Search Results - "Lund, Jennifer M."

Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells by Lee, Heung Kyu, Lund, Jennifer M., Ramanathan, Balaji, Mizushima, Noboru, Iwasaki, Akiko

“…Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain…”
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IPS-1 is essential for the control of West Nile virus infection and immunity by Suthar, Mehul S, Ma, Daphne Y, Thomas, Sunil, Lund, Jennifer M, Zhang, Nu, Daffis, Stephane, Rudensky, Alexander Y, Bevan, Michael J, Clark, Edward A, Kaja, Murali-Krishna, Diamond, Michael S, Gale, Jr, Michael

“…The innate immune response is essential for controlling West Nile virus (WNV) infection but how this response is propagated and regulates adaptive immunity in…”
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Memory T cells possess an innate-like function in local protection from mucosal infection by Arkatkar, Tanvi, Davé, Veronica, Cruz Talavera, Irene, Graham, Jessica B, Swarts, Jessica L, Hughes, Sean M, Bell, Timothy A, Hock, Pablo, Farrington, Joe, Shaw, Ginger D, Kirby, Anna, Fialkow, Michael, Huang, Meei-Li, Jerome, Keith R, Ferris, Martin T, Hladik, Florian, Schiffer, Joshua T, Prlic, Martin, Lund, Jennifer M

“…Mucosal infections pose a significant global health burden. Antigen-specific tissue-resident T cells are critical to maintaining barrier immunity. Previous…”
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Cutting Edge: Plasmacytoid Dendritic Cells Provide Innate Immune Protection against Mucosal Viral Infection In Situ by Lund, Jennifer M, Linehan, Melissa M, Iijima, Norifumi, Iwasaki, Akiko

“…Dendritic cells (DCs) are powerful APCs capable of activating naive lymphocytes. Of the DC subfamilies, plasmacytoid DCs (pDCs) are unique in that they secrete…”
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Differentiation of Regulatory Foxp3⁺ T Cells in the Thymic Cortex by Liston, Adrian, Nutsch, Katherine M., Farr, Andrew G., Lund, Jennifer M., Rasmussen, Jeffery P., Koni, Pandelakis A., Rudensky, Alexander Y.

“…Regulatory Foxp3⁺ T cells $({\rm T}_{{\rm R}})$ are indispensable for preventing autoimmune pathology in multiple organs and tissues. During thymic…”
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Recognition of Single-Stranded RNA Viruses by Toll-Like Receptor 7 by Lund, Jennifer M., Alexopoulou, Lena, Sato, Ayuko, Karow, Margaret, Adams, Niels C., Gale, Nicholas W., Iwasaki, Akiko, Flavell, Richard A.

“…Viral infection of mammalian host results in the activation of innate immune responses. Toll-like receptors (TLRs) have been shown to mediate the recognition…”
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Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross by Graham, Jessica B., Swarts, Jessica L., Mooney, Michael, Choonoo, Gabrielle, Jeng, Sophia, Miller, Darla R., Ferris, Martin T., McWeeney, Shannon, Lund, Jennifer M.

“…The Collaborative Cross (CC) is a panel of reproducible recombinant inbred mouse strains with high levels of standing genetic variation, affording an…”
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Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice by Graham, Jessica B, Swarts, Jessica L, Leist, Sarah R, Schäfer, Alexandra, Menachery, Vineet D, Gralinski, Lisa E, Jeng, Sophia, Miller, Darla R, Mooney, Michael A, McWeeney, Shannon K, Ferris, Martin T, Pardo-Manuel de Villena, Fernando, Heise, Mark T, Baric, Ralph S, Lund, Jennifer M

“…The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of…”
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Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes by Graham, Jessica B, Thomas, Sunil, Swarts, Jessica, McMillan, Aimee A, Ferris, Martin T, Suthar, Mehul S, Treuting, Piper M, Ireton, Renee, Gale, Jr, Michael, Lund, Jennifer M

“…West Nile virus (WNV) is an emerging neuroinvasive flavivirus that now causes significant morbidity and mortality worldwide. The innate and adaptive immune…”
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A Mouse Model of Chronic West Nile Virus Disease by Graham, Jessica B, Swarts, Jessica L, Wilkins, Courtney, Thomas, Sunil, Green, Richard, Sekine, Aimee, Voss, Kathleen M, Ireton, Renee C, Mooney, Michael, Choonoo, Gabrielle, Miller, Darla R, Treuting, Piper M, Pardo Manuel de Villena, Fernando, Ferris, Martin T, McWeeney, Shannon, Gale, Jr, Michael, Lund, Jennifer M

“…Infection with West Nile virus (WNV) leads to a range of disease outcomes, including chronic infection, though lack of a robust mouse model of chronic WNV…”
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Tregs control the development of symptomatic West Nile virus infection in humans and mice by Lanteri, Marion C, O'Brien, Katie M, Purtha, Whitney E, Cameron, Mark J, Lund, Jennifer M, Owen, Rachel E, Heitman, John W, Custer, Brian, Hirschkorn, Dale F, Tobler, Leslie H, Kiely, Nancy, Prince, Harry E, Ndhlovu, Lishomwa C, Nixon, Douglas F, Kamel, Hany T, Kelvin, David J, Busch, Michael P, Rudensky, Alexander Y, Diamond, Michael S, Norris, Philip J

“…West Nile virus (WNV) causes asymptomatic infection in most humans, but for undefined reasons, approximately 20% of immunocompetent individuals develop West…”
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Advances and challenges in studying the tissue‐resident T cell compartment in the human female reproductive tract by Lund, Jennifer M., Hladik, Florian, Prlic, Martin

“…Summary Tissue‐resident memory T cells (TRM) are considered to be central to maintaining mucosal barrier immunity and tissue homeostasis. Most of this…”
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Oral tolerance to systemic vaccination remains intact without RORγt expression in regulatory T cells by Potchen, Nicole B., Johnson, Andrew M.F., Hager, Kevin, Graham, Jessica, Van, Phuong, Lyn-Kew, Katelyn H., Warrier, Lakshmi, Talavera, Irene Cruz, Lund, Jennifer M., Kublin, James G.

“…Many promising vaccine candidates and licensed vaccines lead to variable immune responses within humans. Studies suggest that environmental exposures in the…”
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Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection by Da Costa, Andreia, Garza, Esteban, Graham, Jessica B., Swarts, Jessica L., Soerens, Andrew G., Gale, Michael, Lund, Jennifer M.

“…Given the rapid spread of flaviviruses such as West Nile virus (WNV) and Zika virus, it is critical that we develop a complete understanding of the key…”
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Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection by Graham, Jessica B., Swarts, Jessica L., Leist, Sarah R., Schäfer, Alexandra, Bell, Timothy A., Hock, Pablo, Farrington, Joe, Shaw, Ginger D., Ferris, Martin T., Pardo-Manuel de Villena, Fernando, Baric, Ralph S., Lund, Jennifer M.

“…The response to infection is generally heterogeneous and diverse, with some individuals remaining asymptomatic while others present with severe disease or a…”
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A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge by Edwards, Kristina R., Malhi, Harman, Schmidt, Karina, Davis, Amelia R., Homad, Leah J., Warner, Nikole L., Chhan, Crystal B., Scharffenberger, Samuel C., Gaffney, Karen, Hinkley, Troy, Potchen, Nicole B., Wang, Jing Yang, Price, Jason, McElrath, M. Juliana, Olson, James, King, Neil P., Lund, Jennifer M., Moodie, Zoe, Erasmus, Jesse H., McGuire, Andrew T.

“…Epstein-Barr virus (EBV) is associated with several malignancies, neurodegenerative disorders and is the causative agent of infectious mononucleosis. A vaccine…”
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A spotlight on heightened T cell complexity and relevance in mucosal tissues by Lund, Jennifer M.

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CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions by Richert-Spuhler, Laura E., Mar, Corinne M., Shinde, Paurvi, Wu, Feinan, Hong, Ting, Greene, Evan, Hou, Sharon, Thomas, Katherine, Gottardo, Raphael, Mugo, Nelly, de Bruyn, Guy, Celum, Connie, Baeten, Jared M., Lingappa, Jairam R., Lund, Jennifer M., Celum, Connie, Wald, Anna, Lingappa, Jairam R., Baeten, Jared M., Campbell, Mary S., Corey, Lawrence, Coombs, Robert W., Hughes, James P., Magaret, Amalia, McElrath, M. Juliana, Morrow, Rhoda, Mullins, James I., Coetzee, David, Fife, Kenneth, Were, Edwin, Essex, Max, Makhema, Joseph, Katabira, Elly, Ronald, Allan, Bukusi, Elizabeth, Cohen, Craig, Kapiga, Saidi, Manongi, Rachel, Farquhar, Carey, John-Stewart, Grace, Kiarie, James, Delany-Moretlwe, Sinead, Rees, Helen, de Bruyn, Guy, Gray, Glenda, McIntyre, James, Mugo, Nelly Rwamba, Donnell, Deborah, Frenkel, Lisa, Hendrix, Craig W., Tumwesigye, Elioda, Ndase, Patrick, Bukusi, Eliabeth, Wangisi, Jonathan, Campbell, James, Tappero, Jordan

“…We recently reported that the risk of sexually acquired HIV-1 infection is increased significantly by variants in the gene encoding CD101, a protein thought to…”
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Mucosal tissue regulatory T cells are integral in balancing immunity and tolerance at portals of antigen entry by Traxinger, Brianna R., Richert-Spuhler, Laura E., Lund, Jennifer M.

“…Foxp3+ regulatory T cells (Tregs) are a subset of CD4+ T cells that exert suppressive control over other immune cells. Tregs are critical for preventing…”
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Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells by Lund, Jennifer M, Hsing, Lianne, Pham, Thuy T, Rudensky, Alexander Y

“…Suppression of immune responses by regulatory T cells (Tregs) is thought to limit late stages of pathogen-specific immunity as a means of minimizing associated…”
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