Search Results - "Lundy, Kristin M"

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog by Sakya, Subas M., Lundy DeMello, Kristin M., Minich, Martha L., Rast, Bryson, Shavnya, Andrei, Rafka, Robert J., Koss, David A., Cheng, Hengmiao, Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Lund, Lisa A., Denis, Suzanne St, Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-lyl]-5-methanesulfonyl (SO 2Me)/5-sulfamoyl (SO 2NH…”
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Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents:  In Vitro and in Vivo Potency against Pasteurella multocida by McFarland, James W, Berger, Cynthia M, Froshauer, Susan A, Hayashi, Shigeru F, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Kamicker, Barbara J, Lipinski, Christopher A, Lundy, Kristin M, Reese, Catherine P, Vu, Chi B

“…Quantitative structure−activity relationships have been found among macrolide antibacterial agents in their potencies against the bacterial pathogen…”
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In vitro microbiological characterization of a novel azalide, two triamilides and an azalide ketal against bovine and porcine respiratory pathogens by Norcia, Laura J L, Silvia, Annette M, Santoro, Sheryl L, Retsema, Jim, Letavic, Michael A, Bronk, Brian S, Lundy, Kristin M, Yang, Bingwei, Evans, Nigel A, Hayashi, Shigeru F

“…Several novel 15-membered-ring macrolide agents (azalide 1, triamilides 2 and 3, and the azalide 3,6-ketal 4) were identified as potential antibacterial agents…”
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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors by Cheng, Hengmiao, Lundy DeMello, Kristin M., Li, Jin, Sakya, Subas M., Ando, Kazuo, Kawamura, K., Kato, Tomoki, Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Stevens, Rod, Lund, Lisa A., Mann, Donald W., Kilroy, Carolyn, Haven, Michelle L., Nimz, Erik L., Dutra, Jason K., Li, Chao, Minich, Martha L., Kolosko, Nicole L., Petras, Carol, Silvia, Annette M., Seibel, Scott B.

“…The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure–activity relationship (SAR)…”
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Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs by Ricketts, A P, Lundy, K M, Seibel, S B

“…To evaluate the activity of carprofen and other nonsteroidal anti-inflammatory drugs (NSAID) against isozymes of canine cyclooxygenases (COX1 and COX2)…”
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Synthesis of diphthamide: the target of diphtheria toxin catalyzed ADP-ribosylation in protein synthesis elongation factor 2 by Evans, David A, Lundy, Kristin M

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Azalide 3,6-Ketals: antibacterial activity and structure–Activity relationships of aryl and hetero aryl substituted analogues by Sakya, Subas M, Bertinato, Peter, Pratt, Bryan, Suarez-Contreras, Melani, Lundy, Kristin M, Minich, Martha L, Cheng, Hengmiao, Ziegler, Carl B, Kamicker, Barbara J, Hayashi, Shigeru F, Santoro, Sheryl L, George, David M, Bertsche, Camilla D

“…Aryl and hetero aryl substituted 3,6-ketals of 15-membered azalide analogues were synthesized and were found to have potent in vitro antibacterial activity…”
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Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent gram-positive and gram-negative antibacterial agents by Cheng, Hengmiao, Dirlam, John P., Ziegler, Carl B., Lundy, Kristin M., Hayashi, Shigeru F., Kamicker, Barbara J., Dutra, Jason K., Daniel, Kirsten L., Santoro, Sheryl L., George, David M., Bertsche, Camilla D., Sakya, Subas M., Suarez-Contreras, Melani

“…3,6-Ketals of 15-membered azalide pseudoaglycones are a novel series of macrolide antibiotics. The aromatic derivatives of the azalide 3,6-ketals demonstrated…”
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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure–activity relationship studies of 5-alkylethers and 5-thioethers by Sakya, Subas M., Cheng, Hengmiao, Lundy DeMello, Kristin M., Shavnya, Andrei, Minich, Martha L., Rast, Bryson, Dutra, Jason, Li, Chao, Rafka, Robert J., Koss, David A., Li, Jin, Jaynes, Burton H., Ziegler, Carl B., Mann, Donald W., Petras, Carol F., Seibel, Scott B., Silvia, Annette M., George, David M., Hickman, Anne, Haven, Michelle L., Lynch, Michael P.

“…Structure–activity relationship (SAR) studies of novel 2-[3-trifluoromethyl-5-alkyl(thio)ether pyrazo-1-yl]-5-methanesulfonyl pyridine derivatives for canine…”
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Repromicin Derivatives with Potent Antibacterial Activity against Pasteurella multocida by McFarland, James W, Hecker, Scott J, Jaynes, Burton H, Jefson, Martin R, Lundy, Kristin M, Vu, Chi B, Glazer, Edward A, Froshauer, Susan A, Hayashi, Shigeru F, Kamicker, Barbara J, Reese, Catherine P, Olson, Julie A

“…Reductive amination of repromicin with polyfunctional amines has led to new macrolide antibacterial agents, some of which are highly potent against the…”
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Polar substituent effects in the bicyclo[2.2.2]octane ring system: polarography of 4-substituted bicyclo[2.2.2]oct-1-yl iodides by Adcock, William, Kok, Gaik B, Iyer, V. Sankar, Peters, Dennis G, Lundy, Kristin M, Kitching, William

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine by Li, Jin, DeMello, Kristin M.Lundy, Cheng, Henry, Sakya, Subas M., Bronk, Brian S., Rafka, Robert J., Jaynes, Burton H., Ziegler, Carl B., Kilroy, Carolyn, Mann, Donald W., Nimz, Eric L., Lynch, Michael P., Haven, Michelle L., Kolosko, Nicole L., Minich, Martha L., Li, Chao, Dutra, Jason K., Rast, Bryson, Crosson, Rhonda M., Morton, Barry J., Kirk, Glen W., Callaghan, Kathleen M., Koss, David A., Shavnya, Andrei, Lund, Lisa A., Seibel, Scott B., Petras, Carol F., Silvia, Annette

“…Structure–activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes…”
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