Search Results - "Lupisella, John A."

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment by García, Ricardo A., Ito, Bruce R., Lupisella, John A., Carson, Nancy A., Hsu, Mei-Yin, Fernando, Gayani, Heroux, Madeleine, Bouvier, Michel, Dierks, Elizabeth, Kick, Ellen K., Gordon, David A., Chen, Jian, Mintier, Gabe, Carrier, Marilyn, St-Onge, Stéphane, Shah, Himanshu, Towne, Jordan, Bucardo, Marcela Sotelo, Ma, Xiuying, Ryan, Carol S., Wurtz, Nicholas R., Ostrowski, Jacek, Villarreal, Francisco J.

“…[Display omitted] •Myocardial infarction leads to recruitment of monocyte/macrophages to the injured myocardium to drive infarct healing.•Activation of formyl…”
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11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice by García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A

“…Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11β-hydroxysteroid…”
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Formyl peptide receptor 2 and heart disease by Lupisella, John A., Shirude, Pravin S., Wurtz, Nicholas R., Garcia, Ricardo A.

“…Formyl peptide receptor type 2 (FPR2) regulates the initiation and resolution phases of the inflammatory response. In the setting of heart injury and disease,…”
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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold by Sun, Chongqing, Robl, Jeffrey A, Wang, Tammy C, Huang, Yanting, Kuhns, Joyce E, Lupisella, John A, Beehler, Blake C, Golla, Rajasree, Sleph, Paul G, Seethala, Ramakrishna, Fura, Aberra, Krystek, Stanley R, An, Yongmi, Malley, Mary F, Sack, John S, Salvati, Mark E, Grover, Gary J, Ostrowski, Jacek, Hamann, Lawrence G

“…A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator scaffold was discovered through structure-guided modifications of androgen receptor…”
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Discovery and Optimization of Aryl Piperidinone Ureas as Selective Formyl Peptide Receptor 2 Agonists by Wurtz, Nicholas R, Shirude, Pravin S, Cheney, Daniel L, Lupisella, John A, Chattopadhyay, Amit Kumar, Baligar, Vishweshwaraiah, Seshadri, Balaji, Anjanappa, Prakash, Viet, Andrew, Valente, Meriah N, Hsu, Mei-Yin, Abousleiman, Mojgan, Sarodaya, Sanket, Tagore, Debarati M, Dudhgaonkar, Shailesh, Putlur, Sivaprasad, Dierks, Elizabeth A, Ostrowski, Jacek, Wexler, Ruth R, Garcia, Ricardo, Kick, Ellen K

“…We report the discovery and optimization of aryl piperidinone urea formyl peptide receptor 2 (FPR2) agonists from a weakly active high-throughput screening…”
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Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists by Wurtz, Nicholas R., Johnson, James A., Viet, Andrew, Shirude, Pravin S., Baligar, Vishweshwaraiah, Madduri, Sudhakara, Cheney, Daniel L., Park, Hyunsoo, Lupisella, John A., Hsu, Mei-Yin, Abousleiman, Mojgan, Galella, Michael A., Aulakh, Darpandeep, Dierks, Elizabeth A., Garcia, Ricardo A., Ostrowski, Jacek, Kick, Ellen K., Wexler, Ruth R.

“…Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases…”
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Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction by García, Ricardo A., Lupisella, John A., Ito, Bruce R., Hsu, Mei-Yin, Fernando, Gayani, Carson, Nancy L., Allocco, John J., Ryan, Carol S., Zhang, Rongan, Wang, Zhaoqing, Heroux, Madeleine, Carrier, Marilyn, St.-Onge, Stéphane, Bouvier, Michel, Dudhgaonkar, Shailesh, Nagar, Jignesh, Bustamante-Pozo, Moises M., Garate-Carrillo, Alejandra, Chen, Jian, Ma, Xiuying, Search, Debra J., Dierks, Elizabeth A., Kick, Ellen K., Wexler, Ruth R., Gordon, David A., Ostrowski, Jacek, Wurtz, Nicholas R., Villarreal, Francisco

“…[Display omitted] •MI leads to ischemic damage of myocardium and activation of inflammatory programs as part of the wound healing response.•Selective…”
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Inhibition of disease progression by a novel retinoid antagonist in animal models of arthritis by BEEHLER, Blake C, HEI, Yong-Jiang, CHEN, Simon, LUPISELLA, John A, OSTROWSKI, Jacek, STARRETT, John E, TORTOLANI, David, TRAMPOSCH, Kenneth M, RECZEK, Peter R

“…OBJECTIVE: To investigate the usefulness of a novel retinoic acid receptor (RAR) antagonist (BMS-189453) in animal models of arthritis. METHODS: BMS-189453 was…”
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Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats by Ostrowski, Jacek, Kuhns, Joyce E, Lupisella, John A, Manfredi, Mark C, Beehler, Blake C, Krystek, Stanley R, Bi, Yingzhi, Sun, Chongqing, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Fura, Aberra, An, Yongmi, Kish, Kevin F, Sack, John S, Mookhtiar, Kasim A, Grover, Gary J, Hamann, Lawrence G

“…A novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator (BMS-564929) has been identified, and this compound has…”
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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation by Nirschl, Alexandra A, Zou, Yan, Krystek, Stanley R, Sutton, James C, Simpkins, Ligaya M, Lupisella, John A, Kuhns, Joyce E, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Egan, Donald, Fura, Aberra, Vyas, Viral P, Li, Yi-Xin, Sack, John S, Kish, Kevin F, An, Yongmi, Bryson, James A, Gougoutas, Jack Z, DiMarco, John, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G

“…A novel selective androgen receptor modulator (SARM) scaffold was discovered as a byproduct obtained during synthesis of our earlier series of…”
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Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators by Hamann, Lawrence G., Manfredi, Mark C., Sun, Chongqing, Krystek, Stanley R., Huang, Yanting, Bi, Yingzhi, Augeri, David J., Wang, Tammy, Zou, Yan, Betebenner, David. A., Fura, Aberra, Seethala, Ramakrishna, Golla, Rajasree, Kuhns, Joyce E., Lupisella, John A., Darienzo, Celia J., Custer, Laura L., Price, Jennifer L., Johnson, James M., Biller, Scott A., Zahler, Robert, Ostrowski, Jacek

“…SAR relating to the optimization of androgen receptor agonist activity and elimination of mutagenic potential is reported. Pharmacokinetic studies in…”
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11[beta]-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic apoE.sup.-/- Mice by García, Ricardo A, Search, Debra J, Lupisella, John A, Ostrowski, Jacek, Guan, Bo, Chen, Jian, Yang, Wen-Pin, Truong, Amy, He, Aiqing, Zhang, Rongan, Yan, Mujing, Hellings, Samuel E, Gargalovic, Peter S, Ryan, Carol S, Watson, Linda M, Langish, Robert A, Shipkova, Petia A, Carson, Nancy L, Taylor, Joseph R, Yang, Richard, Psaltis, George C, Harrity, Thomas W, Robl, Jeffrey A, Gordon, David A

“…Background Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme…”
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Ligand-induced Conformational Changes in the Human Retinoic Acid Receptor γ Detected Using Monoclonal Antibodies by Joyce E. Driscoll, Carrie L. Seachord, John A. Lupisella, Richard P. Darveau, Peter R. Reczek

“…The mechanism by which the naturally occurring ligand for a nuclear hormone receptor regulates transcription remains largely unknown. One approach combines the…”
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The Ligand Binding Domain of the Human Retinoic Acid Receptor γ Is Predominantly α-Helical with a Trp Residue in the Ligand Binding Site (∗) by Lupisella, John A., Driscoll, Joyce E., Metzler, William J., Reczek, Peter R.

“…Retinoic acid exerts its many biological effects by interaction with a nuclear protein, the retinoic acid receptor (RAR). The details of this interaction are…”
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The Ligand Binding Domain of the Human Retinoic Acid Receptor Is Predominantly -Helical with a Trp Residue in the Ligand Binding Site by John A. Lupisella, Joyce E. Driscoll, William J. Metzler, Peter R. Reczek

“…Retinoic acid exerts its many biological effects by interaction with a nuclear protein, the retinoic acid receptor (RAR). The details of this interaction are…”
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Ligand-induced Conformational Changes in the Human Retinoic Acid Receptor γ Detected Using Monoclonal Antibodies by Driscoll, Joyce E., Seachord, Carrie L., Lupisella, John A., Darveau, Richard P., Reczek, Peter R.

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Protein synthesis in yeast. Structural and functional analysis of the gene encoding elongation factor 3 by SANDBAKEN, M. G, KUPISELLA, J. A, DIDOMENICO, B, CHAKRABURTTY, K

“…The yeast translational elongation factor 3 (EF-3) stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome. The requirement for EF-3 is…”
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