Search Results - "Lummis, Sarah CR"

Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site by Brams, Marijke, Govaerts, Cedric, Kambara, Kumiko, Price, Kerry L, Spurny, Radovan, Gharpure, Anant, Pardon, Els, Evans, Genevieve L, Bertrand, Daniel, Lummis, Sarah CR, Hibbs, Ryan E, Steyaert, Jan, Ulens, Chris

“…Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind…”
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Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles by O'Brien, John A, Lummis, Sarah C R

“…Biolistic transfection is proving an increasingly popular method of incorporating DNA or RNA into cells that are difficult to transfect using traditional…”
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Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies by Reeves, David C, Lummis, Sarah C R

“…The 5-HT3 receptor is a member of a neurotransmitter-gated ion channel family which includes nicotinic acetylcholine, GABAA, and glycine receptors. While…”
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The structural basis of function in Cys-loop receptors by Thompson, Andrew J, Lester, Henry A, Lummis, Sarah C R

“…Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are responsible for fast excitatory and inhibitory transmission in the…”
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Cis - trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel by Lester, Henry A, Dougherty, Dennis A, Lee, Lori W, Broadhurst, R. William, Lummis, Sarah C. R, Beene, Darren L

“…5-Hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening…”
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The 5-HT3 receptor as a therapeutic target by Thompson, Andrew J, Lummis, Sarah C R

“…The 5-HT3 receptor is a neurotransmitter-gated ion channel. It is a member of the Cys-loop family of receptors, which also includes nicotinic acetylcholine,…”
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An atypical residue in the pore of Varroa destructor GABA-activated RDL receptors affects picrotoxin block and thymol modulation by Price, Kerry L., Lummis, Sarah C.R.

“…GABA-activated RDL receptors are the insect equivalent of mammalian GABAA receptors, and play a vital role in neurotransmission and insecticide action. Here we…”
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Modulation of the Erwinia ligand-gated ion channel and the 5-HT.sub.3 receptor via a common vestibule site by Brams, Marijke, Govaerts, Cedric, Kambara, Kumiko, Price, Kerry L, Spurny, Radovan, Gharpure, Anant, Pardon, Els, Evans, Genevieve L, Bertrand, Daniel, Lummis, Sarah CR, Hibbs, Ryan E, Steyaert, Jan, Ulens, Chris

“…Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind…”
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Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia by Schaefer, Natascha, Kluck, Christoph J, Price, Kerry L, Meiselbach, Heike, Vornberger, Nadine, Schwarzinger, Stephan, Hartmann, Stephanie, Langlhofer, Georg, Schulz, Solveig, Schlegel, Nadja, Brockmann, Knut, Lynch, Bryan, Becker, Cord-Michael, Lummis, Sarah C R, Villmann, Carmen

“…Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the…”
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GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study by Ashby, Jamie A., McGonigle, Ian V., Price, Kerry L., Cohen, Netta, Comitani, Federico, Dougherty, Dennis A., Molteni, Carla, Lummis, Sarah C.R.

“…RDL receptors are GABA-activated inhibitory Cys-loop receptors found throughout the insect CNS. They are a key target for insecticides. Here, we characterize…”
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The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine by Ulens, Chris, Spurny, Radovan, Thompson, Andrew J., Alqazzaz, Mona, Debaveye, Sarah, Han, Lu, Price, Kerry, Villalgordo, Jose M., Tresadern, Gary, Lynch, Joseph W., Lummis, Sarah C.R.

“…Pentameric ligand-gated ion channels (pLGIC) catalyze the selective transfer of ions across the cell membrane in response to a specific neurotransmitter. A…”
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Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models by Comitani, Federico, Cohen, Netta, Ashby, Jamie, Botten, Dominic, Lummis, Sarah C. R., Molteni, Carla

“…The resistance to dieldrin (RDL) receptor is an insect pentameric ligand-gated ion channel (pLGIC). It is activated by the neurotransmitter γ-aminobutyric acid…”
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Phenylalanine in the Pore of the Erwinia Ligand-Gated Ion Channel Modulates Picrotoxinin Potency but Not Receptor Function by Thompson, Andrew J, Alqazzaz, Mona, Price, Kerry L, Weston, David A, Lummis, Sarah C. R

“…The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of eukaryotic Cys-loop ligand-gated ion channels. This protein has the potential to be a…”
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GABA sub(A) receptor modulation by terpenoids from Sideritis extracts by Kessler, Artur, Sahin-Nadeem, Hilal, Lummis, Sarah CR, Weigel, Ingrid, Pischetsrieder, Monika, Buettner, Andrea, Villmann, Carmen

“…Scope GABA sub(A) receptors are modulated by Sideritis extracts. The aim of this study was to identify single substances from Sideritis extracts responsible…”
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Cys-Loop Receptor Channel Blockers Also Block GLIC by Alqazzaz, Mona, Thompson, Andrew J., Price, Kerry L., Breitinger, Hans-Georg, Lummis, Sarah C.R.

“…The Gloeobacter ligand-gated ion channel (GLIC) is a bacterial homolog of vertebrate Cys-loop ligand-gated ion channels. Its pore-lining region in particular…”
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A single amino acid determines the toxicity of Ginkgo biloba extracts by Thompson, Andrew J., McGonigle, Ian, Duke, Rujee, Johnston, Graham A. R., Lummis, Sarah C. R.

“…Ginkgo biloba extracts are currently used for a wide range of health‐related conditions. Some of the medical benefits of these extracts are controversial, but…”
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Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT 3 receptor via a common vestibule site by Brams, Marijke, Govaerts, Cedric, Kambara, Kumiko, Price, Kerry L, Spurny, Radovan, Gharpure, Anant, Pardon, Els, Evans, Genevieve L, Bertrand, Daniel, Lummis, Sarah Cr, Hibbs, Ryan E, Steyaert, Jan, Ulens, Chris

“…Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind…”
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Molecular Dynamics Simulations of GABA Binding to the GABA sub(C Receptor: The Role of Arg[super]104) by Melis, Claudio, Lummis, Sarah CR, Molteni, Carla

“…GABA is the major inhibitory neurotransmitter in the nervous system and acts at a variety of receptors including GABA sub(C receptors, which are a subclass of…”
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Diolistic labeling of neuronal cultures and intact tissue using a hand-held gene gun by Lummis, Sarah C R, O'Brien, John A

“…Diolistic labeling is a highly efficient method for introducing dyes into cells using biolistic techniques. The use of lipophilic carbocyanine dyes, combined…”
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Mixed antagonistic effects of the ginkgolides at recombinant human rho 1 GABA sub(C) receptors by Huang, Shelley H, Lewis, Trevor M, Lummis, Sarah CR, Thompson, Andrew J, Chebib, Mary, Johnston, Graham AR, Duke, Rujee K

“…The diterpene lactones of Ginkgo biloba, ginkgolides A, B and C are antagonists at a range of Cys-loop receptors. This study examined the effects of the…”
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