Search Results - "Lulla, Rishi R"

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Improved neuropsychological outcomes following proton therapy relative to X-ray therapy for pediatric brain tumor patients by Gross, Jeffrey P, Powell, Stephanie, Zelko, Frank, Hartsell, William, Goldman, Stewart, Fangusaro, Jason, Lulla, Rishi R, Smiley, Natasha Pillay, Chang, John Han-Chih, Gondi, Vinai

“…Abstract Background Survivors of pediatric brain tumors are at risk for impaired development in multiple neuropsychological domains. The purpose of this study…”
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Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma by Huang, Tina Y, Piunti, Andrea, Lulla, Rishi R, Qi, Jin, Horbinski, Craig M, Tomita, Tadanori, James, C David, Shilatifard, Ali, Saratsis, Amanda M

“…Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise…”
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Identification of microRNAs as potential prognostic markers in ependymoma by Costa, Fabricio F, Bischof, Jared M, Vanin, Elio F, Lulla, Rishi R, Wang, Min, Sredni, Simone T, Rajaram, Veena, Bonaldo, Maria de Fátima, Wang, Deli, Goldman, Stewart, Tomita, Tadanori, Soares, Marcelo B

“…We have examined expression of microRNAs (miRNAs) in ependymomas to identify molecular markers of value for clinical management. miRNAs are non-coding RNAs…”
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Mutations in chromatin machinery and pediatric high-grade glioma by Lulla, Rishi R, Saratsis, Amanda Muhs, Hashizume, Rintaro

“…Pediatric central nervous system tumors are the most common solid tumor of childhood. Of these, approximately one-third are gliomas that exhibit diverse…”
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Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma by Mueller, Sabine, Taitt, Jared M, Villanueva-Meyer, Javier E, Bonner, Erin R, Nejo, Takahide, Lulla, Rishi R, Goldman, Stewart, Banerjee, Anu, Chi, Susan N, Whipple, Nicholas S, Crawford, John R, Gauvain, Karen, Nazemi, Kellie J, Watchmaker, Payal B, Almeida, Neil D, Okada, Kaori, Salazar, Andres M, Gilbert, Ryan D, Nazarian, Javad, Molinaro, Annette M, Butterfield, Lisa H, Prados, Michael D, Okada, Hideho

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Identification of Differentially Expressed MicroRNAs in Osteosarcoma by Lulla, Rishi R., Costa, Fabricio F., Bischof, Jared M., Chou, Pauline M., Bonaldo, Maria de Fatima, Vanin, Elio F., Soares, Marcelo B.

“…A limited number of reports have investigated the role of microRNAs in osteosarcoma. In this study, we performed miRNA expression profiling of osteosarcoma…”
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A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells by Malchenko, Sergey, Sredni, Simone Treiger, Hashimoto, Hitoshi, Kasai, Atsushi, Nagayasu, Kazuki, Xie, Jianping, Margaryan, Naira V, Seiriki, Kaoru, Lulla, Rishi R, Seftor, Richard E B, Pachman, Lauren M, Meltzer, Herbert Y, Hendrix, Mary J C, Soares, Marcelo B

“…There is growing evidence and a consensus in the field that most pediatric brain tumors originate from stem cells, of which radial glial cells constitute a…”
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Imaging findings of anaplastic astrocytoma in a child with maple syrup urine disease: a case report by Aw-Zoretic, Jessie, Wadhwani, Nitin R., Rishi, Lulla R., Ryan, Maura E.

“…Maple syrup urine disease (MSUD) is an inborn error of branched-chain amino acid metabolism, which usually presents in childhood with encephalopathy due to…”
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Activating BRAF G469A Missense Mutation in a Pediatric Patient With High-Grade Glioma by Kronish, Adam, DeNardo, Bradley, Kanach, Colin, Lulla, Rishi R

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Mass cytometry detects H3.3K27M-specific vaccine responses in diffuse midline glioma by Mueller, Sabine, Taitt, Jared M, Villanueva-Meyer, Javier E, Bonner, Erin R, Nejo, Takahide, Lulla, Rishi R, Goldman, Stewart, Banerjee, Anu, Chi, Susan N, Whipple, Nicholas S, Crawford, John R, Gauvain, Karen, Nazemi, Kellie J, Watchmaker, Payal B, Almeida, Neil D, Okada, Kaori, Salazar, Andres M, Gilbert, Ryan D, Nazarian, Javad, Molinaro, Annette M, Butterfield, Lisa H, Prados, Michael D, Okada, Hideho

“…BACKGROUNDPatients with diffuse midline gliomas (DMGs), including diffuse intrinsic pontine glioma (DIPG), have dismal outcomes. We previously described the…”
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Phase I trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study by Lulla, Rishi R, Goldman, Stewart, Yamada, Tohru, Beattie, Craig W, Bressler, Linda, Pacini, Michael, Pollack, Ian F, Fisher, Paul Graham, Packer, Roger J, Dunkel, Ira J, Dhall, Girish, Wu, Shengjie, Onar, Arzu, Boyett, James M, Fouladi, Maryam

“…p53 is a promising target in human cancer. p28 is a cell-penetrating peptide that preferentially enters cancer cells and binds to both wild-type and mutant p53…”
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Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth by Hashizume, Rintaro, Zhang, Ali, Mueller, Sabine, Prados, Michael D, Lulla, Rishi R, Goldman, Stewart, Saratsis, Amanda M, Mazar, Andrew P, Stegh, Alexander H, Cheng, Shi-Yuan, Horbinski, Craig, Haas-Kogan, Daphne A, Sarkaria, Jann N, Waldman, Todd, James, C David

“…Radiation therapy is the most commonly used postsurgical treatment for primary malignant brain tumors. Consequently, investigating the efficacy of…”
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The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science by Lilly, Jena V., Rokita, Jo Lynne, Mason, Jennifer L., Patton, Tatiana, Stefankiewiz, Stephanie, Higgins, David, Trooskin, Gerri, Larouci, Carina A., Arya, Kamnaa, Appert, Elizabeth, Heath, Allison P., Zhu, Yuankun, Brown, Miguel A., Zhang, Bo, Farrow, Bailey K., Robins, Shannon, Morgan, Allison M., Nguyen, Thinh Q., Frenkel, Elizabeth, Lehmann, Kaitlin, Drake, Emily, Sullivan, Catherine, Plisiewicz, Alexa, Coleman, Noel, Patterson, Luke, Koptyra, Mateusz, Helili, Zeinab, Van Kuren, Nicholas, Young, Nathan, Kim, Meen Chul, Friedman, Christopher, Lubneuski, Alex, Blackden, Christopher, Williams, Marti, Baubet, Valerie, Tauhid, Lamiya, Galanaugh, Jamie, Boucher, Katie, Ijaz, Heba, Cole, Kristina A., Choudhari, Namrata, Santi, Mariarita, Moulder, Robert W., Waller, Jonathan, Rife, Whitney, Diskin, Sharon J., Mateos, Marion, Parsons, Donald W., Pollack, Ian F., Goldman, Stewart, Leary, Sarah, Caporalini, Chiara, Buccoliero, Anna Maria, Scagnet, Mirko, Haussler, David, Hanson, Derek, Firestein, Ron, Cain, Jason, Phillips, Joanna J., Gupta, Nalin, Mueller, Sabine, Grant, Gerald, Monje-Deisseroth, Michelle, Partap, Sonia, Greenfield, Jeffrey P., Hashizume, Rintaro, Smith, Amy, Zhu, Shida, Johnston, James M., Fangusaro, Jason R., Miller, Matthew, Wood, Matthew D., Gardner, Sharon, Carter, Claire L., Prolo, Laura M., Pisapia, Jared, Pehlivan, Katherine, Franson, Andrea, Niazi, Toba, Rubin, Josh, Abdelbaki, Mohamed, Ziegler, David S., Lindsay, Holly B., Stucklin, Ana Guerreiro, Gerber, Nicolas, Vaske, Olena M., Quinsey, Carolyn, Rood, Brian R., Nazarian, Javad, Raabe, Eric, Jackson, Eric M., Stapleton, Stacie, Lober, Robert M., Kram, David E., Koschmann, Carl, Storm, Phillip B., Lulla, Rishi R., Prados, Michael, Resnick, Adam C., Waanders, Angela J.

“…Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential…”
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Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma by Dobson, Tara H W, Tao, Rong-Hua, Swaminathan, Jyothishmathi, Maegawa, Shinji, Shaik, Shavali, Bravo-Alegria, Javiera, Sharma, Ajay, Kennis, Bridget, Yang, Yanwen, Callegari, Keri, Haltom, Amanda R, Taylor, Pete, Kogiso, Mari, Qi, Lin, Khatua, Soumen, Goldman, Stewart, Lulla, Rishi R, Fangusaro, Jason, MacDonald, Tobey J, Li, Xiao-Nan, Hawkins, Cynthia, Rajaram, Veena, Gopalakrishnan, Vidya

“…In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH)…”
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Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells by Eckerdt, Frank, Beauchamp, Elspeth, Bell, Jonathan, Iqbal, Asneha, Su, Bing, Fukunaga, Rikiro, Lulla, Rishi R, Goldman, Stewart, Platanias, Leonidas C

“…The mTOR pathway controls mRNA translation of mitogenic proteins and is a central regulator of metabolism in malignant cells. Development of malignant cell…”
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Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition by Iqbal, Asneha, Eckerdt, Frank, Bell, Jonathan, Nakano, Ichiro, Giles, Francis J, Cheng, Shi-Yuan, Lulla, Rishi R, Goldman, Stewart, Platanias, Leonidas C

“…The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism. In glioblastoma (GBM) cell…”
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REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature by Shaik, Shavali, Kennis, Bridget, Maegawa, Shinji, Schadler, Keri, Yanwen, Yang, Callegari, Keri, Lulla, Rishi R, Goldman, Stewart, Nazarian, Javad, Rajaram, Veena, Fangusaro, Jason, Gopalakrishnan, Vidya

“…Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive glial tumor that occurs in children. The extremely poor median and 5-year survival in children…”
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Potent preclinical sensitivity to imipridone-based combination therapies in oncohistone H3K27M-mutant diffuse intrinsic pontine glioma is associated with induction of the integrated stress response, TRAIL death receptor DR5, reduced ClpX and apoptosis by Borsuk, Robyn, Zhou, Lanlan, Chang, Wen-I, Zhang, Yiqun, Sharma, Aditi, Prabhu, Varun V, Tapinos, Nikos, Lulla, Rishi R, El-Deiry, Wafik S

“…The H3K27M oncohistone mutation, identified in approximately 80% of diffuse intrinsic pontine gliomas (DIPG), is a potential target for therapy. Imipridone…”
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Primary Central Nervous System Malignant Melanoma in Children: A Case Series and Review of the Literature by Choi, Daniel K, Pillay-Smiley, Natasha, Marzec, Sarah, Wadhwani, Nitin R, DiPatri, Arthur J, Tomita, Tadanori, Lulla, Rishi R

“…We describe 2 cases of rapidly progressive primary central nervous system malignant melanoma, and summarize 18 previously reported cases of this extremely rare…”
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