Search Results - "Lung, Raymond W."

Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma by Law, Priscilla T.-Y, Qin, Hao, Ching, Arthur K.-K, Lai, Keng Po, Co, Ngai Na, He, Mian, Lung, Raymond W.-M, Chan, Anthony W.-H, Chan, Ting-Fung, Wong, Nathalie

“…Background & Aims Small non-coding RNAs (ncRNA) are increasingly recognized to play important roles in tumorigenesis. With the advent of deep sequencing,…”
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MicroRNA-223 Is Commonly Repressed in Hepatocellular Carcinoma and Potentiates Expression of Stathmin1 by Wong, Queenie W.–L, Lung, Raymond W.–M, Law, Priscilla T.–Y, Lai, Paul B.–S, Chan, Kathy Y.–Y, To, Ka–Fai, Wong, Nathalie

“…Background & Aims: Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma…”
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Genome‐wide identification of Epstein‐Barr virus–driven promoter methylation profiles of human genes in gastric cancer cells by Zhao, Junhong, Liang, Qiaoyi, Cheung, Kin‐Fai, Kang, Wei, Lung, Raymond W. M., Tong, Joanna H. M., To, Ka Fai, Sung, Joseph J. Y., Yu, Jun

“…BACKGROUND: Aberrant methylation of tumor‐related genes has been reported in Epstein‐Barr virus (EBV)‐associated gastric cancers. This study sought to profile…”
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Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis by WEI KANG, TONG, Joanna H. M, SUNG, Joseph J. Y, TO, Ka-Fai, CHAN, Anthony W. H, LEE, Tin-Lap, LUNG, Raymond W. M, LEUNG, Patrick P. S, SO, Ken K. Y, KAICHUN WU, DAIMING FAN, JUN YU

“…Yes-associated protein 1 (YAP1) is a multifunctional protein that can interact with different transcription factors to activate gene expression. The role of…”
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Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming by Xiong, Lei, Wu, Feng, Wu, Qiong, Xu, Liangliang, Cheung, Otto K., Kang, Wei, Mok, Myth T., Szeto, Lemuel L. M., Lun, Cheuk-Yin, Lung, Raymond W., Zhang, Jinglin, Yu, Ken H., Lee, Sau-Dan, Huang, Guangcun, Wang, Chiou-Miin, Liu, Joseph, Yu, Zhuo, Yu, Dae-Yeul, Chou, Jian-Liang, Huang, Wan-Hong, Feng, Bo, Cheung, Yue-Sun, Lai, Paul B., Tan, Patrick, Wong, Nathalie, Chan, Michael W., Huang, Tim H., Yip, Kevin Y., Cheng, Alfred S., To, Ka-Fai

“…Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers…”
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Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer by Kang, Wei, Tong, Joanna H M, Chan, Anthony W H, Lung, Raymond W M, Chau, Shuk Ling, Wong, Queenie W L, Wong, Nathalie, Yu, Jun, Cheng, Alfred S L, To, Ka Fai

“…Stathmin1 (STMN1) is a candidate oncoprotein and prognosis marker in several kinds of cancers. This study was aimed to analyze its expression and biological…”
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Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma by Kang, Wei, Tong, Joanna H M, Lung, Raymond W M, Dong, Yujuan, Zhao, Junhong, Liang, Qiaoyi, Zhang, Li, Pan, Yi, Yang, Weiqin, Pang, Jesse C S, Cheng, Alfred S L, Yu, Jun, To, Ka Fai

“…MicroRNAs (miRNAs) have been reported to play an important role in tumorigenesis. In this study, the role of miR-15a and miR-16-1 in gastric adenocarcinoma…”
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Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression by Lau, Chi-Chiu, Sun, Tingting, Ching, Arthur K.K., He, Mian, Li, Jing-Woei, Wong, Alissa M., Co, Ngai Na, Chan, Anthony W.H., Li, Pik-Shan, Lung, Raymond W.M., Tong, Joanna H.M., Lai, Paul B.S., Chan, Henry L.Y., To, Ka-Fai, Chan, Ting-Fung, Wong, Nathalie

“…The mutagenic effect of hepatitis B (HBV) integration in predisposing risk to hepatocellular carcinoma (HCC) remains elusive. In this study, we performed…”
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miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis by Kang, Wei, Huang, Tingting, Zhou, Yuhang, Zhang, Jinglin, Lung, Raymond W. M., Tong, Joanna H. M., Chan, Anthony W. H., Zhang, Bin, Wong, Chi Chun, Wu, Feng, Dong, Yujuan, Wang, Shiyan, Yang, Weiqin, Pan, Yi, Chak, Wing Po, Cheung, Alvin H. K., Pang, Jesse C. S., Yu, Jun, Cheng, Alfred S. L., To, Ka Fai

“…miR-375 is a tumor-suppressive microRNA (miRNA) in gastric cancer (GC). However, its molecular mechanism remains unclear. The aim of this study is to…”
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Detection of ALK rearrangement by immunohistochemistry in lung adenocarcinoma and the identification of a novel EML4-ALK variant by To, Ka-Fai, Tong, Joanna H M, Yeung, King S F, Lung, Raymond W M, Law, Peggy P Y, Chau, Shuk Ling, Kang, Wei, Tong, Carol Y K, Chow, Chit, Chan, Anthony W H, Leung, Linda K S, Mok, Tony S K

“…The echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) fusion gene has been identified as a potent oncogenic driver in…”
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EBV‐encoded miRNAs target ATM‐mediated response in nasopharyngeal carcinoma by Lung, Raymond W‐M, Hau, Pok‐Man, Yu, Ken H‐O, Yip, Kevin Y, Tong, Joanna H‐M, Chak, Wing‐Po, Chan, Anthony W‐H, Lam, Ka‐Hei, Lo, Angela Kwok‐Fung, Tin, Edith K‐Y, Chau, Shuk‐Ling, Pang, Jesse C‐S, Kwan, Johnny S‐H, Busson, Pierre, Young, Lawrence S, Yap, Lee‐Fah, Tsao, Sai‐Wah, To, Ka‐Fai, Lo, Kwok‐Wai

“…Nasopharyngeal carcinoma (NPC) is a highly invasive epithelial malignancy that is prevalent in southern China and Southeast Asia. It is consistently associated…”
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let-7b/g silencing activates AKT signaling to promote gastric carcinogenesis by Kang, Wei, Tong, Joanna H M, Lung, Raymond W M, Dong, Yujuan, Yang, Weiqin, Pan, Yi, Lau, Kin Mang, Yu, Jun, Cheng, Alfred Sl, To, Ka Fai

“…Aberrant AKT activation contributes to gastric cancer cell survival and chemotherapy resistance, however its regulation is poorly understood. microRNAs have…”
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Receptor tyrosine kinase fusions act as a significant alternative driver of the serrated pathway in colorectal cancer development by Chan, Anthony W‐H, Pan, Yi, Tong, Joanna H‐M, Lung, Raymond W‐M, Kwan, Johnny S‐H, Chow, Chit, Tin, Edith K‐Y, Chung, Lau‐Ying, Li, Hui, Wong, Shela S‐Y, Chau, Shuk‐Ling, Chan, Yuk Yu, Mak, Tony W‐C, Ng, Simon Siu‐Man, To, Ka‐Fai

“…Serrated polyps are a clinically and molecularly heterogeneous group of lesions that can contribute to the development of colorectal cancers (CRCs). However,…”
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Characterization of rare transforming KRAS mutations in sporadic colorectal cancer by Tong, Joanna HM, Lung, Raymond WM, Sin, Frankie MC, Law, Peggy PY, Kang, Wei, Chan, Anthony WH, Ma, Brigette BY, Mak, Tony WC, Ng, Simon SM, To, Ka Fai

“…KRAS mutational status has been shown to be a predictive biomarker of resistance to anti-EGFR monoclonal antibody (mAb) therapy in patients with metastatic…”
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EXOSC4 functions as a potential oncogene in development and progression of colorectal cancer by Pan, Yi, Tong, Joanna H. M., Kang, Wei, Lung, Raymond W. M., Chak, Wing Po, Chung, Lau Ying, Wu, Feng, Li, Hui, Yu, Jun, Chan, Anthony W. H., To, Ka Fai

“…Colorectal cancer (CRC) is a heterogeneous disease with complex mechanisms of pathogenesis. Classification systems have been proposed based on molecular…”
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Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma by Tong, Joanna H, Ng, David C, Chau, Shuk L, So, Ken K, Leung, Patrick P, Lee, Tin L, Lung, Raymond W, Chan, Michael W, Chan, Anthony W, Lo, Kwok W, To, Ka F

“…Human disabled-2 (DAB2), is a multi-function signalling molecule that it is frequently down-regulated in human cancers. We aimed to investigate the possible…”
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The molecular classification of cancer‐associated fibroblasts on a pan‐cancer single‐cell transcriptional atlas by Chen, Bonan, Chan, Wai Nok, Xie, Fuda, Mui, Chun Wai, Liu, Xiaoli, Cheung, Alvin H. K., Lung, Raymond W. M., Chow, Chit, Zhang, Zhenhua, Fang, Canbin, Yu, Peiyao, Shi, Shihua, Zhou, Shikun, Chen, Guoming, Wang, Zhangding, Wang, Shouyu, Ding, Xiaofan, Huang, Bing, Liang, Li, Dong, Yujuan, Wong, Chi Chun, Wu, William K. K., Cheng, Alfred S. L., Wong, Nathalie, Yu, Jun, Lo, Kwok Wai, Tse, Gary M. K., Kang, Wei, To, Ka Fai

“…Background Cancer‐associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro‐tumourigenic…”
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Expression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1 by Lee, Maggie Y.T., Zhou, Yuanxiang, Lung, Raymond W.M., Chye, Mee-Len, Yip, Wing-Kin, Zee, Sze-Yong, Lam, Eric

“…Epstein‐Barr virus (EBV) infects nearly 90% of adults worldwide and is the pathogenic source of a broad spectrum of malignancies originating from lymphoid and…”
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Assessment of programmed cell death ligand-1 expression by 4 diagnostic assays and its clinicopathological correlation in a large cohort of surgical resected non-small cell lung carcinoma by Chan, Anthony W. H., Tong, Joanna H. M., Kwan, Johnny S. H., Chow, Chit, Chung, Lau Y., Chau, Shuk L., Lung, Raymond W. M., Ng, Calvin S. H., Wan, Innes Y. P., Mok, Tony S. K., To, Ka F.

“…Immune checkpoint blockade targeting the PD-1/PD-L1 axis has recently demonstrated efficacy and promise in cancer treatment. Appropriate biomarker selection is…”
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Integrative Identification of Epstein–Barr Virus–Associated Mutations and Epigenetic Alterations in Gastric Cancer by Liang, Qiaoyi, Yao, Xiaotian, Tang, Senwei, Zhang, Jingwan, Yau, Tung On, Li, Xiaoxing, Tang, Ceen-Ming, Kang, Wei, Lung, Raymond W.M, Li, Jing Woei, Chan, Ting Fung, Xing, Rui, Lu, Youyong, Lo, Kwok Wai, Wong, Nathalie, To, Ka Fai, Yu, Chang, Chan, Francis K.L, Sung, Joseph J.Y, Yu, Jun

“…Background & Aims The mechanisms by which Epstein–Barr virus (EBV) contributes to the development of gastric cancer are unclear. We investigated EBV-associated…”
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