Search Results - "Lundberg, Carina Vingsbo"

ENABLE: an engine for European antibacterial drug discovery and development by Olliver, Marie, Griestop, Laura, Hughes, Diarmaid, Belfrage, Anna Karin, Gising, Johan, Baranczewski, Pawel, Vingsbo Lundberg, Carina, Karlén, Anders

“…ENABLE is an antibacterial drug discovery and development consortium formed as a public–private partnership in 2014 as part of the Innovative Medicines…”
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Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages by Ba, Xiaoliang, Raisen, Claire L., Restif, Olivier, Cavaco, Lina Maria, Vingsbo Lundberg, Carina, Lee, Jean Y. H., Howden, Benjamin P., Bartels, Mette D., Strommenger, Birgit, Harrison, Ewan M., Larsen, Anders Rhod, Holmes, Mark A., Larsen, Jesper

“…Global spread of multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages underscores the need for new therapeutic strategies. Here we show…”
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Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model by Vingsbo Lundberg, Carina, Frimodt-Møller, Niels

“…Abstract Meticillin-resistant Staphylococcus aureus (MRSA) is a rapidly spreading pathogen associated predominantly with skin infections. The lack of clinical…”
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Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection by Agger, Else Marie, Cassidy, Joseph P., Brady, Joseph, Korsholm, Karen S., Vingsbo‐Lundberg, Carina, Andersen, Peter

“…Summary It is known that protection against tuberculosis is mediated primarily by T helper type 1 (Th1) cells but the influence of the Th1/Th2 balance of a…”
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Difference in TB10.4 T-cell epitope recognition following immunization with recombinant TB10.4, BCG or infection with Mycobacterium tuberculosis by Billeskov, Rolf, Grandal, Michael V, Poulsen, Christian, Christensen, Jan P, Winther, Nathalie, Vingsbo-Lundberg, Carina, Hoang, Truc T.K.T, van Deurs, Bo, Song, Young-Hwa, Aagaard, Claus, Andersen, Peter, Dietrich, Jes

“…Most novel vaccines against infectious diseases are based on recombinant Ag; however, only few studies have compared Ag-specific immune responses induced by…”
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An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria by Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus, Cooper, Matthew A.

“…ABSTRACT Peptide antibiotics are an abundant and synthetically tractable source of molecular diversity, but they are often cationic and can be cytotoxic,…”
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Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site by Pantel, Lucile, Florin, Tanja, Dobosz-Bartoszek, Malgorzata, Racine, Emilie, Sarciaux, Matthieu, Serri, Marine, Houard, Jessica, Campagne, Jean-Marc, de Figueiredo, Renata Marcia, Midrier, Camille, Gaudriault, Sophie, Givaudan, Alain, Lanois, Anne, Forst, Steve, Aumelas, André, Cotteaux-Lautard, Christelle, Bolla, Jean-Michel, Vingsbo Lundberg, Carina, Huseby, Douglas L., Hughes, Diarmaid, Villain-Guillot, Philippe, Mankin, Alexander S., Polikanov, Yury S., Gualtieri, Maxime

“…Growing resistance of pathogenic bacteria and shortage of antibiotic discovery platforms challenge the use of antibiotics in the clinic. This threat calls for…”
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Translational in vitro and in vivo PKPD modelling for apramycin against Gram-negative lung pathogens to facilitate prediction of human efficacious dose in pneumonia by Aranzana-Climent, Vincent, Hughes, Diarmaid, Cao, Sha, Tomczak, Magdalena, Urbas, Malgorzata, Zabicka, Dorota, Lundberg, Carina Vingsbo, Hansen, Jon, Lindberg, Johan, Hobbie, Sven N., Friberg, Lena E.

“…New drugs and methods to efficiently fight carbapenem-resistant Gram-negative pathogens are sorely needed. In this study we characterized the preclinical…”
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In Vitro and In Vivo Characterization of NOSO-502, a Novel Inhibitor of Bacterial Translation by Racine, Emilie, Nordmann, Patrice, Pantel, Lucile, Sarciaux, Matthieu, Serri, Marine, Houard, Jessica, Villain-Guillot, Philippe, Demords, Anthony, Vingsbo Lundberg, Carina, Gualtieri, Maxime

“…Antibacterial activity screening of a collection of strains led to the discovery of the odilorhabdins, a new antibiotic class with broad-spectrum activity…”
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Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models by Frimodt-Møller, Niels, Hansen, Jon U., Plattner, Michel, Huseby, Douglas L., Radmer Almind, Stine, Haldimann, Klara, Gysin, Marina, Petersson, Anna, Ercan, Onur, Ganz, Lea, Hughes, Diarmaid, Vingsbo Lundberg, Carina, Hobbie, Sven N.

“…•Aminoglycoside resistance is abundant in Enterobacterales.•Apramycin covers 99% of more than 15 000 blood culture isolates.•Apramycin has potent in vivo…”
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Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria by Huseby, Douglas L, Cao, Sha, Zamaratski, Edouard, Sooriyaarachchi, Sanjeewani, Ahmad, Shabbir, Bergfors, Terese, Krasnova, Laura, Pelss, Juris, Ikaunieks, Martins, Loza, Einars, Katkevics, Martins, Bobileva, Olga, Cirule, Helena, Gukalova, Baiba, Grinberga, Solveiga, Backlund, Maria, Simoff, Ivailo, Leber, Anna T, Berruga-Fernández, Talía, Antonov, Dmitry, Konda, Vivekananda R, Lindström, Stefan, Olanders, Gustav, Brandt, Peter, Baranczewski, Pawel, Vingsbo Lundberg, Carina, Liepinsh, Edgars, Suna, Edgars, Jones, T Alwyn, Mowbray, Sherry L, Hughes, Diarmaid, Karlén, Anders

“…Here, we describe the identification of an antibiotic class acting via LpxH, a clinically unexploited target in lipopolysaccharide synthesis. The…”
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ESAT-6 (EsxA) and TB10.4 (EsxH) based vaccines for pre- and post-exposure tuberculosis vaccination by Hoang, Truc, Aagaard, Claus, Dietrich, Jes, Cassidy, Joseph P, Dolganov, Gregory, Schoolnik, Gary K, Lundberg, Carina Vingsbo, Agger, Else Marie, Andersen, Peter

“…The ESX systems from Mycobacterium tuberculosis are responsible for the secretion of highly immunogenic proteins of key importance for bacterial survival and…”
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Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents by Arrazuria, Rakel, Kerscher, Bernhard, Huber, Karen E., Hoover, Jennifer L., Lundberg, Carina Vingsbo, Hansen, Jon Ulf, Sordello, Sylvie, Renard, Stephane, Aranzana-Climent, Vincent, Hughes, Diarmaid, Gribbon, Philip, Friberg, Lena E., Bekeredjian-Ding, Isabelle

“…Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop…”
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Expert workshop summary: Advancing toward a standardized murine model to evaluate treatments for antimicrobial resistance lung infections by Arrazuria, Rakel, Kerscher, Bernhard, Huber, Karen E., Hoover, Jennifer L., Lundberg, Carina Vingsbo, Hansen, Jon Ulf, Sordello, Sylvie, Renard, Stephane, Aranzana-Climent, Vincent, Hughes, Diarmaid, Gribbon, Philip, Friberg, Lena E., Bekeredjian-Ding, Isabelle

“…The rise in antimicrobial resistance (AMR), and increase in treatment-refractory AMR infections, generates an urgent need to accelerate the discovery and…”
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Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus by Harrison, Ewan M., Ba, Xiaoliang, Coll, Francesc, Blane, Beth, Restif, Olivier, Carvell, Henry, Köser, Claudio U., Jamrozy, Dorota, Reuter, Sandra, Lovering, Andrew, Gleadall, Nicholas, Bellis, Katherine L., Uhlemann, Anne-Catrin, Lowy, Franklin D., Massey, Ruth C., Grilo, Inês R., Sobral, Rita, Larsen, Jesper, Rhod Larsen, Anders, Vingsbo Lundberg, Carina, Parkhill, Julian, Paterson, Gavin K., Holden, Matthew T. G., Peacock, Sharon J., Holmes, Mark A.

“…Antibiotic resistance in bacterial pathogens threatens the future of modern medicine. One such resistant pathogen is methicillin-resistant Staphylococcus…”
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Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis by Becker, Katja, Cao, Sha, Nilsson, Anna, Erlandsson, Maria, Hotop, Sven-Kevin, Kuka, Janis, Hansen, Jon, Haldimann, Klara, Grinberga, Solveiga, Berruga-Fernández, Talia, Huseby, Douglas L., Shariatgorji, Reza, Lindmark, Evelina, Platzack, Björn, Böttger, Erik C., Crich, David, Friberg, Lena E., Vingsbo Lundberg, Carina, Hughes, Diarmaid, Brönstrup, Mark, Andrén, Per E., Liepinsh, Edgars, Hobbie, Sven N.

“…The clinical-stage drug candidate EBL-1003 (apramycin) represents a distinct new subclass of aminoglycoside antibiotics for the treatment of drug-resistant…”
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Pharmacokinetic and pharmacodynamic evaluation of the atypical tetracyclines chelocardin and amidochelocardin in murine infection models by Rox, Katharina, Jansen, Rolf, Lukežič, Tadeja, Greweling-Pils, Marina, Herrmann, Jennifer, Miethke, Marcus, Hüttel, Stephan, Hennessen, Fabienne, Abou Fayad, Antoine, Holzhausen, Cornelia, Lundberg, Carina Vingsbo, Teague, Joanne, Sudarman, Enge, Bülter, Lisa, Hesterkamp, Thomas, Stadler, Marc, Brönstrup, Mark, Müller, Rolf

“…There is a strong need to find novel treatment options against urinary tract infections associated with antimicrobial resistance. This study evaluates two…”
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CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations by Christensen, Dennis, Foged, Camilla, Rosenkrands, Ida, Lundberg, Carina Vingsbo, Andersen, Peter, Agger, Else Marie, Nielsen, Hanne Mørck

“…Mucosal administration of vaccines has many advantages compared to parenteral vaccination. Needle-free mucosal vaccination would be easily applicable, target…”
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Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice by Vingsbo Lundberg, Carina, Vaara, Timo, Frimodt-Møller, Niels, Vaara, Martti

“…Objectives Novel synthetic polymyxin derivatives including NAB737 and NAB739 are as effective as polymyxin B in vitro against the common opportunistic pathogen…”
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TB vaccine strategies—What is needed to solve a complex problem? by Dietrich, Jes, Vingsbo Lundberg, Carina, Andersen, Peter

“…An estimated 2 billion people are latently infected with Mycobacterium tuberculosis, the majority of which are already BCG vaccinated and repeatedly sensitized…”
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