Search Results - "Luna, Marian"

Targeting Survivin Enhances Chemosensitivity in Retinoblastoma Cells and Orthotopic Tumors by Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam, Lederman, Ariel, Kim, Jonathan, Gomer, Charles

“…Treatments for retinoblastoma (Rb) vary depending on the size and location of the intraocular lesions and include chemotherapy and radiation therapy. We…”
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Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response by FERRARIO, Angela, RUCKER, Natalie, WONG, Sam, LUNA, Marian, GOMER, Charles J

“…We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human…”
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Photodynamic therapy: Combined modality approaches targeting the tumor microenvironment by Gomer, Charles J., Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam

“…Background and Objectives Photodynamic therapy causes direct cytotoxicity to malignant cells within a tumor. Photodynamic therapy (PDT) can also have both…”
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Pro-apoptotic and anti-inflammatory properties of the green tea constituent epigallocatechin gallate increase photodynamic therapy responsiveness by Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam, Gomer, Charles J.

“…Background A polyphenol constituent of green tea, epigallocatechin gallate (EGCG), has anti‐carcinogenic properties. A growing number of studies document…”
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Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines by KESHELAVA, Nino, ZUO, Juan J, PING CHEN, WAIDYARATNE, Sitara N, LUNA, Marian C, GOMER, Charles J, TRICHE, Timothy J, REYNOLDS, C. Patrick

“…Neuroblastomas can acquire a sustained high-level drug resistance during chemotherapy and especially myeloablative chemoradiotherapy. p53 mutations are rare in…”
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Photodynamic therapy-mediated oxidative stress as a molecular switch for the temporal expression of genes ligated to the human heat shock promoter by LUNA, M. C, FERRARIO, A, WONG, S, FISHER, A. M. R, GOMER, C. J

“…Oxidative stress associated with photodynamic therapy (PDT) is a transcriptional inducer of genes encoding stress proteins, including those belonging to the…”
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Enhanced photodynamic therapy efficacy with inducible suicide gene therapy controlled by the grp promoter by LUNA, Marian C, XINKE CHEN, WONG, Sam, TSUI, Janet, RUCKER, Natalie, LEE, Amy S, GOMER, Charles J

“…Photodynamic therapy (PDT) is a promising cancer treatment involving the administration of a tumor-localizing photosensitizer followed by the photochemical…”
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Photodynamic therapy mediated induction of early response genes by LUNA, M. C, WONG, S, GOMER, C. J

“…Photodynamic therapy (PDT) generates reactive oxygen species which initiate the cytotoxic events of this tumor treatment. We demonstrate that PDT mediated…”
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Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors by Coricello, Adriana, El-Magboub, Asma, Luna, Marian, Ferrario, Angela, Haworth, Ian S., Gomer, Charles J., Aiello, Francesca, Adams, James D.

“…[Display omitted] Sesquiterpene compounds are widely known for their numerous pharmacological activities. Herein the focus of the authors was on α-Santonin, a…”
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Increased transcription and translation of heme oxygenase in Chinese hamster fibroblasts following photodynamic stress or Photofrin II incubation by Gomer, C J, Luna, M, Ferrario, A, Rucker, N

“…Porphyrin mediated photosensitization can enhance the transcription and translation of several oxidative stress genes. In this study, we report on the enhanced…”
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Isolation and initial characterization of mouse tumor cells resistant to porphyrin-mediated photodynamic therapy by LUNA, M. C, GOMER, C. J

“…Photodynamic therapy (PDT)-resistant variants of the RIF-1 mouse tumor cell line have been isolated following a protocol of repeated porphyrin incubation and…”
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Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapy-mediated tumor response by FERRARIO, Angela, VON TIEHL, Karl, WONG, Sam, LUNA, Marian, GOMER, Charles J

“…Photodynamic therapy (PDT) continues to be used in the treatment of solid tumors. Clinical results are promising, but the therapy has not been optimized, and…”
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Enhancement of photodynamic therapy by 2,5-dimethyl celecoxib, a non-cyclooxygenase-2 inhibitor analog of celecoxib by Ferrario, Angela, Lim, Sophia, Xu, Frank, Luna, Marian, Gaffney, Kevin J, Petasis, Nicos A, Schönthal, Axel H, Gomer, Charles J

“…Abstract Photodynamic therapy (PDT) effectiveness can be improved by employing combined modality approaches involving pharmaceuticals targeting the tumor…”
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Abstract 2512: Combining radiation or carboplatin with targeted inhibition of survivin increases treatment induced apoptosis in retinoblastoma cells by Luna, Marian, Ferrario, Angela, Rucker, Natalie, Wong, Sam, Gomer, Charles J.

“…The overarching goal of this project is to evaluate clinically relevant protocols to improve treatment responses for retinoblastoma (Rb). Procedures to treat…”
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Cyclooxygenase-2 Expression Induced by Photofrin Photodynamic Therapy Involves the p38 MAPK Pathway by Luna, Marian, Wong, Sam, Ferrario, Angela, Gomer, Charles J.

“…Photodynamic therapy (PDT), using the porphyrin photosensitizer Photofrin (PH), is approved for the clinical treatment of solid tumors. In addition to the…”
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Pro-apoptotic and anti-inflammatory properties of the green tea constituent epigallocatechin gallate increase photodynamic therapy responsiveness: EGCG ENHANCES PDT RESPONSIVENESS by Ferrario, Angela, Luna, Marian, Rucker, Natalie, Wong, Sam, Gomer, Charles J.

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Multiple Components of Photodynamic Therapy Can Phosphorylate Akt by Bozkulak, Ozguncem, Wong, Sam, Luna, Marian, Ferrario, Angela, Rucker, Natalie, Gulsoy, Murat, Gomer, Charles J.

“…A growing number of clinically relevant molecular and cellular responses are observed following photodynamic therapy (PDT). PDT‐mediated oxidative stress and…”
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Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors by Dong, Dezheng, Dubeau, Louis, Bading, James, Nguyen, Khoi, Luna, Marian, Yu, Hong, Gazit-Bornstein, Gadi, Gordon, Erlinda M, Gomer, Charles, Hall, Frederick L, Gambhir, Sanjiv S, Lee, Amy S

“…GRP78 is a stress-inducible chaperone protein with antiapoptotic properties that is overexpressed in transformed cells and cells under glucose starvation,…”
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CHOP activation by photodynamic therapy increases treatment induced photosensitization by Wong, Sam, Luna, Marian, Ferrario, Angela, Gomer, Charles J.

“…Background and Objectives C/EBP homologous protein (CHOP) is an endoplasmic reticulum (ER) stress inducible transcription factor involved in the development of…”
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Identification of MAP kinase pathways involved in COX-2 expression following photofrin photodynamic therapy by Luna, Marian, Ferrario, Angela, Wong, Sam, Gomer, Charles J

“…Photodynamic therapy (PDT) using the photosensitizer Photofrin is approved for the clinical treatment of solid tumors. PDT causes cytotoxic oxidative stress,…”
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