Antiurolithiatic effect of lithocare against ethylene glycol-induced urolithiasis in Wistar rats

Antiurolithiatic effect of lithocare against ethylene glycol-induced urolithiasis in Wistar rats

This study is aimed to investigate the protective effect of Lithocare (LC) (a polyherbal formulation) against ethylene glycol (EG) induced urolithiasis in Wistar rats. The protective effect of LC (400 and 800 mg/kg) was evaluated using EG-induced urolithiasis in rats. Administration of EG in drinkin...

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Bibliographic Details
Published in:Indian journal of pharmacology Vol. 48; no. 1; pp. 78 - 82
Main Authors: Lulat, Sumaiya I, Yadav, Yogesh Chand, Balaraman, R, Maheshwari, Rajesh
Format: Journal Article
Language:English
Published: India Medknow Publications and Media Pvt. Ltd 01-01-2016
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects:
Administration, Oral
Animals
Antifreeze solutions
Dose-Response Relationship, Drug
Ethylene Glycol - toxicity
Ethylene glycols
Health aspects
Herbal Medicine
Kidneys
Male
Medicinal plants
Physiological aspects
Rats
Rats, Wistar
Rodents
Short Communication
Studies
Urinary stones
Urolithiasis - chemically induced
Urolithiasis - prevention & control
lithocare
urolithiasis
Ethylene glycol
Wistar rats
polyherbal formulation
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Summary:This study is aimed to investigate the protective effect of Lithocare (LC) (a polyherbal formulation) against ethylene glycol (EG) induced urolithiasis in Wistar rats. The protective effect of LC (400 and 800 mg/kg) was evaluated using EG-induced urolithiasis in rats. Administration of EG in drinking water resulted in hyperoxaluria, hypocalcemia as well as an increased renal excretion of phosphate. Supplementation with LC significantly reduced the urinary calcium, oxalate, and phosphate excretion dose-dependently. There was a significant reduction in the levels of calcium, oxalate as well as a number of calcium oxalate crystals deposits in the kidney tissue of rats administered with LC in EG-treated rats. There was a significant reduction in creatinine, urea, uric acid, and blood urea nitrogen when LC was administered in EG-treated rats. From this study, it was concluded that the supplementation of LC protected EG-induced urolithiasis as it reduced the growth of urinary stones. The mechanism underlying this effect might be due to its antioxidant, diuretic, and reduction in stone-forming constituents.
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ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.174564