Search Results - "Luo, Jialie"

Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch by Feng, Jing, Luo, Jialie, Yang, Pu, Du, Junhui, Kim, Brian S, Hu, Hongzhen

“…The somatosensory system relays many signals ranging from light touch to pain and itch. Touch is critical to spatial awareness and communication. However, in…”
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Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch by Oetjen, Landon K., Mack, Madison R., Feng, Jing, Whelan, Timothy M., Niu, Haixia, Guo, Changxiong J., Chen, Sisi, Trier, Anna M., Xu, Amy Z., Tripathi, Shivani V., Luo, Jialie, Gao, Xiaofei, Yang, Lihua, Hamilton, Samantha L., Wang, Peter L., Brestoff, Jonathan R., Council, M. Laurin, Brasington, Richard, Schaffer, András, Brombacher, Frank, Hsieh, Chyi-Song, Gereau, Robert W., Miller, Mark J., Chen, Zhou-Feng, Hu, Hongzhen, Davidson, Steve, Liu, Qin, Kim, Brian S.

“…Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is well…”
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Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis by Chen, Zuojia, Luo, Jialie, Li, Jian, Kim, Girak, Stewart, Andy, Urban, Joseph F., Huang, Yuefeng, Chen, Shan, Wu, Ling-Gang, Chesler, Alexander, Trinchieri, Giorgio, Li, Wei, Wu, Chuan

“…The gastrointestinal tract is known as the largest endocrine organ that encounters and integrates various immune stimulations and neuronal responses due to…”
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Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling by Zhou, Yong, Wong, Ching-On, Cho, Kwang-jin, van der Hoeven, Dharini, Liang, Hong, Thakur, Dhananiay P., Luo, Jialie, Babic, Milos, Zinsmaier, Konrad E., Zhu, Michael X., Hu, Hongzhen, Venkatachalam, Kartik, Hancock, John F.

“…Plasma membrane depolarization can trigger cell proliferation, but how membrane potential influences mitogenic signaling is uncertain. Here, we show that…”
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Sensory TRP channels contribute differentially to skin inflammation and persistent itch by Feng, Jing, Yang, Pu, Mack, Madison R., Dryn, Dariia, Luo, Jialie, Gong, Xuan, Liu, Shenbin, Oetjen, Landon K., Zholos, Alexander V., Mei, Zhinan, Yin, Shijin, Kim, Brian S., Hu, Hongzhen

“…Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared…”
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Optogenetic Induction of Colonic Motility in Mice by Hibberd, Timothy J., Feng, Jing, Luo, Jialie, Yang, Pu, Samineni, Vijay K., Gereau, Robert W., Kelley, Nigel, Hu, Hongzhen, Spencer, Nick J.

“…Strategies are needed to increase gastrointestinal transit without systemic pharmacologic agents. We investigated whether optogenetics, focal application of…”
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Curcumin Improves Neurogenesis in Alzheimer's Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF by Lou, Shengchun, Gong, Danfeng, Yang, Mengting, Qiu, Qing, Luo, Jialie, Chen, Tingting

“…Adult neurogenesis in the dentate gyrus (DG) is impaired during Alzheimer's disease (AD) progression. Curcumin has been reported to reduce cell apoptosis and…”
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Transient receptor potential vanilloid 4–expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch by Luo, Jialie, Feng, Jing, Yu, Guang, Yang, Pu, Mack, Madison R., Du, Junhui, Yu, Weihua, Qian, Aihua, Zhang, Yujin, Liu, Shenbin, Yin, Shijin, Xu, Amy, Cheng, Jizhong, Liu, Qingyun, O'Neil, Roger G., Xia, Yang, Ma, Liang, Carlton, Susan M., Kim, Brian S., Renner, Kenneth, Liu, Qin, Hu, Hongzhen

“…Chronic itch is a highly debilitating symptom that underlies many medical disorders with no universally effective treatments. Although unique neuronal…”
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Zinc Inhibits TRPV1 to Alleviate Chemotherapy-Induced Neuropathic Pain by Luo, Jialie, Bavencoffe, Alexis, Yang, Pu, Feng, Jing, Yin, Shijin, Qian, Aihua, Yu, Weihua, Liu, Shenbin, Gong, Xuan, Cai, Tao, Walters, Edgar T, Dessauer, Carmen W, Hu, Hongzhen

“…Zinc is a transition metal that has a long history of use as an anti-inflammatory agent. It also soothes pain sensations in a number of animal models. However,…”
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TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells by Luo, Jialie, Qian, Aihua, Oetjen, Landon K., Yu, Weihua, Yang, Pu, Feng, Jing, Xie, Zili, Liu, Shenbin, Yin, Shijin, Dryn, Dari, Cheng, Jizhong, Riehl, Terrence E., Zholos, Alexander V., Stenson, William F., Kim, Brian S., Hu, Hongzhen

“…Intestinal macrophages are critical for gastrointestinal (GI) homeostasis, but our understanding of their role in regulating intestinal motility is incomplete…”
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Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion by Chen, Zuojia, Luo, Jialie, Li, Jian, Kim, Girak, Chen, Eric S, Xiao, Sheng, Snapper, Scott B, Bao, Bin, An, Dingding, Blumberg, Richard S, Lin, Cheng-Hui, Wang, Sui, Zhong, Jiaxin, Liu, Kuai, Li, Qiyuan, Wu, Chuan, Kuchroo, Vijay K

“…Mucus produced by goblet cells in the gastrointestinal tract forms a biological barrier that protects the intestine from invasion by commensals and pathogens…”
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Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes by Luo, Jialie, Stewart, Randi, Berdeaux, Rebecca, Hu, Hongzhen

“…The transient receptor potential vanilloid 3 channel (TRPV3) is abundantly expressed in epidermal keratinocytes and has important roles in sensory biology and…”
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Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity by Yin, Shijin, Luo, Jialie, Qian, Aihua, Du, Junhui, Yang, Qing, Zhou, Shentai, Yu, Weihua, Du, Guangwei, Clark, Richard B, Walters, Edgar T, Carlton, Susan M, Hu, Hongzhen

“…Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation. Clinically,…”
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Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons by Feng, Jing, Hibberd, Tim J, Luo, Jialie, Yang, Pu, Xie, Zili, Travis, Lee, Spencer, Nick J, Hu, Hongzhen

“…How the enteric nervous system determines the pacing and propagation direction of neurogenic contractions along the colon remains largely unknown. We used a…”
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The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice by Feng, Jing, Luo, Jialie, Mack, Madison R., Yang, Pu, Zhang, Feng, Wang, Guan, Gong, Xuan, Cai, Tao, Mei, Zhinan, Kim, Brian S., Yin, Shijin, Hu, Hongzhen

“…To the Editor: Chronic skin inflammation is considered the most prominent feature for clinical diagnosis of psoriasis, a long-lasting autoimmune disease…”
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Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction by Hu, Xia, Adebiyi, Morayo G., Luo, Jialie, Sun, Kaiqi, Le, Thanh-Thuy T., Zhang, Yujin, Wu, Hongyu, Zhao, Shushan, Karmouty-Quintana, Harry, Liu, Hong, Huang, Aji, Wen, Yuan Edward, Zaika, Oleg L., Mamenko, Mykola, Pochynyuk, Oleh M., Kellems, Rodney E., Eltzschig, Holger K., Blackburn, Michael R., Walters, Edgar T., Huang, Dong, Hu, Hongzhen, Xia, Yang

“…The molecular mechanisms of chronic pain are poorly understood and effective mechanism-based treatments are lacking. Here, we report that mice lacking…”
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NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel by Tian, Xiao Yu, Wong, Wing Tak, Sayed, Nazish, Luo, Jialie, Tsang, Suk Ying, Bian, Zhao Xiang, Lu, Ye, Cheang, Wai San, Yao, Xiaoqiang, Chen, Zhen Yu, Huang, Yu

“…H2S, a gaseous signalling molecule, relaxes blood vessels partly through activation of ATP-sensitive K+ channels. It is however unclear whether H2S or its…”
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The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice by Feng, Jing, PhD, Luo, Jialie, PhD, Mack, Madison R., BA, Yang, Pu, PhD, Zhang, Feng, BS, Wang, Guan, BS, Gong, Xuan, BS, Cai, Tao, MD, PhD, Mei, Zhinan, PhD, Kim, Brian S., MD, Yin, Shijin, PhD, Hu, Hongzhen, PhD

“…The psoriasis biomarker hBD2 produces a robust scratching response in a TLR4-dependent manner in mice. TRPV1 is a downstream mediator of hBD2-induced itch…”
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Bis(7)‐tacrine attenuates β amyloid‐induced neuronal apoptosis by regulating L‐type calcium channels by Fu, Hongjun, Li, Wenming, Lao, Yuanzhi, Luo, Jialie, Lee, Nelson T. K., Kan, Kelvin K. W., Tsang, Hing Wai, Tsim, Karl W. K., Pang, Yuanping, Li, Zhiwang, Chang, Donald C., Li, Mingtao, Han, Yifan

“…β Amyloid protein (Aβ) and acetylcholinesterase (AChE) have been shown to be closely implicated in the pathogenesis of Alzheimer's disease. In the current…”
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Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade by Cui, Wei, Hu, Shengquan, Chan, Hugh H.N., Luo, Jialie, Li, Wenming, Mak, Shinghung, Choi, Tony Chunglit, Rong, Jianhui, Carlier, Paul R., Han, Yifan

“…Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor…”
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