Search Results - "Lull, J M"

High yield expression of human BACE constructs in Eschericia coli for refolding, purification, and high resolution diffracting crystal forms by Tomasselli, A G, Paddock, D J, Emmons, T L, Mildner, A M, Leone, J W, Lull, J M, Cialdella, J I, Prince, D B, Fischer, H D, Heinrikson, R L, Benson, T E

“…BACE (beta-site APP cleaving enzyme) or beta-secretase, the enzyme responsible for processing APP to give the N-terminal portion of the Abeta peptide, is a…”
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Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli by Emmons, T L, Mildner, A M, Lull, J M, Leone, J W, Fischer, H D, Heinrikson, R L, Tomasselli, A G

“…Evidence for a key role of beta-amyloid (Abeta) in Alzheimer's disease has led to considerable interest in potential therapeutic strategies targeting enzymes…”
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Employing a superior BACE1 cleavage sequence to probe cellular APP processing by Tomasselli, Alfredo G., Qahwash, Isam, Emmons, Thomas L., Lu, Yifeng, Leone, Joseph W., Lull, June M., Fok, Kam F., Bannow, Carol A., Smith, Clark W., Bienkowski, Michael J., Heinrikson, Robert L., Yan, Riqiang

“…The involvement of β‐secretase (BACE1; β‐site APP‐cleaving enzyme) in producing the β‐amyloid component of plaques found in the brains of Alzheimer's patients,…”
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The HIV-1 Protease as Enzyme and Substrate: Mutagenesis of Autolysis Sites and Generation of a Stable Mutant with Retained Kinetic Properties by Mildner, Ana M, Rothrock, Donna J, Leone, Joseph W, Bannow, Carol A, Lull, June M, Reardon, Ilene M, Sarcich, Jean L, Howe, W. Jeffrey, Tomich, Che-Shen C

“…Site-directed mutagenesis of autolysis sites in the human immunodeficiency virus type 1 (HIV-1) protease was applied in an analysis of enzyme specificity; the…”
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Efficacy and safety of paliperidone palmitate in adult patients with acutely symptomatic schizophrenia: a randomized, double-blind, placebo-controlled, dose-response study by Gopal, Srihari, Hough, David W, Xu, Haiyan, Lull, Julia M, Gassmann-Mayer, Cristiana, Remmerie, Bart M, Eerdekens, Marielle H, Brown, David W

“…This 13-week, double-blind study evaluated the efficacy and safety of the atypical antipsychotic paliperidone palmitate (recently approved in the United…”
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Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies by Hui, J O, Tomasselli, A G, Reardon, I M, Lull, J M, Brunner, D P, Tomich, C S, Heinrikson, R L

“…The protease encoded by the human immunodeficiency virus type 1 (HIV-1) was engineered in Escherichia coli as a construct in which the natural 99-residue…”
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Use of the multiple sclerosis functional composite as an outcome measure in a phase 3 clinical trial by Cohen, J A, Cutter, G R, Fischer, J S, Goodman, A D, Heidenreich, F R, Jak, A J, Kniker, J E, Kooijmans, M F, Lull, J M, Sandrock, A W, Simon, J H, Simonian, N A, Whitaker, J N

“…The Multiple Sclerosis Functional Composite (MSFC) is a multidimensional clinical outcome measure that includes quantitative tests of leg function/ambulation…”
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Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe by Colca, Jerry R, McDonald, William G, Waldon, Daniel J, Leone, Joseph W, Lull, June M, Bannow, Carol A, Lund, Eric T, Mathews, W Rodney

“…Thiazolidinediones address underlying causes of type 2 diabetes, although their mechanism of action is not clearly understood. The compounds are thought to…”
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Analysis of carrier ampholytes by ion exchange chromatography by Brown, R K, Lull, J M, Lowenkron, S, Bagshaw, J C, Vinogradov, S N

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Recombinant human cytomegalovirus protease with a C-terminal (His)6 extension: purification, autocatalytic release of the mature enzyme, and biochemical characterization by Tomasselli, A G, Paddock, D J, Curry, K A, Garlick, R L, Leone, J W, Lull, J M, Mutchler, V T, Baker, C A, Cavey, G S, Mathews, W R, Shelly, J A, Finzel, B C, Baldwin, E T, Wells, P A, Tomich, C S

“…Human cytomegalovirus protease (CMV PR) is a target for the development of antiviral therapeutics. To obtain large amounts of native protease, a 268-amino-acid…”
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