Search Results - "Lummis, S C R"

The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5‐HT3 receptors by Thompson, A J, Lochner, M, Lummis, S C R

“…Background and Purpose: The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys‐loop receptors and…”
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5-HT3 receptors by Thompson, A J, Lummis, S C R

“…The 5-HT(3) receptor is a member of the Cys-loop family of ligand-gated ion channels. These receptors are located in both the peripheral and central nervous…”
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Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor by Thompson, A J, Duke, R K, Lummis, S C R

“…Bilobalide (BB), ginkgolide B (GB), diltiazem (DTZ), and picrotoxinin (PXN) are 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonists in which the…”
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Characterisation of thymol effects on RDL receptors from the bee parasite Varroa destructor by Price, K.L., Lummis, S.C.R.

“…A major contributor to bee colony decline is infestation with its most devastating pest, the mite Varroa destructor. To control these mites, thymol is often…”
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Discriminating between 5‐HT3A and 5‐HT3AB receptors by Thompson, AJ, Lummis, SCR

“…The 5‐HT3B subunit was first cloned in 1999, and co‐expression with the 5‐HT3A subunit results in heteromeric 5‐HT3AB receptors that are functionally distinct…”
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Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5‐HT3AB receptors by Thompson, A. J., Price, K. L., Lummis, S. C. R.

“…Non‐technical summary  Nerve signals are transmitted across cell membranes by receptors that can consist of multiple different subunits. The 5‐HT3 receptor is…”
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A single channel mutation alters agonist efficacy at 5‐HT3A and 5‐HT3AB receptors by Thompson, A J, Lummis, S C R

“…Background and Purpose 5‐HT3 receptors are composed of 5‐HT3A subunits (homomeric receptors), or combinations of 5‐HT3A and other 5‐HT3 receptor subunits…”
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Loop B Is a Major Structural Component of the 5-HT3 Receptor by Thompson, A.J., Lochner, M., Lummis, S.C.R.

“…The 5-HT3 receptor belongs to a family of therapeutically important neurotransmitter-gated receptors whose ligand binding sites are formed by the convergence…”
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VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors by Thompson, A J, Verheij, M H P, de Esch, I J P, Lummis, S C R

“…The actions of a novel, potent 5-HT₃ receptor ligand, [2-chloro-(4-methylpiperazine-1-yl)quinoxaline (VUF10166)], were examined at heterologously expressed…”
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Different efficacy of specific agonists at 5‐HT3 receptor splice variants: the role of the extra six amino acid segment by Niemeyer, M‐I., Lummis, S C R.

“…Whole cell voltage clamp electrophysiology and radioligand binding were used to examine the agonist characteristics of the two splice variants of the 5‐HT3…”
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Unbinding pathways of an agonist and an antagonist from the 5-HT3 receptor by Thompson, A J, Chau, P-L, Chan, S L, Lummis, S C R

“…The binding sites of 5-HT3 and other Cys-loop receptors have been extensively studied, but there are no data on the entry and exit routes of ligands for these…”
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Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides by Wafford, K. A., Lummis, S. C. R., Sattelle, David B.

“…The effects of a cyclodiene (endrin) and a cyclohexane (lindane) insecticide have been tested on γ-aminobutyric acid (GABA) receptors in the central nervous…”
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A single channel mutation alters agonist efficacy at 5‐ HT 3 A and 5‐ HT 3 AB receptors by Thompson, A J, Lummis, S C R

“…Background and Purpose 5‐ HT 3 receptors are composed of 5‐ HT 3 A subunits (homomeric receptors), or combinations of 5‐ HT 3 A and other 5‐ HT 3 receptor…”
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A single channel mutation alters agonist efficacy at 5-HT sub(3)A and 5-HT sub(3)AB receptors by Thompson, A J, Lummis, S C R

“…Background and Purpose 5-HT sub(3) receptors are composed of 5-HT sub(3)A subunits (homomeric receptors), or combinations of 5-HT sub(3)A and other 5-HT sub(3)…”
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Agonists and Antagonists Bind to an A-A Interface in the Heteromeric 5-HT3AB Receptor by Lochner, M., Lummis, S.C.R.

“…The 5-HT3 receptor is a member of the Cys-loop family of transmitter receptors. It can function as a homopentamer (5-HT3A-only subunits) or as a…”
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Antimalarial drugs inhibit human 5‐HT 3 and GABA A but not GABA C receptors by Thompson, A J, Lummis, S C R

“…Background and purpose: Antimalarial compounds have been previously shown to inhibit rodent nicotinic acetylcholine (nACh) and 5‐HT 3 receptors. Here, we…”
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Structural basis of ligand recognition in 5-HT3 receptors by Kesters, Divya, Thompson, Andrew J, Brams, Marijke, van Elk, René, Spurny, Radovan, Geitmann, Matthis, Villalgordo, Jose M, Guskov, Albert, Helena Danielson, U, Lummis, Sarah C R, Smit, August B, Ulens, Chris

“…The 5‐HT 3 receptor is a pentameric serotonin‐gated ion channel, which mediates rapid excitatory neurotransmission and is the target of a therapeutically…”
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The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5‐HT 3 receptors by Thompson, A J, Lochner, M, Lummis, S C R

“…Background and Purpose: The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys‐loop receptors and…”
Get full text

Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5‐HT 3 AB receptors by Thompson, A. J., Price, K. L., Lummis, S. C. R.

“…Non‐technical summary  Nerve signals are transmitted across cell membranes by receptors that can consist of multiple different subunits. The 5‐HT 3 receptor is…”
Get full text

Different efficacy of specific agonists at 5‐HT 3 receptor splice variants: the role of the extra six amino acid segment by Niemeyer, M‐I., Lummis, S C R.

“…Whole cell voltage clamp electrophysiology and radioligand binding were used to examine the agonist characteristics of the two splice variants of the 5‐HT 3…”
Get full text