Search Results - "Luoto, Kaisa"

Tumor hypoxia as a driving force in genetic instability by Luoto, Kaisa R, Kumareswaran, Ramya, Bristow, Robert G

“…Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase…”
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Predictors of short-term response and the role of heavy alcohol use in treatment of depression by Luoto, Kaisa E, Lassila, Antero, Leinonen, Esa, Kampman, Olli

“…Depression and alcohol use disorders frequently co-occur. However, research on psychosocial interventions for treating this dual pathology is limited. The…”
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Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment by CHAN, Norman, PIRES, Isabel M, HAMMOND, Ester M, BRISTOW, Robert G, BENCOKOVA, Zuzana, COACKLEY, Carla, LUOTO, Kaisa R, BHOGAL, Nirmal, LAKSHMAN, Minalini, GOTTIPATI, Ponnari, OLIVER, F. Javier, HELLEDAY, Thomas

“…Acute and chronic hypoxia exists within the three-dimensional microenvironment of solid tumors and drives therapy resistance, genetic instability, and…”
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Clozapine-Related Diarrhea and Colitis: Report of 4 Cases by Rask, Susanna Maria, Luoto, Kaisa E., Solismaa, Anssi, Jokinen, Elina, Jussila, Airi, Kampman, Olli

“…During clozapine treatment, diarrhea is a rare but clinically relevant adverse effect. Cases of microscopic colitis and eosinophilic colitis have been…”
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PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy by FRASER, Michael, HELEN ZHAO, BRISTOW, Robert G, LUOTO, Kaisa R, LUNDIN, Cecilia, COACKLEY, Carla, CHAN, Norman, JOSHUA, Anthony M, BISMAR, Tarek A, EVANS, Andrew, HELLEDAY, Thomas

“…PTEN deletions in prostate cancer are associated with tumor aggression and poor outcome. Recent studies have implicated PTEN as a determinant of homologous…”
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Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair by LUOTO, Kaisa R, MENG, Alice X, WASYLISHEN, Amanda R, ZHAO, Helen, COACKLEY, Carla L, PENN, Linda Z, BRISTOW, Robert G

“…MYC regulates a myriad of genes controlling cell proliferation, metabolism, differentiation, and apoptosis. MYC also controls the expression of DNA…”
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Behavioral activation versus treatment as usual in naturalistic sample of psychiatric patients with depressive symptoms: a benchmark controlled trial by Luoto, Kaisa E, Lindholm, Lars H, Paavonen, Vesa, Koivukangas, Antti, Lassila, Antero, Leinonen, Esa, Kampman, Olli

“…More systematic use of evidence-based brief therapies is needed in the treatment of depression within psychiatric care. The aim of this study was to explore…”
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Outcome of patients with dual diagnosis in secondary psychiatric care by Luoto, Kaisa E., Koivukangas, Antti, Lassila, Antero, Kampman, Olli

“…Background: Dual diagnosis (DD) is a common co-morbidity of mental illness and substance use disorder (SUD) and patients with DD are prone to complications…”
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The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombination by Zhao, Helen, Luoto, Kaisa R, Meng, Alice X, Bristow, Robert G

“…Abstract Background and purpose RAD51 is a key protein involved in homologous recombination (HR) and a potential target for radiation- and chemotherapies…”
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Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease by Vartiainen, Suvi, Chen, Shanjun, George, Jack, Tuomela, Tea, Luoto, Kaisa R, O'Dell, Kevin M C, Jacobs, Howard T

“…A point mutation in the Drosophila gene that codes for the major adult isoform of adenine nuclear translocase (ANT) represents a model for human diseases that…”
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Impact of Comorbid Alcohol Use Disorder on Health-Related Quality of Life Among Patients With Depressive Symptoms by Luoto, Kaisa E., Lindholm, Lars H., Koivukangas, Antti, Lassila, Antero, Sintonen, Harri, Leinonen, Esa, Kampman, Olli

“…Background and Aim: In psychiatric clinical practice, comorbidity of depression and alcohol use disorder (AUD) is common. Both disorders have a negative impact…”
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technical knockout, a Drosophila Model of Mitochondrial Deafness by Toivonen, Janne M, O'Dell, Kevin M. C, Petit, Nathalie, Irvine, Sharon C, Knight, Gillian K, Lehtonen, Marjo, Longmuir, Mark, Luoto, Kaisa, Touraille, Sylvie, Wang, Zongsheng, Alziari, Serge, Shah, Zahid H, Jacobs, Howard T

“…Mutations in mtDNA-encoded components of the mitochondrial translational apparatus are associated with diverse pathological states in humans, notably…”
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Temperament clusters associate with anxiety disorder comorbidity in depression by Paavonen, Vesa, Luoto, Kaisa, Lassila, Antero, Leinonen, Esa, Kampman, Olli

“…•Four temperament clusters were found in depressed patients.•Novelty seekers temperament was associated with panic disorder.•Wearied temperament was associated…”
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Temperament and character profiles are associated with depression outcome in psychiatric secondary care patients with harmful drinking by Paavonen, Vesa, Luoto, Kaisa, Lassila, Antero, Leinonen, Esa, Kampman, Olli

“…Temperament and character profiles have been associated with depression outcome and alcohol abuse comorbidity in depressed patients. How harmful alcohol use…”
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Enhancing the implementation of evidence-based treatment interventions. A comprehensive evaluation of a real-world implementation programme by Lindholm, Lars, Luoto, Kaisa, Laitila, Minna, Koivukangas, Antti, Lassila, Antero, Komulainen, Jorma, Kampman, Olli

“…Ostrobothnia Depression Programme (ODP) was conducted in South Ostrobothnia Hospital District in Finland 2009-2014. It was targeted to tackle heterogeneous…”
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Temperament and character profiles associated with depression and treatment response in patients with or without comorbid substance abuse by Paavonen, Vesa, Luoto, Kaisa, Koivukangas, Antti, Lassila, Antero, Leinonen, Esa, Kampman, Olli

“…Abstract There is limited knowledge on the relationship between temperament and character profiles and substance abuse comorbidity in depressed patients. We…”
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Status of inflammation and alcohol use in a 6-month follow-up study of patients with major depressive disorder by Archer, Mari, Niemelä, Onni, Luoto, Kaisa, Kultti, Johanna, Hämäläinen, Mari, Moilanen, Eeva, Koivukangas, Antti, Leinonen, Esa, Kampman, Olli

“…The studies on the relationship between alcohol consumption, the status of inflammation, and depression have produced conflicting results. In this study, we…”
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Assessment of alcohol consumption in depression follow-up using self-reports and blood measures including inflammatory biomarkers by Archer, Mari, Kampman, Olli, Bloigu, Aini, Bloigu, Risto, Luoto, Kaisa, Kultti, Johanna, Hämäläinen, Mari, Moilanen, Eeva, Leinonen, Esa, Niemelä, Onni

“…Alcohol consumption has been suggested a major role in the pathogenesis and prognosis of depression. However, reliable identification of hazardous drinking…”
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Detection of Experimental Colorectal Peritoneal Metastases by a Novel PDGFRβ-Targeting Nanobody by Strating, Esther, Elias, Sjoerd, van Scharrenburg, Guus, Luoto, Kaisa, Verheem, André, Borel Rinkes, Inne, Steen, Herman, Kranenburg, Onno

“…Peritoneal metastases in colorectal cancer (CRC) belong to Consensus Molecular Subtype 4 (CMS4) and are associated with poor prognosis. Conventional imaging…”
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Outcome of patients with dual diagnosis in secondary psychiatric care by Luoto, Kaisa E, Koivukangas, Antti, Lassila, Antero, Kampman, Olli

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