Search Results - "Lunn, J Simon"

Stem cell technology for neurodegenerative diseases by Lunn, J. Simon, Sakowski, Stacey A., Hur, Junguk, Feldman, Eva L.

“…Over the past 20 years, stem cell technologies have become an increasingly attractive option to investigate and treat neurodegenerative diseases. In the…”
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A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification by Stavridis, Marios P, Lunn, J Simon, Collins, Barry J, Storey, Kate G

“…Neural tissue formation is induced by growth factors that activate networks of signal transduction cascades that ultimately lead to the expression of early…”
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Concise Review: Stem Cell Therapies for Amyotrophic Lateral Sclerosis: Recent Advances and Prospects for the Future by Lunn, J. Simon, Sakowski, Stacey A., Feldman, Eva L.

“…Amyotrophic lateral sclerosis (ALS) is a lethal disease involving the loss of motor neurons. Although the mechanisms responsible for motor neuron degeneration…”
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A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo by Lunn, J. Simon, Fishwick, Katherine J., Halley, Pam A., Storey, Kate G.

“…During early vertebrate development Fibroblast Growth Factor (FGF) signalling is required for multiple activities including specification of mesodermal, neural…”
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Human Cortical Neural Stem Cells Expressing Insulin‐Like Growth Factor‐I: A Novel Cellular Therapy for Alzheimer's Disease by McGinley, Lisa M., Sims, Erika, Lunn, J. Simon, Kashlan, Osama N., Chen, Kevin S., Bruno, Elizabeth S., Pacut, Crystal M., Hazel, Tom, Johe, Karl, Sakowski, Stacey A., Feldman, Eva L.

“…Alzheimer's disease (AD) is the most prevalent age‐related neurodegenerative disorder and a leading cause of dementia. Current treatment fails to modify…”
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Translational stem cell therapy for amyotrophic lateral sclerosis by Boulis, Nicholas M., Federici, Thais, Glass, Jonathan D., Lunn, J. Simon, Sakowski, Stacey A., Feldman, Eva L.

“…The first-in-human phase I trial of stem cell transplantation for amyotrophic lateral sclerosis was approved by the FDA in 2009 and is ongoing. In their…”
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Vascular endothelial growth factor prevents G93A‐SOD1‐induced motor neuron degeneration by Lunn, J. Simon, Sakowski, Stacey A., Kim, Bhumsoo, Rosenberg, Andrew A., Feldman, Eva L.

“…Amyotrophic lateral sclerosis (ALS) is an adult‐onset neurodegenerative disorder characterized by selective loss of motor neurons (MNs). Twenty percent of…”
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Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS by Hefferan, Michael P, Johe, Karl, Hazel, Thomas, Feldman, Eva L, Lunn, J Simon, Marsala, Martin

“…Previous rodent studies employing monotherapy or combined immunosuppressive regimens have demonstrated a variable degree of spinal xenograft survival in…”
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Neuromuscular effects of G93A-SOD1 expression in zebrafish by Sakowski, Stacey A, Lunn, J Simon, Busta, Angela S, Oh, Sang Su, Zamora-Berridi, Grettel, Palmer, Madeline, Rosenberg, Andrew A, Philip, Stephen G, Dowling, James J, Feldman, Eva L

“…Amyotrophic lateral sclerosis (ALS) is a fatal disorder involving the degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are…”
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Specification and maintenance of the spinal cord stem zone by Delfino-Machín, Mariana, Lunn, J Simon, Breitkreuz, Dorette N, Akai, Jun, Storey, Kate G

“…Epiblast cells adjacent to the regressing primitive streak behave as a stem zone that progressively generates the entire spinal cord and also contributes to…”
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Negative Feedback Regulation of FGF Signaling Levels by Pyst1/MKP3 in Chick Embryos by Eblaghie, Maxwell C., Lunn, J.Simon, Dickinson, Robin J., Münsterberg, Andrea E., Sanz-Ezquerro, Juan-Jose, Farrell, Elizabeth R., Mathers, Joanne, Keyse, Stephen M., Storey, Kate, Tickle, Cheryll

“…Background: The importance of endogenous antagonists in intracellular signal transduction pathways is becoming increasingly recognized. There is evidence in…”
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Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors by Lunn, J. Simon, Pacut, Crystal, Stern, Emily, Sakowski, Stacey A, Velkey, J. Matthew, O'Shea, Sue, Feldman, Eva L

“…Abstract Embryonic stem (ES) cells and their derivatives are an important resource for developing novel cellular therapies for disease. Controlling…”
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The pleotrophic effects of insulin-like growth factor-I on human spinal cord neural progenitor cells by Lunn, J Simon, Pacut, Crystal, Backus, Carey, Hong, Yu, Johe, Karl, Hefferan, Michael, Marsala, Martin, Feldman, Eva L

“…Most stem cell therapies involve direct, intraparachymal placement of neural progenitor cells. These cells provide physical support to the endogenous neuronal…”
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Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms by Figueroa-Romero, Claudia, Hur, Junguk, Lunn, J. Simon, Paez-Colasante, Ximena, Bender, Diane E., Yung, Raymond, Sakowski, Stacey A., Feldman, Eva L.

“…Amyotrophic lateral sclerosis is a late-onset and terminal neurodegenerative disease. The majority of cases are sporadic with unknown causes and only a small…”
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Autocrine Production of IGF‐I Increases Stem Cell‐Mediated Neuroprotection by Lunn, J. Simon, Sakowski, Stacey A., McGinley, Lisa M., Pacut, Crystal, Hazel, Thomas G., Johe, Karl, Feldman, Eva L.

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder resulting in motor neuron (MN) loss. There are currently no effective therapies;…”
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Stem cell technology for the study and treatment of motor neuron diseases by Lunn, J Simon, Sakowski, Stacey A, Federici, Thais, Glass, Jonathan D, Boulis, Nicholas M, Feldman, Eva L

“…Amyotrophic lateral sclerosis and spinal muscular atrophy are devastating neurodegenerative diseases that lead to the specific loss of motor neurons. Recently,…”
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Stem cells: comprehensive treatments for amyotrophic lateral sclerosis in conjunction with growth factor delivery by Lunn, J. Simon, Hefferan, Michael P., Marsala, Martin, Feldman, Eva L.

“…Amyotrophic lateral sclerosis (ALS) is characterized by loss of both upper and lower motor neurons. ALS progression is complex and likely due to cellular…”
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A novel approach to study motor neurons from zebrafish embryos and larvae in culture by Sakowski, Stacey A., Lunn, J. Simon, Busta, Angela S., Palmer, Madeline, Dowling, James J., Feldman, Eva L.

“…► Primary neuron cultures from 24 to 96h post-fertilization zebrafish embryos. ► Cultures are obtained from embryos after in vivo motor neuron axon outgrowth…”
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Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos by Smith, Terence Gordon, Karlsson, Maria, Lunn, J. Simon, Eblaghie, Maxwell C., Keenan, Iain D., Farrell, Elizabeth R., Tickle, Cheryll, Storey, Kate G., Keyse, Stephen M.

“…Expression of the gene encoding the MKP-3/Pyst1 protein phosphatase, which inactivates ERK MAPK, is induced by FGF. However, which intracellular signalling…”
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Stem cell therapies for amyotrophic lateral sclerosis: Recent advances and prospects for the future by Lunn, J. Simon, Sakowski, Stacey A., Feldman, Eva L.

“…Amyotrophic lateral sclerosis (ALS) is a lethal disease involving the loss of motor neurons. Although the mechanisms responsible for motor neuron degeneration…”
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