Search Results - "Lundeen, Scott G."

The discovery of a potent orally efficacious indole androgen receptor antagonist through in vivo screening by Lanter, James C., Fiordeliso, James J., Jiang, Weiqin, Allan, George F., Lai, Muh-Tsann, Linton, Olivia, Hahn, Do Won, Lundeen, Scott G., Sui, Zhihua

“…A series of novel 2-(1H-indol-2-yl)-propan-2-ols have been designed, synthesized, and screened for their ability to inhibit testosterone-induced prostate…”
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Discovery of indole-containing tetracycles as a new scaffold for androgen receptor ligands by Zhang, Xuqing, Li, Xiaojie, Allan, George F., Musto, Amy, Lundeen, Scott G., Sui, Zhihua

“…A novel series of tetracyclic indoles ( I) have been designed, synthesized and evaluated as androgen receptor (AR) ligands. Studies of structure–activity…”
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Characterization of the Ovariectomized Rat Model for the Evaluation of Estrogen Effects on Plasma Cholesterol Levels by Lundeen, Scott G, Carver, Jeffrey M, McKean, Mar-Lee, Winneker, Richard C

“…Estrogens protect against cardiovascular disease in women through effects on the vascular wall and liver. Here we further characterize the rat as a model for…”
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Synthesis and SAR of tetracyclic pyrroloquinolones as phosphodiesterase 5 inhibitors by Jiang, Weiqin, Alford, Vernon C, Qiu, Yuhong, Bhattacharjee, Sheela, John, T.Matthew, Haynes-Johnson, Donna, Kraft, Patricia J, Lundeen, Scott G, Sui, Zhihua

“…The synthesis of the fused tetracyclic pyrroloquinolones 9a– i in four steps is described. The PDE5 inhibitory activities of these compounds, their…”
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Design, Synthesis, and in Vivo SAR of a Novel Series of Pyrazolines as Potent Selective Androgen Receptor Modulators by Zhang, Xuqing, Li, Xiaojie, Allan, George F, Sbriscia, Tifanie, Linton, Olivia, Lundeen, Scott G, Sui, Zhihua

“…A novel series of pyrazolines 2 have been designed, synthesized, and evaluated by in vivo screening as tissue-selective androgen receptor modulators (SARMs)…”
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Pharmacological characterization of an imidazolopyrazole as novel selective androgen receptor modulator by Zhang, Xuqing, Allan, George F., Tannenbaum, Pamela, Sbriscia, Tifanie, Linton, Olivia, Lai, Muh-Tsann, Haynes-Johnson, Donna, Bhattacharjee, Sheela, Lundeen, Scott G., Sui, Zhihua

“…► SARMs have anabolic activity on muscle over prostate. ► The imidazolopyrazole was discovered as SARM agonist with mixed agonistic and antagonistic activities…”
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Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence by Zhang, Xuqing, Qiu, Yuhong, Li, Xiaojie, Bhattacharjee, Sheela, Woods, Morgan, Kraft, Patricia, Lundeen, Scott G, Sui, Zhihua

“…A novel series of benzopyran derivatives were synthesized and evaluated as K(ATP) channel openers. Structure-activity relationships were investigated around…”
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Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators by Zhang, Xuqing, Allan, George F., Sbriscia, Tifanie, Linton, Olivia, Lundeen, Scott G., Sui, Zhihua

“…A novel series of hydantoin derivatives were identified by in vivo studies as tissue selective androgen receptor modulators. SAR around this series revealed…”
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Synthesis of potent and tissue-selective androgen receptor modulators (SARMs): 2-(2,2,2)-Trifluoroethyl-benzimidazole scaffold by Ng, Raymond A., Lanter, James C., Alford, Vernon C., Allan, George F., Sbriscia, Tifanie, Lundeen, Scott G., Sui, Zhihua

“…The synthesis and in vivo SAR of 2-(2,2,2)-trifluoroethyl-benzimidazoles are described. Prostate antagonism and/or levator ani agonism can be modulated by…”
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Emerging role of genomics in endometriosis research by Taylor, Robert N, Lundeen, Scott G, Giudice, Linda C

“…Rapidly evolving methods in genomics and proteomics research already are changing the nature of biomedical investigation. In this report we briefly review some…”
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Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators by Zhang, Xuqing, Li, Xiaojie, Allan, George F., Sbriscia, Tifanie, Linton, Olivia, Lundeen, Scott G., Sui, Zhihua

“…A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy. A novel…”
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Discovery and structure-activity relationships of a novel series of benzopyran-based KATP openers for urge urinary incontinence by XUQING ZHANG, YUHONG QIU, XIAOJIE LI, BHATTACHARJEE, Sheela, WOODS, Morgan, KRAFT, Patricia, LUNDEEN, Scott G, ZHIHUA SUI

“…A novel series of benzopyran derivatives were synthesized and evaluated as KATP channel openers. Structure-activity relationships were investigated around…”
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A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats by Allan, George F, Tannenbaum, Pamela, Sbriscia, Tifanie, Linton, Olivia, Lai, Muh-Tsann, Haynes-Johnson, Donna, Bhattacharjee, Sheela, Zhang, Xuqing, Sui, Zhihua, Lundeen, Scott G

“…Androgen receptor (AR) ligands with tissue selectivity (selective androgen receptor modulators, or SARMs) have potential for treating muscle wasting,…”
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Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives by Ng, Raymond A., Guan, Jihua, Alford, Vernon C., Lanter, James C., Allan, George F., Sbriscia, Tifanie, Linton, Olivia, Lundeen, Scott G., Sui, Zhihua

“…The synthesis and in vivo SAR of 5,6-dichloro-benzimidazole derivatives as novel selective androgen receptor antagonists are described. During screening of…”
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2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists by Ng, Raymond A., Guan, Jihua, Alford, Vernon C., Lanter, James C., Allan, George F., Sbriscia, Tifanie, Lundeen, Scott G., Sui, Zhihua

“…The synthesis and in vivo SAR of N-benzyl, N-aceto, and N-ethylene ether derivatives of 2-(2,2,2-trifluoroethyl)-5,6-dichloro-benzimidazole as novel androgen…”
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Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs with dissociated antiprogesterone activities by Jin, Chunyang, Manikumar, G., Kepler, John A., Edgar Cook, C., Allan, George F., Kiddoe, Margaret, Bhattacharjee, Sheela, Linton, Olivia, Lundeen, Scott G., Sui, Zhihua

“…A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs have been synthesized and evaluated for their antiprogesterone and…”
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Cell type-specific bidirectional regulation of the glucocorticoid-induced leucine zipper (GILZ) gene by estrogen by Tynan, Sharon H., Lundeen, Scott G., Allan, George F.

“…Estrogen has numerous beneficial physiological actions; however, by acting as a mitogen, it plays a significant role in the induction and maintenance of breast…”
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Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone by Lundeen, Scott G, Zhang, Zhiming, Zhu, Yuan, Carver, Jeffrey M, Winneker, Richard C

“…Progestins have a wide variety of activities in female reproduction. There are also pharmacological applications for progestins, including hormone replacement…”
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Altered activities of cyclic nucleotide phosphodiesterases and soluble guanylyl cyclase in cultured RFL-6 cells by Kraft, Patricia J, Haynes-Johnson, Donna, Bhattacharjee, Sheela, Lundeen, Scott G, Qiu, Yuhong

“…We utilized rat fetal lung fibroblasts (RFL-6) to evaluate our PDE5 inhibitors at cellular level and observed a decrease in cGMP accumulation induced by sodium…”
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In vitro characterization of trimegestone: a new potent and selective progestin by Zhang, Zhiming, Lundeen, Scott G, Zhu, Yuan, Carver, Jeffrey M, Winneker, Richard C

“…Trimegestone (TMG) is a novel 19-norpregnane progestin under development for hormone replacement therapy and oral contraception. The objective of the current…”
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