Search Results - "Lundegaard, Pia R"

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation by Ahlberg, Gustav, Refsgaard, Lena, Lundegaard, Pia R., Andreasen, Laura, Ranthe, Mattis F., Linscheid, Nora, Nielsen, Jonas B., Melbye, Mads, Haunsø, Stig, Sajadieh, Ahmad, Camp, Lu, Olesen, Søren-Peter, Rasmussen, Simon, Lundby, Alicia, Ellinor, Patrick T., Holst, Anders G., Svendsen, Jesper H., Olesen, Morten S.

“…A family history of atrial fibrillation constitutes a substantial risk of developing the disease, however, the pathogenesis of this complex disease is poorly…”
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Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics by Unterweger, Iris. A, Klepstad, Julie, Hannezo, Edouard, Lundegaard, Pia R, Trusina, Ala, Ober, Elke A

“…To meet the physiological demands of the body, organs need to establish a functional tissue architecture and adequate size as the embryo develops to adulthood…”
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Quantitative proteome comparison of human hearts with those of model organisms by Linscheid, Nora, Santos, Alberto, Poulsen, Pi Camilla, Mills, Robert W, Calloe, Kirstine, Leurs, Ulrike, Ye, Johan Z, Stolte, Christian, Thomsen, Morten B, Bentzen, Bo H, Lundegaard, Pia R, Olesen, Morten S, Jensen, Lars J, Olsen, Jesper V, Lundby, Alicia

“…Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from…”
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Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish by Sokol, Anna M, Uszczynska-Ratajczak, Barbara, Collins, Michelle M, Bazala, Michal, Topf, Ulrike, Lundegaard, Pia R, Sugunan, Sreedevi, Guenther, Stefan, Kuenne, Carsten, Graumann, Johannes, Chan, Sherine S L, Stainier, Didier Y R, Chacinska, Agnieszka

“…Development and function of tissues and organs are powered by the activity of mitochondria. In humans, inherited genetic mutations that lead to progressive…”
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Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish by Sokol, Anna M, Uszczynska-Ratajczak, Barbara, Collins, Michelle M, Bazala, Michal, Topf, Ulrike, Lundegaard, Pia R, Sugunan, Sreedevi, Guenther, Stefan, Kuenne, Carsten, Graumann, Johannes, Chan, Sherine S L, Stainier, Didier Y R, Chacinska, Agnieszka

“…[This corrects the article DOI: 10.1371/journal.pgen.1007743.]…”
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Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice by Ollinger, Rupert, Childs, Andrew J, Burgess, Hannah M, Speed, Robert M, Lundegaard, Pia R, Reynolds, Nicola, Gray, Nicola K, Cooke, Howard J, Adams, Ian R

“…As genetic information is transmitted through successive generations, it passes between pluripotent cells in the early embryo and germ cells in the developing…”
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Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone by Jepps, Thomas A., Carr, Georgina, Lundegaard, Pia R., Olesen, Søren‐Peter, Greenwood, Iain A.

“…Key points KCNE4 alters the biophysical properties and cellular localization of voltage‐gated potassium channel Kv7.4. KCNE4 is expressed in a variety of…”
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Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle by Lindman, Johanna, Khammy, Makhala M, Lundegaard, Pia R, Aalkjær, Christian, Jepps, Thomas A

“…Microtubules can regulate GPCR (G protein–coupled receptor) signaling in various cell types. In vascular smooth muscle, activation of the β-adrenoceptor leads…”
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Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model by Collins, Michelle M., Ahlberg, Gustav, Hansen, Camilla Vestergaard, Guenther, Stefan, Marín-Juez, Rubén, Sokol, Anna M., El-Sammak, Hadil, Piesker, Janett, Hellsten, Ylva, Olesen, Morten S., Stainier, Didier Y. R., Lundegaard, Pia R.

“…Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. The major AF susceptibility locus 4q25 establishes long-range interactions with the…”
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LiverZap: a chemoptogenetic tool for global and locally restricted hepatocyte ablation to study cellular behaviours in liver regeneration by Ambrosio, Elizabeth M G, Bailey, Charlotte S L, Unterweger, Iris A, Christensen, Jens B, Bruchez, Marcel P, Lundegaard, Pia R, Ober, Elke A

“…The liver restores its mass and architecture after injury. Yet, investigating morphogenetic cell behaviours and signals that repair tissue architecture at high…”
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Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish by Bensimon-Brito, Anabela, Boezio, Giulia L M, Cardeira-da-Silva, João, Wietelmann, Astrid, Ramkumar, Srinath, Lundegaard, Pia R, Helker, Christian S M, Ramadass, Radhan, Piesker, Janett, Nauerth, Arno, Mueller, Clemens, Stainier, Didier Y R

“…Abstract Aims Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with…”
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Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis by Andreasen, Laura, Bertelsen, Litten, Ghouse, Jonas, Lundegaard, Pia R., Ahlberg, Gustav, Refsgaard, Lena, Rasmussen, Torsten B., Eiskjær, Hans, Haunsø, Stig, Vejlstrup, Niels, Svendsen, Jesper H., Olesen, Morten S.

“…Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture…”
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Genetic Variants Close to TTN , NKX2-5 , and MYH6 Associate With AVNRT by Andreasen, Laura, Ahlberg, Gustav, Ægisdottir, Hildur M., Sveinbjörnsson, Gardar, Lundegaard, Pia R., Hartmann, Jacob P., Paludan-Müller, Christian, Hadji-Turdeghal, Katra, Ghouse, Jonas, Pehrson, Steen, Jensen, Henrik K., Riahi, Sam, Hansen, Jim, Sandgaard, Niels, Sørensen, Erik, Banasik, Karina, Sækmose, Susanne G., Bruun, Mie T., Hjalgrim, Henrik, Erikstrup, Christian, Pedersen, Ole B., Wittig, Michael, Haunsø, Stig, Ostrowski, Sisse R., Franke, Andre, Brunak, Søren, Kanters, Jørgen K., Ellervik, Christina, Bundgaard, Henning, Ullum, Henrik, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Holm, Hilma, Arnar, David O., Stefansson, Kari, Svendsen, Jesper H., Olesen, Morten S.

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Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation by Vad, Oliver B., Angeli, Elisavet, Liss, Martin, Ahlberg, Gustav, Andreasen, Laura, Christophersen, Ingrid E., Hansen, Camilla C., Møller, Sophie, Hellsten, Ylva, Haunsoe, Stig, Tveit, Arnljot, Svendsen, Jesper H., Gotthardt, Michael, Lundegaard, Pia R., Olesen, Morten S.

“…[Display omitted] •Loss of function variants in the key cardiac splicing regulator RBM20 were associated with atrial fibrillation in 2 independent…”
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Small molecule screening identifies targetable zebrafish pigmentation pathways by Colanesi, Sarah, Taylor, Kerrie L., Temperley, Nicholas D., Lundegaard, Pia R., Liu, Dong, North, Trista E., Ishizaki, Hironori, Kelsh, Robert N., Patton, E. Elizabeth

“…Summary Small molecules complement genetic mutants and can be used to probe pigment cell biology by inhibiting specific proteins or pathways. Here, we present…”
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MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish by Lundegaard, Pia R., Anastasaki, Corina, Grant, Nicola J., Sillito, Rowland R., Zich, Judith, Zeng, Zhiqiang, Paranthaman, Karthika, Larsen, Anders Peter, Armstrong, J. Douglas, Porteous, David J., Patton, E. Elizabeth

“…Altered phosphodiesterase (PDE)-cyclic AMP (cAMP) activity is frequently associated with anxiety disorders, but current therapies act by reducing neuronal…”
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Genetic Variants Close to TTN, NKX2-5, and MYH6 Associate With AVNRT by Andreasen, Laura, Ahlberg, Gustav, Ægisdóttir, Hildur M., Sveinbjörnsson, Gardar, Lundegaard, Pia R., Hartmann, Jacob P., Paludan-Müller, Christian, Hadji-Turdeghal, Katra, Ghouse, Jonas, Pehrson, Steen, Jensen, Henrik K., Riahi, Sam, Hansen, Jim, Sandgaard, Niels, Sørensen, Erik, Banasik, Karina, Sækmose, Susanne G., Bruun, Mie T., Hjalgrim, Henrik, Erikstrup, Christian, Pedersen, Ole B., Wittig, Michael, Haunsø, Stig, Ostrowski, Sisse R., Genomic Consortium, DBDS, Franke, Andre, Brunak, Søren, Kanters, Jørgen K., Ellervik, Christina, Bundgaard, Henning, Ullum, Henrik, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Holm, Hilma, Arnar, David O., Stefansson, Kari, Svendsen, Jesper H., Olesen, Morten S.

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Deletion of the Pluripotency-Associated Tex19.1 Gene Causes Activation of Endogenous Retroviruses and Defective Spermatogenesis in Mice: e1000199 by Öllinger, Rupert, Childs, Andrew J, Burgess, Hannah M, Speed, Robert M, Lundegaard, Pia R, Reynolds, Nicola, Gray, Nicola K, Cooke, Howard J, Adams, Ian R

“…As genetic information is transmitted through successive generations, it passes between pluripotent cells in the early embryo and germ cells in the developing…”
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