Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry

Background The ESPN/ERA–EDTA Registry collects data on European children with end-stage renal disease receiving renal replacement therapy (RRT) who are listed on national and regional renal registries in Europe. In this paper we report on the analysis of demographic data collected from 2009 to 2011....

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Published in:	Pediatric nephrology (Berlin, West) Vol. 29; no. 12; pp. 2403 - 2410
Main Authors:	Chesnaye, Nicholas, Bonthuis, Marjolein, Schaefer, Franz, Groothoff, Jaap W., Verrina, Enrico, Heaf, James G., Jankauskiene, Augustina, Lukosiene, Viktorija, Molchanova, Elena A., Mota, Conceicao, Peco-Antić, Amira, Ratsch, Ilse-Maria, Bjerre, Anna, Roussinov, Dimitar L., Sukalo, Alexander, Topaloglu, Rezan, Van Hoeck, Koen, Zagozdzon, Ilona, Jager, Kitty J., Van Stralen, Karlijn J.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2014 Springer Springer Nature B.V
Subjects:	Adolescent Age groups Care and treatment Child Child, Preschool Chronic kidney failure Demographic aspects Demographics Europe - epidemiology Female Hemodialysis Hospitals Humans Incidence Infant Infant, Newborn Kidney diseases Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - therapy Kidney Transplantation - mortality Kidney Transplantation - statistics & numerical data Male Medicine Medicine & Public Health Nephrology Original Article Pediatrics Peritoneal dialysis Population Prevalence Registries Renal replacement therapy Renal Replacement Therapy - mortality Renal Replacement Therapy - statistics & numerical data Transplants & implants Urology Young Adult Europe Italy Germany Montenegro Prevalence Chronic kidney failure Europe Renal replacement therapy Survival Paediatrics Incidence
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Summary:	Background The ESPN/ERA–EDTA Registry collects data on European children with end-stage renal disease receiving renal replacement therapy (RRT) who are listed on national and regional renal registries in Europe. In this paper we report on the analysis of demographic data collected from 2009 to 2011. Methods Data on primary renal disease, incidence, prevalence, 4-year survival, transplantation rate and causes of death in paediatric patients receiving RRT were extracted from the ESPN/ERA–EDTA Registry for 37 European countries. Results The incidence of RRT in paediatric patients in Europe during the study period was 5.5 cases per million age-related population (pmarp) in patients aged 0–14 years and varied markedly between countries (interquartile range 3.4–7.0 years). The prevalence of RRT was 27.9 pmarp and increased with age, with 67 % of prevalent patients living with a functioning graft. The probability of receiving a transplant within 4 years was 76.9 % and was lowest in patients aged 0–4 years (68.9 %). Mortality in paediatric patients treated with RRT was 55-fold higher than that of the general EU paediatric population. Overall survival at 4 years was 93.7 %, with the poorest survival in patients aged 0–4 years and in patients starting on dialysis. Infections (19.9 %) were the primary cause of death in European paediatric RRT patients. Conclusion Considerable variation exists in the current demographics of children treated with RRT across Europe.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s00467-014-2884-6