Search Results - "Luo, Meihua"

Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors by Li, Gang, Qi, Wenqing, Li, Xiaoxun, Zhao, Jinwu, Luo, Meihua, Chen, Jianjun

“…c-Jun N-Terminal Kinases (JNKs), members of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway, play a key role in the pathogenesis of many diseases…”
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Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space by Sheykhzadeh, Sana, Luo, Meihua, Peng, Bo, White, Jacinta, Abdalla, Youssef, Tang, Tweety, Mäkilä, Ermei, Voelcker, Nicolas H., Tong, Wing Yin

“…Mortality of glioblastoma multiforme (GBM) has not improved over the last two decades despite medical breakthroughs in the treatment of other types of cancers…”
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Targeting the NCOA3-SP1-TERT axis for tumor growth in hepatocellular carcinoma by Li, Wenbin, Yan, Yue, Zheng, Zongheng, Zhu, Qiaohua, Long, Qian, Sui, Silei, Luo, Meihua, Chen, Miao, Li, Yizhuo, Hua, Yijun, Deng, Wuguo, Lai, Renchun, Li, Liren

“…Hepatocellular carcinoma (HCC) has a high mortality rate and lacks an effective therapeutic target. Elevated expression of human telomerase reverse…”
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Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer by Liu, Yonggang, Zhou, Minyu, Wu, Jianhua, Wen, Zhaowei, Fang, Yisheng, Lin, Li, Luo, Meihua, Sun, Li, Liao, Wangjun

“…Background Gastric cancer (GC) is one of the most prevalent malignancy around the world. Primary tumor cells are enabled to invade and migrate into adjacent…”
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Redox regulation of DNA repair: implications for human health and cancer therapeutic development by Luo, Meihua, He, Hongzhen, Kelley, Mark R, Georgiadis, Millie M

“…Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct…”
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Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases by Luo, Meihua, Lee, Leo Kit Cheung, Peng, Bo, Choi, Chung Hang Jonathan, Tong, Wing Yin, Voelcker, Nicolas H.

“…Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD), Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still…”
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Effectiveness of porous silicon nanoparticle treatment at inhibiting the migration of a heterogeneous glioma cell population by Abdalla, Youssef, Luo, Meihua, Mäkilä, Ermei, Day, Bryan W, Voelcker, Nicolas H, Tong, Wing Yin

“…Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that…”
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APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival by Cardoso, Angelo A, Jiang, Yanlin, Luo, Meihua, Reed, April M, Shahda, Safi, He, Ying, Maitra, Anirban, Kelley, Mark R, Fishel, Melissa L

“…Pancreatic cancer is a largely incurable disease, and increasing evidence supports strategies targeting multiple molecular mediators of critical functions of…”
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Percutaneous endovenous intervention without vena cava filter for acute proximal deep vein thrombosis secondary to iliac vein compression syndrome: preliminary outcomes by Zhu, Qiaohua, Chen, Dehua, Zhou, Chengyu, Luo, Meihua, Huang, Wei, Huang, Jiangyuan, Huang, Junyong, Chen, Yong

“…The aim is to report the preliminary outcomes of percutaneous endovenous intervention (PEVI) for acute proximal deep vein thrombosis (DVT) secondary to iliac…”
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Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas by Wang, Jingshu, Zou, Kun, Feng, Xu, Chen, Miao, Li, Cong, Tang, Ranran, Xuan, Yang, Luo, Meihua, Chen, Wangbing, Qiu, Huijuan, Qin, Ge, Li, Yixin, Zhang, Changlin, Xiao, Binyi, Kang, Lan, Kang, Tiebang, Huang, Wenlin, Yu, Xinfa, Wu, Xiaojun, Deng, Wuguo

“…N-myc (and STAT) interactor (NMI) plays vital roles in tumor growth, progression, and metastasis. In this study, we identified NMI as a potential tumor…”
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Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: Enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition by Wang, Dong, Luo, Meihua, Kelley, Mark R

“…Osteosarcoma is the most common highly malignant bone tumor with primary appearance during the second and third decade of life. It is associated with a high…”
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Capsular Polysaccharide From Bacteroides fragilis Protects Against Ulcerative Colitis in an Undegraded Form by Zheng, Lijun, Luo, Meihua, Kuang, Gaobo, Liu, Yangyang, Liang, Debao, Huang, Haiqing, Yi, Xiaomin, Wang, Congfeng, Wang, Ye, Xie, Qiuling, Zhi, Fachao

“…The prominent human symbiont protects animals from intestinal diseases, such as ulcerative colitis, and its capsular polysaccharide plays a key role in…”
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Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease by Luo, Meihua, Zhang, Jun, He, Hongzhen, Su, Dian, Chen, Qiujia, Gross, Michael L, Kelley, Mark R, Georgiadis, Millie M

“…Apurinic/apyrimidinic endonuclease (APE1) is an unusual nuclear redox factor in which the redox-active cysteines identified to date, C65 and C93, are surface…”
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Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells by Bapat, Aditi, Glass, Lateca S, Luo, Meihua, Fishel, Melissa L, Long, Eric C, Georgiadis, Millie M, Kelley, Mark R

“…Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is an essential DNA repair protein that plays a critical role in repair of AP sites via base excision repair…”
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MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation by Li, Yixin, Li, Liren, Chen, Miao, Yu, Xinfa, Gu, Zhuoyu, Qiu, Huijuan, Qin, Ge, Long, Qian, Fu, Xiaoyan, Liu, Tianze, Li, Wenbin, Huang, Wenlin, Shi, Dingbo, Kang, Tiebang, Luo, Meihua, Wu, Xiaojun, Deng, Wuguo

“…Nuclear receptor coactivator 3 (NCOA3) is a transcriptional coactivator that has elevated expression in multiple tumor types, including colorectal cancer…”
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Inhibition of the Human Apurinic/Apyrimidinic Endonuclease (Ape1) Repair Activity and Sensitization of Breast Cancer Cells to DNA Alkylating Agents with Lucanthone by Luo, Meihua, Kelley, Mark R

“…Cells repair DNA damage via four main mechanisms, however, damage induced by alkylators and oxidative damage is predominantly repaired by the DNA base excision…”
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Design and Synthesis of Novel Quinone Inhibitors Targeted to the Redox Function of Apurinic/Apyrimidinic Endonuclease 1/Redox Enhancing Factor-1 (Ape1/Ref-1) by Nyland, Rodney L, Luo, Meihua, Kelley, Mark R, Borch, Richard F

“…The multifunctional enzyme apurinic endonuclease 1/redox enhancing factor 1 (Ape1/ref-1) maintains genetic fidelity through the repair of apurinic sites and…”
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Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1 by Luo, Meihua, Delaplane, Sarah, Jiang, Aihua, Reed, April, He, Ying, Fishel, Melissa, Nyland, 2nd, Rodney L, Borch, Richard F, Qiao, Xiaoxi, Georgiadis, Millie M, Kelley, Mark R

“…The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of…”
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RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways by Liu, Tianze, Wu, Xiaojun, Li, Yizhuo, Lu, Wenjing, Zheng, Fufu, Zhang, Changlin, Long, Qian, Qiu, Huijuan, Li, Yixin, Ge, Qin, Chen, Miao, Yu, Xinfa, Chen, Wangbing, Zhang, Hongyang, Huang, Wenlin, Luo, Meihua, Deng, Wuguo, Li, Liren

“…Background/Aims: RBFOX3, an RNA-binding fox protein, plays an important role in the differentiation of neuronal development, but its role in the…”
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Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway by Liu, Tianze, Jin, Lizi, Chen, Miao, Zheng, Zongheng, Lu, Wenjing, Fan, Wenhua, Li, Liren, Zheng, Fufu, Zhu, Qiaohua, Qiu, Huijuan, Liu, Jiani, Chen, Manyu, Tian, Chunfang, Hu, Zheng, Zhang, Changlin, Luo, Meihua, Li, Jian, Kang, Tiebang, Yang, Lukun, Li, Yizhuo, Deng, Wuguo

“…Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it is unclear whether Ku80 regulates tumor growth in…”
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