Search Results - "Lunova, Mariia"

Impact of mechanical cues on key cell functions and cell-nanoparticle interactions by Elblová, Petra, Lunova, Mariia, Dejneka, Alexandr, Jirsa, Milan, Lunov, Oleg

“…In recent years, it has been recognized that mechanical forces play an important regulative role in living organisms and possess a direct impact on crucial…”
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Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations by Lunova, Mariia, Smolková, Barbora, Uzhytchak, Mariia, Janoušková, Klára Žofie, Jirsa, Milan, Egorova, Daria, Kulikov, Andrei, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg

“…Biological effects of high fluence low-power (HFLP) lasers have been reported for some time, yet the molecular mechanisms procuring cellular responses remain…”
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Non-Thermal Plasma, as a New Physicochemical Source, to Induce Redox Imbalance and Subsequent Cell Death in Liver Cancer Cell Lines by Smolková, Barbora, Lunova, Mariia, Lynnyk, Anna, Uzhytchak, Mariia, Churpita, Olexander, Jirsa, Milan, Kubinová, Šárka, Lunov, Oleg, Dejneka, Alexandr

“…Alteration of cancer cell redox status has been recognized as a promising therapeutic implication. In recent years, the emerged field of non-thermal plasma…”
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Critical Analysis of Non-Thermal Plasma-Driven Modulation of Immune Cells from Clinical Perspective by Smolková, Barbora, Frtús, Adam, Uzhytchak, Mariia, Lunova, Mariia, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg

“…The emerged field of non-thermal plasma (NTP) shows great potential in the alteration of cell redox status, which can be utilized as a promising therapeutic…”
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Chemically different non-thermal plasmas target distinct cell death pathways by Lunov, Oleg, Zablotskii, Vitalii, Churpita, Olexander, Lunova, Mariia, Jirsa, Milan, Dejneka, Alexandr, Kubinová, Šárka

“…A rigorous biochemical analysis of interactions between non-thermal plasmas (NTPs) and living cells has become an important research topic, due to recent…”
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Sensitivity of endogenous autofluorescence in HeLa cells to the application of external magnetic fields by Uzhytchak, Mariia, Smolková, Barbora, Frtús, Adam, Stupakov, Alexandr, Lunova, Mariia, Scollo, Federica, Hof, Martin, Jurkiewicz, Piotr, Sullivan, Gareth John, Dejneka, Alexandr, Lunov, Oleg

“…Dramatically increased levels of electromagnetic radiation in the environment have raised concerns over the potential health hazards of electromagnetic fields…”
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Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines by Lunova, Mariia, Prokhorov, Andrey, Jirsa, Milan, Hof, Martin, Olżyńska, Agnieszka, Jurkiewicz, Piotr, Kubinová, Šárka, Lunov, Oleg, Dejneka, Alexandr

“…Specifically designed and functionalized nanoparticles hold great promise for biomedical applications. Yet, the applicability of nanoparticles is critically…”
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Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis by Frankova, Sona, Lunova, Mariia, Gottfriedova, Halima, Senkerikova, Renata, Neroldova, Magdalena, Kovac, Jozef, Kieslichova, Eva, Lanska, Vera, Urbanek, Petr, Spicak, Julius, Jirsa, Milan, Sperl, Jan

“…Liver stiffness is a reliable non-invasive predictor of Hepatic Venous Pressure Gradient (HVPG) above 10 mm Hg. However, it failed to predict higher thresholds…”
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Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling by Lunova, Mariia, Kubovciak, Jan, Smolková, Barbora, Uzhytchak, Mariia, Michalova, Kyra, Dejneka, Alexandr, Strnad, Pavel, Lunov, Oleg, Jirsa, Milan

“…Lambda interferons mediate antiviral immunity by inducing interferon-stimulated genes (ISGs) in epithelial tissues. A common variant rs368234815TT/∆G creating…”
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Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk by Rabekova, Zuzana, Frankova, Sona, Jirsa, Milan, Neroldova, Magdalena, Lunova, Mariia, Fabian, Ondrej, Kveton, Martin, Varys, David, Chmelova, Klara, Adamkova, Vera, Hubacek, Jaroslav A., Spicak, Julius, Merta, Dusan, Sperl, Jan

“…Heterozygotes for Z or S alleles of alpha-1-antrypsin (AAT) have low serum AAT levels. Our aim was to compare the risk of hepatocellular carcinoma (HCC) in…”
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Mechanical regulation of mitochondrial morphodynamics in cancer cells by extracellular microenvironment by Lunova, Mariia, Jirsa, Milan, Dejneka, Alexandr, Sullivan, Gareth John, Lunov, Oleg

“…•Mitochondria fuse and divide in response to physical cues.•Alterations in mitochondrial dynamics as linked to cancer progression.•Cancer development and…”
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Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells by Lunova, Mariia, Schwarz, Peggy, Nuraldeen, Renwar, Levada, Kateryna, Kuscuoglu, Deniz, Stützle, Michael, Vujić Spasić, Maja, Haybaeck, Johannes, Ruchala, Piotr, Jirsa, Milan, Deschemin, Jean‐Christophe, Vaulont, Sophie, Trautwein, Christian, Strnad, Pavel

“…Iron is both an essential and a potentially toxic element, and its systemic homeostasis is controlled by the iron hormone hepcidin. Hepcidin binds to the…”
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Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells by Uzhytchak, Mariia, Smolková, Barbora, Lunova, Mariia, Jirsa, Milan, Frtús, Adam, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg

“…Iron oxide-based nanoparticles have been repeatedly shown to affect lysosomal-mediated signaling. Recently, nanoparticles have demonstrated an ability to…”
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Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis by Levada, Kateryna, Pshenichnikov, Stanislav, Omelyanchik, Alexander, Rodionova, Valeria, Nikitin, Aleksey, Savchenko, Alexander, Schetinin, Igor, Zhukov, Dmitry, Abakumov, Maxim, Majouga, Alexander, Lunova, Mariia, Jirsa, Milan, Smolková, Barbora, Uzhytchak, Mariia, Dejneka, Alexandr, Lunov, Oleg

“…Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver…”
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Hepatic Tumor Cell Morphology Plasticity under Physical Constraints in 3D Cultures Driven by YAP-mTOR Axis by Frtús, Adam, Smolková, Barbora, Uzhytchak, Mariia, Lunova, Mariia, Jirsa, Milan, Hof, Martin, Jurkiewicz, Piotr, Lozinsky, Vladimir I, Wolfová, Lucie, Petrenko, Yuriy, Kubinová, Šárka, Dejneka, Alexandr, Lunov, Oleg

“…Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo-Yes-associated protein 1 (YAP) pathways are important mediators of…”
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Multifunctional Fe3O4-Au Nanoparticles for the MRI Diagnosis and Potential Treatment of Liver Cancer by Kozenkova, Elena, Levada, Kateryna, Efremova, Maria V., Omelyanchik, Alexander, Nalench, Yulia A., Garanina, Anastasiia S., Pshenichnikov, Stanislav, Zhukov, Dmitry G., Lunov, Oleg, Lunova, Mariia, Kozenkov, Ivan, Innocenti, Claudia, Albino, Martin, Abakumov, Maxim A., Sangregorio, Claudio, Rodionova, Valeria

“…Heterodimeric nanoparticles comprising materials with different functionalities are of great interest for fundamental research and biomedical/industrial…”
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Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules by Wögenstein, Karl L, Szabo, Sandra, Lunova, Mariia, Wiche, Gerhard, Haybaeck, Johannes, Strnad, Pavel, Boor, Peter, Wagner, Martin, Fuchs, Peter

“…Epiplakin, a member of the plakin protein family, is exclusively expressed in epithelial tissues and was shown to bind to keratins. Epiplakin-deficient…”
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Hsp72 overexpression accelerates the recovery from caerulein-induced pancreatitis by Lunova, Mariia, Zizer, Eugen, Kucukoglu, Ozlem, Schwarz, Carolin, Dillmann, Wolfgang H, Wagner, Martin, Strnad, Pavel

“…Heat shock protein (Hsp) 72 is a molecular chaperone which is upregulated in response to a variety of stress situations and has a general cytoprotective…”
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Non-coding keratin variants associate with liver fibrosis progression in patients with hemochromatosis by Strnad, Pavel, Kucukoglu, Ozlem, Lunova, Mariia, Guldiken, Nurdan, Lienau, Tim C, Stickel, Felix, Omary, M Bishr

“…Keratins 8 and 18 (K8/K18) are intermediate filament proteins that protect the liver from various forms of injury. Exonic K8/K18 variants associate with…”
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Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma by Usachov, Valentyn, Nahon, Pierre, Lunova, Mariia, Ziol, Marianne, Rufat, Pierre, Sutton, Angela, Beaugrand, Michel, Strnad, Pavel

“…Keratins 8/18 (K8/K18) are established hepatoprotective proteins and K8/K18 variants predispose to development and adverse outcome of multiple liver disorders…”
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