alifano, Marco, MD, PhD

“…Background Hypothesizing that morphometric measurements are reliable markers of fitness in patients with lung cancer requiring aggressive surgical…”
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Pre-Disease and Pre-Surgery BMI, Weight Loss and Sarcopenia Impact Survival of Resected Lung Cancer Independently of Tumor Stage by Icard, Philippe, Schussler, Olivier, Loi, Mauro, Bobbio, Antonio, Lupo, Audrey Mansuet, Wislez, Marie, Iannelli, Antonio, Fournel, Ludovic, Damotte, Diane, Alifano, Marco

“…Lower pre-surgery Body Mass Index (BMI) and low muscle mass impact negatively long-term survival of non-small cell lung cancer (NSCLC). We investigated their…”
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Characteristics and Clinical Impacts of the Immune Environments in Colorectal and Renal Cell Carcinoma Lung Metastases: Influence of Tumor Origin by REMARK, Romain, ALIFANO, Marco, FLEJOU, Jean-François, GIBAULT, Laure, VERKARRE, Virginie, REGNARD, Jean-François, PAGES, Olivier-Nicolas, OUDARD, Stéphane, MLECNIK, Bernhard, SAUTES-FRIDMAN, Catherine, FRIDMAN, Wolf-Herman, DAMOTTE, Diane, CREMER, Isabelle, LUPO, Audrey, DIEU-NOSJEAN, Marie-Caroline, RIQUET, Marc, CROZET, Lucile, OUAKRIM, Hanane, GOC, Jeremy, CAZES, Aurélie

“…If immune cells are involved in tumor surveillance and have a prognostic impact in most primary tumors, little is known about their significance in metastases…”
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Pericardial effusion under nivolumab: case-reports and review of the literature by Saade, Anastasia, Mansuet-Lupo, Audrey, Arrondeau, Jennifer, Thibault, Constance, Mirabel, Mariana, Goldwasser, François, Oudard, Stéphane, Weiss, Laurence

“…BackgroundNivolumab, a programmed death-1 (PD-1) inhibitor, is an immune checkpoint inhibitor particularly used in the treatment of malignant melanoma,…”
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Subsolid Lung Nodule Classification: A CT Criterion for Improving Interobserver Agreement by Revel, Marie-Pierre, Mannes, Inès, Benzakoun, Joseph, Guinet, Claude, Léger, Thomas, Grenier, Philippe, Lupo, Audrey, Fournel, Ludovic, Chassagnon, Guillaume, Bommart, Sébastien

“…Purpose To evaluate an objective computed tomographic (CT) criterion for distinguishing between part-solid (PS) and nonsolid (NS) lung nodules. Materials and…”
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Thoracic Endometriosis Syndrome Other Than Pneumothorax: Clinical and Pathological Findings by Bobbio, Antonio, Canny, Emeline, Mansuet Lupo, Audrey, Lococo, Filippo, Legras, Antoine, Magdeleinat, Pierre, Regnard, Jean-François, Gompel, Anne, Damotte, Diane, Alifano, Marco

“…Thoracic endometriosis syndrome refers to a broad spectrum of clinical manifestations related to the presence of ectopic intrathoracic endometrial tissue. Few…”
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TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer by Chatterjee, Saradiya, Crozet, Lucile, Damotte, Diane, Iribarren, Kristina, Schramm, Catherine, Alifano, Marco, Lupo, Audrey, Cherfils-Vicini, Julien, Goc, Jeremy, Katsahian, Sandrine, Younes, Mohammad, Dieu-Nosjean, Marie Caroline, Fridman, Wolf Herman, Sautès-Fridman, Catherine, Cremer, Isabelle

“…Toll-like receptors (TLR) recognize pathogen molecules and danger-associated signals that stimulate inflammatory processes. TLRs have been studied mainly in…”
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Micronodular thymic carcinoma with lymphoid hyperplasia: relevance of immunohistochemistry with a small panel of antibodies for diagnosis—a RYTHMIC study by Thomas de Montpreville, Vincent, Mansuet-Lupo, Audrey, Le Naoures, Cécile, Chalabreysse, Lara, De Muret, Anne, Hofman, Véronique, Rouquette, Isabelle, Piton, Nicolas, Dubois, Romain, Benitez, Jose Carlos, Girard, Nicolas, Besse, Benjamin, Marx, Alexander, Molina, Thierry Jo

“…Micronodular thymic carcinoma with lymphoid hyperplasia (MNTCLH) is a rare form of thymic carcinoma. We present the experience of RYTHMIC, the French national…”
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The New Histologic Classification of Lung Primary Adenocarcinoma Subtypes Is a Reliable Prognostic Marker and Identifies Tumors With Different Mutation Status by Mansuet-Lupo, Audrey, MD, Bobbio, Antonio, MD, PhD, Blons, Hélène, PharmD, PhD, Becht, Etienne, Ouakrim, Hanane, Didelot, Audrey, Charpentier, Marie-Christine, MD, Bain, Serge, Marmey, Béatrice, Bonjour, Patricia, Biton, Jérôme, PhD, Cremer, Isabelle, PhD, Dieu-Nosjean, Marie-Caroline, PhD, Sautès-Fridman, Catherine, PhD, Régnard, Jean-François, MD, Laurent-Puig, Pierre, MD, PhD, Alifano, Marco, MD, PhD, FCCP, Damotte, Diane, MD, PhD

“…BACKGROUND Histologic classification of lung adenocarcinoma subtype has a prognostic value in most studies. However, lung adenocarcinoma characteristics differ…”
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Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions by Russick, Jules, Joubert, Pierre-Emmanuel, Gillard-Bocquet, Mélanie, Torset, Carine, Meylan, Maxime, Petitprez, Florent, Dragon-Durey, Marie-Agnes, Marmier, Solenne, Varthaman, Aditi, Josseaume, Nathalie, Germain, Claire, Goc, Jérémy, Dieu-Nosjean, Marie-Caroline, Validire, Pierre, Fournel, Ludovic, Zitvogel, Laurence, Bindea, Gabriela, Lupo, Audrey, Damotte, Diane, Alifano, Marco, Cremer, Isabelle

“…BackgroundNatural killer (NK) cells play a crucial role in tumor immunosurveillance through their cytotoxic effector functions and their capacity to interact…”
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Immune contexture and histological response after neoadjuvant chemotherapy predict clinical outcome of lung cancer patients by Remark, Romain, Lupo, Audrey, Alifano, Marco, Biton, Jerome, Ouakrim, Hanane, Stefani, Alessandro, Cremer, Isabelle, Goc, Jeremy, Régnard, Jean-Francois, Dieu-Nosjean, Marie-Caroline, Damotte, Diane

“…There is now growing evidence that the immune contexture influences cancer progression and clinical outcome of patients with non-small cell lung cancer…”
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Multiplex picoliter-droplet digital PCR for quantitative assessment of DNA integrity in clinical samples by Didelot, Audrey, Kotsopoulos, Steve K, Lupo, Audrey, Pekin, Deniz, Li, Xinyu, Atochin, Ivan, Srinivasan, Preethi, Zhong, Qun, Olson, Jeff, Link, Darren R, Laurent-Puig, Pierre, Blons, Hélène, Hutchison, J Brian, Taly, Valerie

“…Assessment of DNA integrity and quantity remains a bottleneck for high-throughput molecular genotyping technologies, including next-generation sequencing. In…”
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TP53, STK11 , and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma by Biton, Jérôme, Mansuet-Lupo, Audrey, Pécuchet, Nicolas, Alifano, Marco, Ouakrim, Hanane, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Goldwasser, François, Leroy, Karen, Goc, Jeremy, Wislez, Marie, Germain, Claire, Laurent-Puig, Pierre, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Herbst, Ronald, Blons, Hélène, Damotte, Diane

“…By unlocking antitumor immunity, antibodies targeting programmed cell death 1 (PD-1) exhibit impressive clinical results in non-small cell lung cancer,…”
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Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells by Dajon, Marion, Iribarren, Kristina, Petitprez, Florent, Marmier, Solenne, Lupo, Audrey, Gillard, Mélanie, Ouakrim, Hanane, Victor, Navas, Vincenzo, Di Bartolo, Joubert, Pierre Emmanuel, Kepp, Oliver, Kroemer, Guido, Alifano, Marco, Damotte, Diane, Cremer, Isabelle

“…In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and…”
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Updated Prognostic Factors in Localized NSCLC by Garinet, Simon, Wang, Pascal, Mansuet-Lupo, Audrey, Fournel, Ludovic, Wislez, Marie, Blons, Hélène

“…Lung cancer is the most common cause of cancer mortality worldwide, and non-small cell lung cancer (NSCLC) represents 80% of lung cancer subtypes. Patients…”
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Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib by Younes, Mohamad, Wu, Zherui, Dupouy, Sandra, Lupo, Audrey Mansuet, Mourra, Najat, Takahashi, Takashi, Fléjou, Jean François, Trédaniel, Jean, Régnard, Jean François, Damotte, Diane, Alifano, Marco, Forgez, Patricia

“…Alterations in the signaling pathways of epidermal growth factor receptors (HERs) are associated with tumor aggressiveness. Neurotensin (NTS) and its high…”
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Lung Cancer That Harbors an HER2 Mutation: Epidemiologic Characteristics and Therapeutic Perspectives by Mazières, Julien, Peters, Solange, Lepage, Benoit, Cortot, Alexis B., Barlesi, Fabrice, Beau-Faller, Michéle, Besse, Benjamin, Blons, Hélène, Mansuet-Lupo, Audrey, Urban, Thierry, Moro-Sibilot, Denis, Dansin, Eric, Chouaid, Christos, Wislez, Marie, Diebold, Joachim, Felip, Enriqueta, Rouquette, Isabelle, Milia, Julie D., Gautschi, Oliver

“…HER2 mutations are identified in approximately 2%of non-small-cell lung cancers (NSCLC). There are few data available that describe the clinical course of…”
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Detection of Nine Oncogenes Amplification in Lung and Colorectal Cancer Formalin-Fixed Paraffin-Embedded Tissue Samples using Combined Next-Generation Sequencing-Based Script and Digital Droplet Polymerase Chain Reaction by Bontoux, Christophe, Guyard, Alice, Lupo, Audrey, Diallo, Karim, Rebah, Khedidja, Hercent, Agathe, Guenzi, Edouard, Cros, Jérome, Lamoril, Jérome, Leroy, Karen, Theou-Anton, Nathalie

“…Introduction Gene copy number variations have theranostic impact and require reliable methods for their identification. We aimed to evaluate the reliability of…”
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Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells by Bennett Saidu, Nathaniel Edward, Bretagne, Marie, Mansuet, Audrey Lupo, Just, Pierre-Alexandre, Leroy, Karen, Cerles, Olivier, Chouzenoux, Sandrine, Nicco, Carole, Damotte, Diane, Alifano, Marco, Borghese, Bruno, Goldwasser, François, Batteux, Frédéric, Alexandre, Jérôme

“…KRAS mutation, one of the most common molecular alterations observed in adult carcinomas, was reported to activate the anti-oxidant program driven by the…”
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