Search Results - "Lumb, M J"

The business management training needs of South African Biokineticists to ensure business sustainability by Lumb, Michael James, Marais, Karel

“…Background: Business management training is essential for success in the modern era. Health and medical professionals are exposed to knowledge that allows them…”
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Functional Synergism between the Most Common Polymorphism in Human Alanine:Glyoxylate Aminotransferase and Four of the Most Common Disease-causing Mutations by Lumb, Michael J., Danpure, Christopher J.

“…The autosomal recessive disorder primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent enzyme…”
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Expert consensus on the terminology, diagnostics and management of persisting symptoms after concussion with a focus on mental health, postural stability, electroencephalogram and balance testing: A cross-sectional Delphi-like survey by Lumb, MJ, Welman, K, Snegireva, N

“…\r\nBackground\r\nPersisting symptoms after concussion (PSaC) are a pathological manifestation of head injuries that present with symptoms after the acute…”
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Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation by DANPURE, C. J, PURDUE, P. E, DAVIDSON, N. O, FRYER, P, GRIFFITHS, S, ALLSOP, J, LUMB, M. J, GUTTRIDGE, K. M, JENNINGS, P. R, SCHEINMAN, J. I, MAUER, S. M

“…Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate…”
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Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase by Purdue, P E, Lumb, M J, Fox, M, Griffo, G, Hamon-Benais, C, Povey, S, Danpure, C J

“…We have previously reported the isolation of a genomic clone encoding human liver-specific peroxisomal alanine:glyoxylate aminotransferase (AGT, EC 2.6.1.44),…”
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Targeting of alanine: glyoxylate aminotransferase in normal individuals and its mistargeting in patients with primary hyperoxaluria type 1 by Danpure, C J, Jennings, P R, Leiper, J M, Lumb, M J, Oatey, P B

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An intronic duplication in the alanine : glyoxylate aminotransferase gene facilitates identification of mutations in compound heterozygote patients with primary hyperoxaluria type 1 by EDWARD PURDUE, P, LUMB, M. J, ALLSOP, J, DANPURE, C. J

“…We report here the identification of a duplication within the first intron of the gene encoding human alanine:glyoxylate aminotransferase (AGT); this…”
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Molecular characterization and clinical use of a polymorphic tandem repeat in an intron of the human alanine:glyoxylate aminotransferase gene by DANPURE, C. J, BIRDSEY, G. M, RUMSBY, G, LUMB, M. J, PURDUE, P. E, ALLSOP, J

“…The autosomal recessive disease primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate…”
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A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1 by Purdue, P E, Lumb, M J, Allsop, J, Minatogawa, Y, Danpure, C J

“…We have synthesized and sequenced alanine:glyoxylate aminotransferase (AGT; HGMW-approved symbol for the gene--AGXT) cDNA from the liver of a primary…”
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Context dependency of the PTS1 motif in human alanine: glyoxylate aminotransferase 1 by Oatey, P B, Lumb, M J, Jennings, P R, Danpure, C J

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Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting : analysis of the feline gene by LUMB, M. J, PURDUE, P. E, DANPURE, C. J

“…The subcellular distribution of hepatic alanine:glyoxylate aminotransferase 1 (AGT) has changed, under the influence of dietary selection pressure, on several…”
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Effect of N-terminal alpha-helix formation on the dimerization and intracellular targeting of alanine:glyoxylate aminotransferase by Lumb, M J, Drake, A F, Danpure, C J

“…The unparalleled peroxisome-to-mitochondrion mistargeting of alanine:glyoxylate aminotransferase (AGT) in the hereditary disease primary hyperoxaluria type 1…”
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Folinic acid protection against nitrous oxide teratogenicity in the rat by Keeling, P A, Rocke, D A, Nunn, J F, Monk, S J, Lumb, M J, Halsey, M J

“…The Sprague-Dawley rat was used to demonstrate the effect of nitrous oxide, with and without folinic pretreatment, on reproductive indices and fetal…”
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Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting : analysis of the marmoset and rabbit genes by PURDUE, P. E, LUMB, M. J, DANPURE, C. J

“…In mammals, the subcellular distribution of alanine:glyoxylate aminotransferase 1 (AGT) is species dependent, with the proportion of AGT targeted to…”
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Mammalian Alanine/Glyoxylate Aminotransferase 1 Is Imported into Peroxisomes via the PTS1 Translocation Pathway. Increased Degeneracy and Context Specificity of the Mammalian PTS1 Motif and Implications for the Peroxisome-to-Mitochondrion Mistargeting of AGT in Primary Hyperoxaluria Type 1 by Motley, Alison, Lumb, Michael J., Oatey, Paru B., Jennings, Patricia R., De Zoysa, Priyal A., Ronald J. A. Wanders, Tabak, Henk F., Danpure, Christopher J.

“…Alanine/glyoxylate aminotransferase 1 (AGT) is peroxisomal in most normal humans, but in some patients with the hereditary disease primary hyperoxaluria type 1…”
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Enzymological and mutational analysis of a complex primary hyperoxaluria type I phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation by Danpure, C J, Purdue, P E, Fryer, P, Griffiths, S, Allsop, J, Lumb, MJ, Guttridge, K M, Jennings, PR, Davidson, N O

“…Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disease caused by a deficiency of the liver-specific peroxisomal enzyme alanine:glyoxylate…”
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A four-week home-based exercise programme is effective in treating subacute low back pain in adults by Lategan, L., Lumb, M.J.

“…Background: Low back pain (LBP) is a prevalent condition affecting a large portion of the population worldwide and it is one of the leading causes of morbidity…”
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Vitamin B12, folate and nitrous oxide by Deacon, R, Lumb, M J, Perry, J

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Molecular Basis of the Variable Mitochondrial and Peroxisomal Localisation of Alanine‐Glyoxylate Aminotransferase by Oatey, Paru B., Lumb, Michael J., Danpure, Christopher J.

“…The molecular basis of the variable species‐specific peroxisomal andor mitochondrial targeting of the enzyme alanine‐glyoxylate aminotransferase 1 (AGT) has…”
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Correction of an enzyme trafficking defect in hereditary kidney stone disease in vitro by Lumb, Michael J, Birdsey, Graeme M, Danpure, Christopher J

“…In normal human hepatocytes, the intermediary-metabolic enzyme alanine:glyoxylate aminotransferase (AGT) is located within the peroxisomes. However, in approx…”
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