Search Results - "Luli, Saimir"

Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging by Leslie, Jack, Robinson, Stuart M., Oakley, Fiona, Luli, Saimir

“…Advances in fluorescence imaging coupled with the generation of near infrared probes have significantly improved the capabilities of non-invasive, real-time…”
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Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling by Tual-Chalot, Simon, Garcia-Collado, Maria, Redgrave, Rachael E., Singh, Esha, Davison, Benjamin, Park, Catherine, Lin, Hua, Luli, Saimir, Jin, Yi, Wang, Yixin, Lawrie, Allan, Jakobsson, Lars, Arthur, Helen M.

“…ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and is strongly expressed in endothelial cells. Mutations in lead to the inherited…”
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Synthesis and preclinical evaluation of a 89Zr-labelled human single chain antibody for non-invasive detection of hepatic myofibroblasts in acute liver injury by Pringle, Toni A., Ramon-Gil, Erik, Leslie, Jack, Oakley, Fiona, Wright, Matthew C., Knight, James C., Luli, Saimir

“…Synaptophysin is expressed on fibrogenic hepatic myofibroblasts. C1–3 is a single chain human antibody (scAb) that binds specifically to synaptophysin on…”
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A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A by Zeybel, Müjdat, Luli, Saimir, Sabater, Laura, Hardy, Timothy, Oakley, Fiona, Leslie, Jack, Page, Agata, Moran Salvador, Eva, Sharkey, Victoria, Tsukamoto, Hidekazu, Chu, David C.K., Singh, Uma Sharan, Ponzoni, Mirco, Perri, Patrizia, Di Paolo, Daniela, Mendivil, Edgar J., Mann, Jelena, Mann, Derek A.

“…The progression of fibrosis in chronic liver disease is dependent upon hepatic stellate cells (HSCs) transdifferentiating to a myofibroblast-like phenotype…”
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Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease by Fox, Christopher, Cocchiaro, Pasquale, Oakley, Fiona, Howarth, Rachel, Callaghan, Krystena, Leslie, Jack, Luli, Saimir, Wood, Katrina M., Genovese, Federica, Sheerin, Neil S., Moles, Anna

“…During chronic kidney disease (CKD) there is a dysregulation of extracellular matrix (ECM) homeostasis leading to renal fibrosis. Lysosomal proteases such as…”
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How Do Roots Interact with Layered Soils? by Kemp, Nina, Angelidakis, Vasileios, Luli, Saimir, Nadimi, Sadegh

“…Vegetation alters soil fabric by providing biological reinforcement and enhancing the overall mechanical behaviour of slopes, thereby controlling shallow mass…”
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Imaging the root–rhizosphere interface using micro computed tomography: quantifying void ratio and root volume ratio profiles by Lascurain, Tomás, Angelidakis, Vasileios, Luli, Saimir, Nadimi, Sadegh

“…Root growth alters soil fabric and consequently its mechanical and physical properties. Recent studies show that roots induce compaction of soil in their…”
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Synthesis and In Vitro Evaluation of a HER2-Specific ImmunoSCIFI Probe by Gristwood, Katie, Luli, Saimir, Rankin, Kenneth S., Knight, James C.

“…Secondary Cerenkov-induced fluorescence imaging (SCIFI) is an emerging biomedical optical imaging modality that leverages Cerenkov luminescence, primarily…”
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Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice by Kamala, Ola, Malik, Talat H, Hallam, Thomas M, Cox, Thomas E, Yang, Yi, Vyas, Falguni, Luli, Saimir, Connelly, Chloe, Gibson, Beth, Smith-Jackson, Kate, Denton, Harriet, Pappworth, Isabel Y, Huang, Lei, Kavanagh, David, Pickering, Matthew C, Marchbank, Kevin J

“…C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH)…”
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Evoked compound action potential (ECAP)-controlled closed-loop spinal cord stimulation in an experimental model of neuropathic pain in rats by Versantvoort, Eline M, Dietz, Birte E, Mugan, Dave, Vuong, Quoc C, Luli, Saimir, Obara, Ilona

“…Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters. The evoked compound…”
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FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis by Leslie, Jack, Millar, Ben Jm, Del Carpio Pons, Alicia, Burgoyne, Rachel A, Frost, Joseph D, Barksby, Ben S, Luli, Saimir, Scott, Jon, Simpson, A John, Gauldie, Jack, Murray, Lynne A, Finch, Donna K, Carruthers, Alan M, Ferguson, John, Sleeman, Matthew A, Rider, David, Howarth, Rachel, Fox, Christopher, Oakley, Fiona, Fisher, Andrew J, Mann, Derek A, Borthwick, Lee A

“…Neutrophils are the most abundant inflammatory cells at the earliest stages of wound healing and play important roles in wound repair and fibrosis. Formyl…”
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Inhibition of RelA‐Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response by Moles, Anna, Sanchez, Ana M., Banks, Paul S., Murphy, Lindsay B., Luli, Saimir, Borthwick, Lee, Fisher, Andrew, O'Reilly, Steven, van Laar, Jacob M., White, Steven A., Perkins, Neil D., Burt, Alastair D., Mann, Derek A., Oakley, Fiona

“…Phosphorylation of the RelA subunit at serine 536 (RelA‐P‐Ser536) is important for hepatic myofibroblast survival and is mechanistically implicated in liver…”
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P-218 - The development of a dual-modality (PET/NIR) radioimmunoconjugate for image-guided sarcoma surgery by Pringle, Toni, Knight, James, Chan, Corey, Blair, Helen, Luli, Saimir, Rankin, Kenneth

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The development of a dual-modality (PET/NIR) radioimmunoconjugate for image-guided sarcoma surgery by Pringle, Toni, Knight, James, Chan, Corey, Blair, Helen, Luli, Saimir, Rankin, Kenneth

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Neutrophil degranulation and ageing as potential therapeutic targets in hepatocellular carcinoma? by Geh, Daniel, Gil, Erik Ramon, Laszczewska, Maja, Collins, Amy, Luli, Saimir, Cameron, Rainie, Oakley, Fiona, Reeves, Helen Louise, Mann, Derek A, Leslie, Jack

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SAT-239 - Neutrophil degranulation and ageing as potential therapeutic targets in hepatocellular carcinoma? by Geh, Daniel, Gil, Erik Ramon, Laszczewska, Maja, Collins, Amy, Luli, Saimir, Cameron, Rainie, Oakley, Fiona, Reeves, Helen Louise, Mann, Derek A, Leslie, Jack

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SAT-234 - Immunotherapy resistance in NASH-HCC is driven by the dysfunctional liver microenvironment of NASH by Geh, Daniel, Gil, Erik Ramon, Laszczewska, Maja, Collins, Amy, Luli, Saimir, Cameron, Rainie, Oakley, Fiona, Leslie, Jack, Reeves, Helen Louise, Mann, Derek A

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Immunotherapy resistance in NASH-HCC is driven by the dysfunctional liver microenvironment of NASH by Geh, Daniel, Gil, Erik Ramon, Laszczewska, Maja, Collins, Amy, Luli, Saimir, Cameron, Rainie, Oakley, Fiona, Leslie, Jack, Reeves, Helen Louise, Mann, Derek A

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Assessing the potential application of bacteria-based self-healing cementitious materials for enhancing durability of wastewater treatment infrastructure by Bagga, Manpreet, Justo-Reinoso, Ismael, Hamley-Bennett, Charlotte, Merces, George, Luli, Saimir, Akono, Ange Therese, Masoero, Enrico, Paine, Kevin, Gebhard, Susanne, Ofiţeru, Irina D.

“…Wastewater treatment plants (WWTPs) around the world are mainly built using concrete. The continuous exposure to wastewater affects the durability of concrete…”
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Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells by Moran-Salvador, Eva, Garcia-Macia, Marina, Sivaharan, Ashwin, Sabater, Laura, Zaki, Marco Y.W., Oakley, Fiona, Knox, Amber, Page, Agata, Luli, Saimir, Mann, Jelena, Mann, Derek A.

“…Methyl-CpG binding protein 2, MECP2, which binds to methylated regions of DNA to regulate transcription, is expressed by hepatic stellate cells (HSCs) and is…”
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