Search Results - "Lumb, Jennifer"

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity by Cao, Jennifer Yinuo, Poddar, Aunoy, Magtanong, Leslie, Lumb, Jennifer H., Mileur, Trevor R., Reid, Michael A., Dovey, Cole M., Wang, Jin, Locasale, Jason W., Stone, Everett, Cole, Susan P.C., Carette, Jan E., Dixon, Scott J.

“…The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell…”
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An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome by Allison, Rachel, Lumb, Jennifer H, Fassier, Coralie, Connell, James W, Ten Martin, Daniel, Seaman, Matthew N J, Hazan, Jamilé, Reid, Evan

“…Mechanisms coordinating endosomal degradation and recycling are poorly understood, as are the cellular roles of microtubule (MT) severing. We show that cells…”
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The AAA ATPase spastin links microtubule severing to membrane modelling by Lumb, Jennifer H., Connell, James W., Allison, Rachel, Reid, Evan

“…In 1999, mutations in the gene encoding the microtubule severing AAA ATPase spastin were identified as a major cause of a genetic neurodegenerative condition…”
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The adherens junctions control susceptibility to Staphylococcus aureus α-toxin by Popov, Lauren M, Marceau, Caleb D, Starkl, Philipp M, Lumb, Jennifer H, Shah, Jimit, Guerrera, Diego, Cooper, Rachel L, Merakou, Christina, Bouley, Donna M, Meng, Wenxiang, Kiyonari, Hiroshi, Takeichi, Masatoshi, Galli, Stephen J, Bagnoli, Fabio, Citi, Sandra, Carette, Jan E, Amieva, Manuel R

“…Staphylococcus aureus is both a transient skin colonizer and a formidable human pathogen, ranking among the leading causes of skin and soft tissue infections…”
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DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes by Lumb, Jennifer H., Li, Qin, Popov, Lauren M., Ding, Siyuan, Keith, Marie T., Merrill, Bryan D., Greenberg, Harry B., Li, Jin Billy, Carette, Jan E.

“…The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation…”
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Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia by Newton, Timothy, Allison, Rachel, Edgar, James R, Lumb, Jennifer H, Rodger, Catherine E, Manna, Paul T, Rizo, Tania, Kohl, Zacharias, Nygren, Anders O H, Arning, Larissa, Schüle, Rebecca, Depienne, Christel, Goldberg, Lisa, Frahm, Christiane, Stevanin, Giovanni, Durr, Alexandra, Schöls, Ludger, Winner, Beate, Beetz, Christian, Reid, Evan

“…The mechanisms underlying disease modifier gene effects are rarely understood. Newton et al. report that deletion of DPY30 reduces age at onset in hereditary…”
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Honey bee Royalactin unlocks conserved pluripotency pathway in mammals by Wan, Derrick C., Morgan, Stefanie L., Spencley, Andrew L., Mariano, Natasha, Chang, Erin Y., Shankar, Gautam, Luo, Yunhai, Li, Ted H., Huh, Dana, Huynh, Star K., Garcia, Jasmine M., Dovey, Cole M., Lumb, Jennifer, Liu, Ling, Brown, Katharine V., Bermudez, Abel, Luong, Richard, Zeng, Hong, Mascetti, Victoria L., Pitteri, Sharon J., Wang, Jordon, Tu, Hua, Quarta, Marco, Sebastiano, Vittorio, Nusse, Roel, Rando, Thomas A., Carette, Jan E., Bazan, J. Fernando, Wang, Kevin C.

“…Royal jelly is the queen-maker for the honey bee Apis mellifera , and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite…”
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Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways by Lumb, Jennifer H, Leung, Ka Fai, Dubois, Kelly N, Field, Mark C

“…Early endosomal cargo is typically targeted to either a degradative or recycling pathway. Despite established functions for the retromer and ESCRT complexes at…”
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Rab23 is a flagellar protein in Trypanosoma brucei by Lumb, Jennifer H, Field, Mark C

“…Rab small GTPases are important mediators of membrane transport, and orthologues frequently retain similar locations and functions, even between highly…”
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A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef by Choma, Maja K, Lumb, Jennifer, Kozik, Patrycja, Robinson, Margaret S

“…The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef's functions is to keep MHC class I off the surface of infected cells, a…”
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Macromolecular Trafficking and Immune Evasion in African Trypanosomes by Field, Mark C, Lumb, Jennifer H, Adung'a, Vincent O, Jones, Nicola G, Engstler, Markus

“…Intracellular trafficking is a major mechanism contributing to maintenance of the surface composition in most eukaryotic cells. In the case of unicellular…”
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The adherens junctions control susceptibility toStaphylococcus aureusα-toxin by Popov, Lauren M., Marceau, Caleb D., Starkl, Philipp M., Lumb, Jennifer H., Shah, Jimit, Guerrera, Diego, Cooper, Rachel L., Merakou, Christina, Bouley, Donna M., Meng, Wenxiang, Kiyonari, Hiroshi, Takeichi, Masatoshi, Galli, Stephen J., Bagnoli, Fabio, Citi, Sandra, Carette, Jan E., Amieva, Manuel R.

“…Staphylococcus aureusis both a transient skin colonizer and a formidable human pathogen, ranking among the leading causes of skin and soft tissue infections as…”
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The adherens junctions control susceptibility to Staphylococcus aureus [alpha]-toxin by Popov, Lauren M, Marceau, Caleb D, Starkl, Philipp M, Lumb, Jennifer H, Shah, Jimit, Guerrera, Diego, Cooper, Rachel L, Merakou, Christina, Bouley, Donna M, Meng, Wenxiang, Kiyonari, Hiroshi, Takeichi, Masatoshi, Galli, Stephen J, Bagnoli, Fabio, Citi, Sandra, Carette, Jan E, Amieva, Manuel R

“…Staphylococcus aureus is both a transient skin colonizer and a formidable human pathogen, ranking among the leading causes of skin and soft tissue infections…”
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A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef: e0140404 by Choma, Maja K, Lumb, Jennifer, Kozik, Patrycja, Robinson, Margaret S

“…The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef's functions is to keep MHC class I off the surface of infected cells, a…”
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Chapter 1 Macromolecular Trafficking and Immune Evasion in African Trypanosomes by Field, Mark C., Lumb, Jennifer H., Adung'a, Vincent O., Jones, Nicola G., Engstler, Markus

“…Intracellular trafficking is a major mechanism contributing to maintenance of the surface composition in most eukaryotic cells. In the case of unicellular…”
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Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness by Feng, Allan, Yang, Emily Y, Moore, Andrew Reese, Dhingra, Shaurya, Chang, Sarah Esther, Yin, Xihui, Pi, Ruoxi, Mack, Elisabeth Km, Völkel, Sara, Geßner, Reinhard, Gündisch, Margrit, Neubauer, Andreas, Renz, Harald, Tsiodras, Sotirios, Fragkou, Paraskevi C, Asuni, Adijat A, Levitt, Joseph E, Wilson, Jennifer G, Leong, Michelle, Lumb, Jennifer H, Mao, Rong, Pinedo, Kassandra, Roque, Jonasel, Richards, Christopher M, Stabile, Mikayla, Swaminathan, Gayathri, Salagianni, Maria L, Triantafyllia, Vasiliki, Bertrams, Wilhelm, Blish, Catherine A, Carette, Jan E, Frankovich, Jennifer, Meffre, Eric, Nadeau, Kari Christine, Singh, Upinder, Wang, Taia T, Luning Prak, Eline T, Herold, Susanne, Andreakos, Evangelos, Schmeck, Bernd, Skevaki, Chrysanthi, Rogers, Angela J, Utz, Paul J

“…The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non-SARS-CoV-2…”
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