Search Results - "Luna, Brian"

Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges by Wong, Darren, Nielsen, Travis B, Bonomo, Robert A, Pantapalangkoor, Paul, Luna, Brian, Spellberg, Brad

“…SUMMARYAcinetobacter is a complex genus, and historically, there has been confusion about the existence of multiple species. The species commonly cause…”
Get full text

Natural history of Acinetobacter baumannii infection in mice by Luna, Brian M, Yan, Jun, Reyna, Zeferino, Moon, Eugene, Nielsen, Travis B, Reza, Hernan, Lu, Peggy, Bonomo, Robert, Louie, Arnold, Drusano, George, Bulitta, Jürgen, She, Rosemary, Spellberg, Brad

“…In 2017, the WHO identified Acinetobacter baumannii as the top priority for the development of new antibiotics. Despite the need for new antibiotics, there…”
Get full text

Vaccines targeting Staphylococcus aureus skin and bloodstream infections require different composition by Luna, Brian M, Nielsen, Travis B, Cheng, Brian, Pantapalangkoor, Paul, Yan, Jun, Boyle-Vavra, Susan, Bruhn, Kevin W, Montgomery, Christopher, Spellberg, Brad, Daum, Robert

“…Staphylococcus aureus infections represent a major public health threat, but previous attempts at developing a universal vaccine have been unsuccessful. We…”
Get full text

Monoclonal Antibody Requires Immunomodulation for Efficacy Against Acinetobacter baumannii Infection by Nielsen, Travis B, Yan, Jun, Luna, Brian M, Talyansky, Yuli, Slarve, Matthew, Bonomo, Robert A, Spellberg, Brad

“…Abstract Monoclonal antibodies (mAbs) are gaining significant momentum as novel therapeutics for infections caused by antibiotic-resistant bacteria. We…”
Get full text

Development of a Bispecific Antibody Targeting Clinical Isolates of Acinetobacter baumannii by Nielsen, Travis B, Yan, Jun, Slarve, Matthew, Li, Rachel, Junge, Jason A, Luna, Brian M, Wilkinson, Ian, Yerramalla, Udaya, Spellberg, Brad

“…Abstract Background We previously reported developing 2 anticapsular monoclonal antibodies (mAbs) as a novel therapy for Acinetobacter baumannii infections. We…”
Get full text

Capsule carbohydrate structure determines virulence in Acinetobacter baumannii by Talyansky, Yuli, Nielsen, Travis B, Yan, Jun, Carlino-Macdonald, Ulrike, Di Venanzio, Gisela, Chakravorty, Somnath, Ulhaq, Amber, Feldman, Mario F, Russo, Thomas A, Vinogradov, Evgeny, Luna, Brian, Wright, Meredith S, Adams, Mark D, Spellberg, Brad

“…Acinetobacter baumannii is a highly antibiotic-resistant bacterial pathogen for which novel therapeutic approaches are needed. Unfortunately, the drivers of…”
Get full text

Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis by Nielsen, Travis B., Pantapalangkoor, Paul, Luna, Brian M., Bruhn, Kevin W., Yan, Jun, Dekitani, Ken, Hsieh, Sarah, Yeshoua, Brandon, Pascual, Bryan, Vinogradov, Evgeny, Hujer, Kristine M., Domitrovic, T. Nicholas, Bonomo, Robert A., Russo, Thomas A., Lesczcyniecka, Magda, Schneider, Thomas, Spellberg, Brad

“…Background. Extremely drug-resistant (XDR) Acinetobacter baumannii is one of the most commonly encountered, highly resistant pathogens requiring novel…”
Get full text

Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates by Lu, Peggy, Alletto, Francesco, Lee, Bosul, Burk, Elizabeth, Martinez, Jasmine, Prati, Fabio, Caselli, Emilia, Spellberg, Brad, Luna, Brian

“…Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also…”
Get full text

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens by Yan, Jun, Nielsen, Travis B, Lu, Peggy, Talyansky, Yuli, Slarve, Matt, Reza, Hernan, Novakovic, Boris, Netea, Mihai G, Keller, Ashley E, Warren, Troy, DiGiandomenico, Antonio, Sellman, Bret R, Luna, Brian M, Spellberg, Brad

“…Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant, nosocomial pathogens that cause health care-associated infections. We…”
Get more information

Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics by Shin, Eunjeong, Zhang, Yongzhen, Zhou, Jieqiang, Lang, Yinzhi, Sayed, Alaa R M, Werkman, Carolin, Jiao, Yuanyuan, Kumaraswamy, Monika, Bulman, Zackery P, Luna, Brian M, Bulitta, Jürgen B

“…Aminoglycosides are important treatment options for serious lung infections, but modeling analyses to quantify their human lung epithelial lining fluid (ELF)…”
Get full text

Monoclonal Antibody Therapy against Acinetobacter baumannii by Nielsen, Travis B, Yan, Jun, Slarve, Matthew, Lu, Peggy, Li, Rachel, Ruiz, Juan, Lee, Bosul, Burk, Elizabeth, Talyansky, Yuli, Oelschlaeger, Peter, Hurth, Kyle, Win, William, Luna, Brian M, Bonomo, Robert A, Spellberg, Brad

“…Extremely drug-resistant (XDR) Acinetobacter baumannii is a notorious and frequently encountered pathogen demanding novel therapeutic interventions. An initial…”
Get full text

Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models by Jiao, Yuanyuan, Yan, Jun, Sutaria, Dhruvitkumar S, Lu, Peggy, Vicchiarelli, Michael, Reyna, Zeferino, Ruiz-Delgado, Juan, Burk, Elizabeth, Moon, Eugene, Shah, Nirav R, Spellberg, Brad, Bonomo, Robert A, Drusano, George L, Louie, Arnold, Luna, Brian M, Bulitta, Jürgen B

“…Amikacin is an FDA-approved aminoglycoside antibiotic that is commonly used. However, validated dosage regimens that achieve clinically relevant exposure…”
Get full text

Joint solution for PET image segmentation, denoising, and partial volume correction by Xu, Ziyue, Gao, Mingchen, Papadakis, Georgios Z., Luna, Brian, Jain, Sanjay, Mollura, Daniel J., Bagci, Ulas

“…•Interactions among segmentation, denoising, and partial volume corrections have been utilized to improve solution of each of these problems for PET…”
Get full text

Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice by Jiao, Yuanyuan, Yan, Jun, Vicchiarelli, Michael, Sutaria, Dhruvitkumar S, Lu, Peggy, Reyna, Zeferino, Spellberg, Brad, Bonomo, Robert A, Drusano, George L, Louie, Arnold, Luna, Brian M, Bulitta, Jürgen B

“…Polymyxin B is a "last-line-of-defense" antibiotic approved in the 1960s. However, the population pharmacokinetics (PK) of its four main components has not…”
Get full text

FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development by Byrne, James M, Waack, Ursula, Weinstein, Edward A, Joshi, Abhay, Shurland, Simone M, Iarikov, Dmitri, Bulitta, Jürgen B, Diep, Binh An, Guina, Tina, Hope, William W, Lawrenz, Matthew B, Lepak, Alexander J, Luna, Brian M, Miesel, Lynn, Phipps, Andrew J, Walsh, Thomas J, Weiss, William, Amini, Thushi, Farley, John J

“…The U.S. Food and Drug Administration (FDA) hosted a public workshop entitled "Advancing Animal Models for Antibacterial Drug Development" on 5 March 2020. The…”
Get full text

Environmental Spread of Antibiotic Resistance by Skandalis, Nicholas, Maeusli, Marlène, Papafotis, Dimitris, Miller, Sarah, Lee, Bosul, Theologidis, Ioannis, Luna, Brian

“…Antibiotic resistance represents a global health concern. Soil, water, livestock and plant foods are directly or indirectly exposed to antibiotics due to their…”
Get full text

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE by Nielsen, Travis B, Pantapalangkoor, Paul, Yan, Jun, Luna, Brian M, Dekitani, Ken, Bruhn, Kevin, Tan, Brandon, Junus, Justin, Bonomo, Robert A, Schmidt, Ann Marie, Everson, Michael, Duncanson, Frederick, Doherty, Terence M, Lin, Lin, Spellberg, Brad

“…For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that…”
Get full text

Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells by Qiu, Xiaolong, Lombardo, Jeremy A, Westerhof, Trisha M, Pennell, Marissa, Ng, Anita, Alshetaiwi, Hamad, Luna, Brian M, Nelson, Edward L, Kessenbrock, Kai, Hui, Elliot E, Haun, Jered B

“…Tissues are increasingly being analyzed at the single cell level in order to characterize cellular diversity and identify rare cell types. Single cell analysis…”
Get more information

Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria by Luna, Brian M, Ershova, Ksenia, Yan, Jun, Ulhaq, Amber, Nielsen, Travis B, Hsieh, Sarah, Pantapalangkoor, Paul, Vanscoy, Brian, Ambrose, Paul, Rudin, Sue, Hujer, Kristine, Bonomo, Robert A, Actis, Luis, Skaar, Eric P, Spellberg, Brad

“…Abstract Background New strategies are needed to slow the emergence of antibiotic resistance among bacterial pathogens. In particular, society is experiencing…”
Get full text

Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation by Kübler, André, Luna, Brian, Larsson, Christer, Ammerman, Nicole C, Andrade, Bruno B, Orandle, Marlene, Bock, Kevin W, Xu, Ziyue, Bagci, Ulas, Mollura, Daniel J, Marshall, John, Burns, Jay, Winglee, Kathryn, Ahidjo, Bintou Ahmadou, Cheung, Laurene S, Klunk, Mariah, Jain, Sanjay K, Kumar, Nathella Pavan, Babu, Subash, Sher, Alan, Friedland, Jon S, Elkington, Paul TG, Bishai, William R

“…Active tuberculosis (TB) often presents with advanced pulmonary disease, including irreversible lung damage and cavities. Cavitary pathology contributes to…”
Get full text