Search Results - "Lummiss, Justin A. M."

A robotic platform for flow synthesis of organic compounds informed by AI planning by Coley, Connor W, Thomas, 3rd, Dale A, Lummiss, Justin A M, Jaworski, Jonathan N, Breen, Christopher P, Schultz, Victor, Hart, Travis, Fishman, Joshua S, Rogers, Luke, Gao, Hanyu, Hicklin, Robert W, Plehiers, Pieter P, Byington, Joshua, Piotti, John S, Green, William H, Hart, A John, Jamison, Timothy F, Jensen, Klavs F

“…The synthesis of complex organic molecules requires several stages, from ideation to execution, that require time and effort investment from expert chemists…”
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A General Decomposition Pathway for Phosphine-Stabilized Metathesis Catalysts: Lewis Donors Accelerate Methylidene Abstraction by McClennan, William L, Rufh, Stephanie A, Lummiss, Justin A. M, Fogg, Deryn E

“…Sterically accessible Lewis donors are shown to accelerate decomposition during catalysis, for a broad range of Grubbs-class metathesis catalysts. These…”
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Chemical Plants: High-Value Molecules from Essential Oils by Lummiss, Justin A. M, Oliveira, Kelley C, Pranckevicius, Alexandre M. T, Santos, Alexandra G, dos Santos, Eduardo N, Fogg, Deryn E

“…As society faces a future of dwindling petrochemical supplies at increasing cost, much attention has been focused on methods to degrade biomass into renewable…”
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The divergent effects of strong NHC donation in catalysis by Lummiss, Justin A M, Higman, Carolyn S, Fyson, Devon L, McDonald, Robert, Fogg, Deryn E

“…Strong σ-donation from NHC ligands (NHC = N-heterocyclic carbene) is shown to have profoundly conflicting consequences for the reactivity of transition-metal…”
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Olefin Metathesis at the Dawn of Implementation in Pharmaceutical and Specialty-Chemicals Manufacturing by Higman, Carolyn S., Lummiss, Justin A. M., Fogg, Deryn E.

“…The recent uptake of molecular metathesis catalysts in specialty‐chemicals and pharmaceutical manufacturing is reviewed. The metathesis industry: Olefin…”
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Decomposition of Olefin Metathesis Catalysts by Brønsted Base: Metallacyclobutane Deprotonation as a Primary Deactivating Event by Bailey, Gwendolyn A, Lummiss, Justin A. M, Foscato, Marco, Occhipinti, Giovanni, McDonald, Robert, Jensen, Vidar R, Fogg, Deryn E

“…Brønsted bases of widely varying strength are shown to decompose the metathesis-active Ru intermediates formed by the second-generation Hoveyda and Grubbs…”
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Donor-Induced Decomposition of the Grubbs Catalysts: An Intercepted Intermediate by Lummiss, Justin A. M, McClennan, William L, McDonald, Robert, Fogg, Deryn E

“…The σ-alkyl species RuCl2(CH2PCy3)(py)3 (3a) is intercepted on adding pyridine to the first-generation Grubbs catalyst 1a during RCM or to the isolated…”
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Operation of the Boomerang Mechanism in Olefin Metathesis Reactions Promoted by the Second-Generation Hoveyda Catalyst by Bates, Jennifer M, Lummiss, Justin A. M, Bailey, Gwendolyn A, Fogg, Deryn E

“…A long-standing question in olefin metathesis centers on whether the “release–return” (boomerang) mechanism contributes to the productivity of Hoveyda-class…”
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Towards More Efficient, Greener Syntheses through Flow Chemistry by Lummiss, Justin A.M., Morse, Peter D., Beingessner, Rachel L., Jamison, Timothy F.

“…Technological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal,…”
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Ethylene-Promoted versus Ethylene-Free Enyne Metathesis by Grotevendt, Anne G. D, Lummiss, Justin A. M, Mastronardi, Melanie L, Fogg, Deryn E

“…The role of ethylene in promoting metathesis of acetylenic enynes is probed within the context of ring-closing enyne metathesis, using first- and…”
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Computer-designed repurposing of chemical wastes into drugs by Wołos, Agnieszka, Koszelewski, Dominik, Roszak, Rafał, Szymkuć, Sara, Moskal, Martyna, Ostaszewski, Ryszard, Herrera, Brenden T., Maier, Josef M., Brezicki, Gordon, Samuel, Jonathon, Lummiss, Justin A. M., McQuade, D. Tyler, Rogers, Luke, Grzybowski, Bartosz A.

“…As the chemical industry continues to produce considerable quantities of waste chemicals 1 , 2 , it is essential to devise ‘circular chemistry’ 3 – 8 schemes…”
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Sterically Driven Olefin Metathesis: The Impact of Alkylidene Substitution on Catalyst Activity by Lummiss, Justin A. M, Perras, Frédéric A, McDonald, Robert, Bryce, David L, Fogg, Deryn E

“…The dramatic reactivity difference between the Grubbs metathesis catalysts and their resting-state methylidene derivatives was probed in an integrated…”
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Amine-Mediated Degradation in Olefin Metathesis Reactions that Employ the Second-Generation Grubbs Catalyst by Lummiss, Justin A. M., Ireland, Benjamin J., Sommers, Jacob M., Fogg, Deryn E.

“…Amine‐mediated decomposition during olefin metathesis reactions that employ the second‐generation Grubbs catalyst is studied. For most amines, the dominant…”
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Reactions of Grubbs Catalysts with Excess Methoxide: Formation of Novel Methoxyhydride Complexes by Beach, Nicholas J, Lummiss, Justin A. M, Bates, Jennifer M, Fogg, Deryn E

“…On exposure to NaOMe (≥3 equiv) in CH2Cl2–MeOH at 23 °C, the first-generation Grubbs catalyst RuCl2(PCy3)2(CHPh) (1a) is immediately transformed into the…”
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Clean, Convenient, High-yield Access to Second-generation Ru Metathesis Catalysts from Commercially Available Precursors by van Lierop, Bianca J., Reckling, Amy M., Lummiss, Justin A. M., Fogg, Deryn E.

“…Expedient routes are described to the three dominant ruthenium catalysts currently used for olefin metathesis: the second‐generation Grubbs, Hoveyda, and…”
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Inside Cover: Clean, Convenient, High-yield Access to Second-generation Ru Metathesis Catalysts from Commercially Available Precursors (ChemCatChem 12/2012) by van Lierop, Bianca J., Reckling, Amy M., Lummiss, Justin A. M., Fogg, Deryn E.

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Olefinmetathese als aufstrebende Methode zur Herstellung von Pharmazeutika und Spezialchemikalien by Higman, Carolyn S., Lummiss, Justin A. M., Fogg, Deryn E.

“…Dieser Kurzaufsatz behandelt die kürzliche Einführung molekularer Metathesekatalysatoren in die Produktion von Spezialchemikalien und Pharmazeutika. Die…”
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The divergent effects of strong NHC donation in catalysisElectronic supplementary information (ESI) available: Rate profiles for decomposition of u-GIIm and s-GIIm; X-ray crystallographic details; NOESY spectra, and derivation of the [PCy3]-independence of decomposition. CCDC 1400077. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc02592c by Lummiss, Justin A. M, Higman, Carolyn S, Fyson, Devon L, McDonald, Robert, Fogg, Deryn E

“…Strong σ-donation from NHC ligands (NHC = N-heterocyclic carbene) is shown to have profoundly conflicting consequences for the reactivity of transition-metal…”
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The divergent effects of strong NHC donation in catalysis† †Electronic supplementary information (ESI) available: Rate profiles for decomposition of u-GIIm and s-GIIm; X-ray crystallographic details; NOESY spectra, and derivation of the [PCy3]-independence of decomposition. CCDC 1400077. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc02592c by Lummiss, Justin A. M., Higman, Carolyn S., Fyson, Devon L., McDonald, Robert, Fogg, Deryn E.

“…The inverse relationship between NHC donicity and catalyst initiation. Strong σ-donation from NHC ligands (NHC = N-heterocyclic carbene) is shown to have…”
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