Search Results - "Lunstad, Benjamin D"

Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs by Mutisya, Daniel, Selvam, Chelliah, Lunstad, Benjamin D, Pallan, Pradeep S, Haas, Amanda, Leake, Devin, Egli, Martin, Rozners, Eriks

“…RNA interference (RNAi) has become an important tool in functional genomics and has an intriguing therapeutic potential. However, the current design of short…”
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Improving CRISPR-Cas specificity with chemical modifications in single-guide RNAs by Ryan, Daniel E, Taussig, David, Steinfeld, Israel, Phadnis, Smruti M, Lunstad, Benjamin D, Singh, Madhurima, Vuong, Xuan, Okochi, Kenji D, McCaffrey, Ryan, Olesiak, Magdalena, Roy, Subhadeep, Yung, Chong Wing, Curry, Bo, Sampson, Jeffrey R, Bruhn, Laurakay, Dellinger, Douglas J

“…Abstract CRISPR systems have emerged as transformative tools for altering genomes in living cells with unprecedented ease, inspiring keen interest in…”
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Phosphonoacetate Modifications Enhance the Stability and Editing Yields of Guide RNAs for Cas9 Editors by Ryan, Daniel E., Diamant-Levi, Tamar, Steinfeld, Israel, Taussig, David, Visal-Shah, Savita, Thakker, Suhani, Lunstad, Benjamin D., Kaiser, Robert J., McCaffrey, Ryan, Ortiz, Michael, Townsend, Justin, Welch, William R. W., Singh, Mandeep, Curry, Bo, Dellinger, Douglas J., Bruhn, Laurakay

“…CRISPR gene editing and control systems continue to emerge and inspire novel research and clinical applications. Advances in CRISPR performance such as…”
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Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells by Hendel, Ayal, Bak, Rasmus O, Clark, Joseph T, Kennedy, Andrew B, Ryan, Daniel E, Roy, Subhadeep, Steinfeld, Israel, Lunstad, Benjamin D, Kaiser, Robert J, Wilkens, Alec B, Bacchetta, Rosa, Tsalenko, Anya, Dellinger, Douglas, Bruhn, Laurakay, Porteus, Matthew H

“…Improved efficiency of CRISPR/Cas editing with chemically modified synthetic sgRNAs. CRISPR-Cas-mediated genome editing relies on guide RNAs that direct…”
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Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages by Tanui, Paul, Kennedy, Scott D, Lunstad, Benjamin D, Haas, Amanda, Leake, Devin, Rozners, Eriks

“…RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did…”
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