Search Results - "Lumpkin, Charles K."

Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues by Thrailkill, Kathryn M, Lumpkin, Jr, Charles K, Bunn, R Clay, Kemp, Stephen F, Fowlkes, John L

“…Diabetic osteoporosis is increasingly recognized as a significant comorbidity of type 1 diabetes mellitus. In contrast, type 2 diabetes mellitus is more…”
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The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes by Thrailkill, Kathryn M., MD, Nyman, Jeffry S., PhD, Bunn, R. Clay, PhD, Uppuganti, Sasidhar, MS, Thompson, Katherine L., PhD, Lumpkin, Charles K., PhD, Kalaitzoglou, Evangelia, MD, Fowlkes, John L., MD

“…Abstract Skeletal co-morbidities in type 1 diabetes include an increased risk for fracture and delayed fracture healing, which are intertwined with disease…”
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Palmitate and insulin synergistically induce IL-6 expression in human monocytes by Bunn, Robert C, Cockrell, Gael E, Ou, Yang, Thrailkill, Kathryn M, Lumpkin, Jr, Charles K, Fowlkes, John L

“…Insulin resistance is associated with a proinflammatory state that promotes the development of complications such as type 2 diabetes mellitus (T2DM) and…”
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SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice by Thrailkill, Kathryn M, Clay Bunn, R, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

“…Abstract Persons with type 1 and type 2 diabetes have increased fracture risk, attributed to deficits in the microarchitecture and strength of diabetic bone,…”
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Cisplatin inhibits bone healing during distraction osteogenesis by Stine, Kimo C., Wahl, Elizabeth C., Liu, Lichu, Skinner, Robert A., VanderSchilden, Jacquelyn, Bunn, Robert C., Montgomery, Corey O., Suva, Larry J., Aronson, James, Becton, David L., Nicholas, Richard W., Swearingen, Christopher J., Lumpkin Jr, Charles K.

“…ABSTRACT Osteosarcoma (OS) is the most common malignant bone tumor affecting children and adolescents. Many patients are treated with a combination of…”
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Bone Formation Is Impaired in a Model of Type 1 Diabetes by THRAILKILL, Kathryn M, LICHU LIU, ARONSON, James, LUMPKIN, Charles K, WAHL, Elizabeth C, BUNN, Robert C, PERRIEN, Daniel S, COCKRELL, Gael E, SKINNER, Robert A, HOGUE, William R, CARVER, Adam A, FOWLKES, John L

“…Bone Formation Is Impaired in a Model of Type 1 Diabetes Kathryn M. Thrailkill 1 , Lichu Liu 2 , Elizabeth C. Wahl 2 , Robert C. Bunn 1 , Daniel S. Perrien 3 4…”
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Runt-Related Transcription Factor 2 (RUNX2) and RUNX2-Related Osteogenic Genes Are Down-Regulated throughout Osteogenesis in Type 1 Diabetes Mellitus by Fowlkes, John L, Bunn, R. Clay, Liu, Lichu, Wahl, Elizabeth C, Coleman, Hannah N, Cockrell, Gael E, Perrien, Daniel S, Lumpkin, Charles K, Thrailkill, Kathryn M

“…Type 1 diabetes mellitus is associated with a number of disorders of skeletal health, conditions that rely, in part, on dynamic bone formation. A mouse model…”
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Increasing duration of type 1 diabetes perturbs the strength–structure relationship and increases brittleness of bone by Nyman, Jeffry S, Even, Jesse L, Jo, Chan-Hee, Herbert, Erik G, Murry, Matthew R, Cockrell, Gael E, Wahl, Elizabeth C, Bunn, R. Clay, Lumpkin, Charles K, Fowlkes, John L, Thrailkill, Kathryn M

“…Abstract Type 1 diabetes (T1DM) increases the likelihood of a fracture. Despite serious complications in the healing of fractures among those with diabetes,…”
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Corrigendum to “SGLT2 inhibitor therapy improves blood glucose but does not prevent diabetic bone disease in diabetic DBA/2J male mice” [Bone 82 (2016) 101–107] by Thrailkill, Kathryn M, Bunn, R.C, Nyman, Jeffry S, Rettiganti, Mallikarjuna R, Cockrell, Gael E, Wahl, Elizabeth C, Uppuganti, Sasidhar, Lumpkin, Charles K, Fowlkes, John L

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Effects of Systemic and Local Administration of Recombinant Human IGF‐I (rhIGF‐I) on De Novo Bone Formation in an Aged Mouse Model by Fowlkes, John L, Thrailkill, Kathryn M, Liu, Lichu, Wahl, Elizabeth C, Bunn, Robert C, Cockrell, Gael E, Perrien, Daniel S, Aronson, James, Lumpkin, Charles K

“…DO was used in an aged mouse model to determine if systemically and/or locally administered rhIGF‐I improved osteoblastogenesis and new bone formation. Local…”
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Osteo-promoting effects of insulin-like growth factor I (IGF-I) in a mouse model of type 1 diabetes by Fowlkes, John L, Nyman, Jeffry S, Bunn, R. Clay, Jo, Chanhee, Wahl, Elizabeth C, Liu, Lichu, Cockrell, Gael E, Morris, Lindsey M, Lumpkin, Charles K, Thrailkill, Kathryn M

“…Abstract Objective Using a streptozotocin (STZ)-induced mouse model of type 1 diabetes (T1D), we have previously demonstrated that long-term diabetes inhibits…”
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Restoration of regenerative osteoblastogenesis in aged mice: Modulation of TNF by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Clark, Lindsey M, Ou, Yang, Isales, Carlos M, Badger, Thomas M, Ronis, Martin J, Sims, John, Lumpkin, Charles K

“…Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised…”
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Effects of long-term doxycycline on bone quality and strength in diabetic male DBA/2J mice by Fowlkes, John L, Nyman, Jeffry S, Bunn, R Clay, Cockrell, Gael E, Wahl, Elizabeth C, Rettiganti, Mallikarjuna R, Lumpkin, Jr, Charles K, Thrailkill, Kathryn M

“…In type 1 diabetes, diabetic bone disease (DBD) is characterized by decreased bone mineral density, a state of low bone turnover and an increased risk of…”
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Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis by Perrien, Daniel S, Brown, Elizabeth C, Fletcher, Terry W, Irby, David J, Aronson, James, Gao, Guan G, Skinner, Robert A, Hogue, William R, Feige, Ulrich, Suva, Larry J, Ronis, Martin J J, Badger, Thomas M, Lumpkin, Jr, Charles K

“…Chronic ethanol exposure inhibits rapid bone formation during distraction osteogenesis (DO; fracture and limb lengthening) and decreases volumetric bone…”
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Chronic Ethanol Consumption Inhibits Postlactational Anabolic Bone Rebuilding in Female Rats by Shankar, Kartik, Hidestrand, Mats, Liu, Xiaoli, Chen, Jin Ran, Haley, Rani, Perrien, Daniel S, Skinner, Robert A, Lumpkin, Charles K, Badger, Thomas M, Ronis, Martin J J

“…EtOH consumption significantly impaired anabolic rebuilding of bone after lactation. Lower BMD and BMC in EtOH‐fed rats were associated with decreased bone…”
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Distraction osteogenesis in TNF receptor 1 deficient mice is protected from chronic ethanol exposure by Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Skinner, Robert A, Ronis, Martin J.J, Lumpkin, Charles K

“…Abstract Distraction osteogenesis (DO) is an orthopedic protocol, which induces direct new bone formation as a result of the stimulating effects of mechanical…”
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Immunohistochemical Study of Osteopontin Expression During Distraction Osteogenesis in the Rat by Perrien, Daniel S, Brown, Elizabeth C, Aronson, James, Skinner, Robert A, Montague, Donna C, Badger, Thomas M, Lumpkin, Charles K., Jr

“…Distraction osteogenesis (DO) is a limb-lengthening procedure that combines mechanical tension stress with fracture healing to provide a unique opportunity for…”
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A novel mouse model for the study of the inhibitory effects of chronic ethanol exposure on direct bone formation by Wahl, Elizabeth C., Liu, Lichu, Perrien, Daniel S., Aronson, James, Hogue, William R., Skinner, Robert A., Hidestrand, Matts, Ronis, Martin J.J., Badger, Thomas M., Lumpkin, Charles K.

“…Excessive alcohol consumption has been reported to interfere with human bone homeostasis and repair in multiple ways. Previous studies have demonstrated that…”
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A novel rat model for the study of deficits in bone formation in type-2 diabetes by Liu, Zhendong, Aronson, James, Wahl, Elizabeth C, Liu, Lichu, Perrien, Daniel S, Kern, Phillip A, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Cockrell, Gael E, Skinner, Robert A, Lumpkin, Jr, Charles K

“…There is evidence to suggest that impairment in bone formation and/or turnover is associated with the metabolic abnormalities characteristic of type-2 diabetes…”
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Different Molecular Mechanisms Underlie Ethanol-Induced Bone Loss in Cycling and Pregnant Rats by Shankar, Kartik, Hidestrand, Mats, Haley, Rani, Skinner, Robert A, Hogue, William, Jo, Chan-Hee, Simpson, Pippa, Lumpkin, Charles K, Aronson, James, Badger, Thomas M, Ronis, Martin J. J

“…Chronic ethanol (EtOH) consumption can result in osteopenia. In the current study, we examined the modulation of EtOH-induced bone loss during pregnancy…”
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