Search Results - "Lukiw, W"

Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis by Alexandrov, P.N., Hill, J.M., Zhao, Y., Bond, T., Taylor, C.M., Percy, M.E., Li, W., Lukiw, W.J.

“…Gram-negative bacteria of the human gastrointestinal (GI) tract microbiome: (i) are capable of generating a broad-spectrum of highly neurotoxic,…”
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Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation by Pogue, A.I., Cui, J.G., Li, Y.Y., Zhao, Y., Culicchia, F., Lukiw, W.J.

“…Micro RNAs (miRNAs) are post-transcriptional modulators of gene expression that regulate the stability and translation of their target messenger RNAs (mRNAs)…”
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Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models by Li, Y.Y., Cui, J.G., Hill, J.M., Bhattacharjee, S., Zhao, Y., Lukiw, W.J.

“…▶ Micro-RNA 146a (miRNA-146a) is a mouse and human brain-enriched miRNA implicated in the innate immune response and inflammatory signaling. ▶ miRNA-146a was…”
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A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease by Lukiw, Walter J, Cui, Jian-Guo, Marcheselli, Victor L, Bodker, Merete, Botkjaer, Anja, Gotlinger, Katherine, Serhan, Charles N, Bazan, Nicolas G

“…Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stressed…”
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Early insight into the potential contribution of aluminum to neurodegeneration - A tribute to the research work of Robert D. Terry, Igor Klatzo, Henryk M. Wisniewski and Donald R.C. Mclachlan by Hill, J.M., Percy, M.E., Lukiw, W.J.

“…The first successful attempt to obtain purified aluminum metal was accomplished by the Danish physicist and chemist Hans Christian Orsted in 1824, however it…”
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Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice by Pogue, AI, Dua, P, Hill, JM, Lukiw, WJ

“…At least 57 murine transgenic models for Alzheimer's disease (Tg-AD) have been developed to overexpress the 42 amino acid amyloid-beta (Aβ42) peptide in the…”
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Biological basis for amyloidogenesis in Alzheimer’S disease by Andreeva, T. V., Lukiw, W. J., Rogaev, E. I.

“…Certain cellular proteins normally soluble in the living organism under certain conditions form aggregates with a specific cross-β sheet structure called…”
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Role of microRNA (miRNA) and Viroids in Lethal Diseases of Plants and Animals. Potential Contribution to Human Neurodegenerative Disorders by Cong, L., Zhao, Y., Pogue, A. I., Lukiw, W. J.

“…Both plants and animals have adopted a common strategy of using ~18–25-nucleotide small non-coding RNAs (sncRNAs), known as microRNAs (miRNAs), to transmit…”
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Micro-RNA-128 (miRNA-128) down-regulation in glioblastoma targets ARP5 (ANGPTL6), Bmi-1 and E2F-3a, key regulators of brain cell proliferation by Cui, J. G., Zhao, Y., Sethi, P., Li, Y. Y., Mahta, A., Culicchia, F., Lukiw, W. J.

“…High density micro-RNA (miRNA) arrays, fluorescent-reporter miRNA assay and Northern miRNA dot-blot analysis show that a brain-enriched miRNA-128 is…”
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Aluminum, the genetic apparatus of the human CNS and Alzheimer's disease (AD) by Pogue, A.I., Lukiw, W.J.

“…The genomes of eukaryotes orchestrate their expression to ensure an effective, homeostatic and functional gene signaling program, and this includes…”
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Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt-Jakob Disease (sCJD) and Gerstmann-Straussler-Scheinker (GSS) Syndrome by Lukiw, W. J., Dua, P., Pogue, A. I., Eicken, C., Hill, J. M.

“…A mouse- and human-brain-abundant, nuclear factor (NF)-кB-regulated, micro RNA-146a (miRNA-146a) is an important modulator of the innate immune response and…”
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Survival signalling in Alzheimer's disease by Lukiw, W J, Bazan, N G

“…Significant advancements in our understanding of cell-survival signalling in AD (Alzheimer's disease) stem from recent investigations into the metabolism,…”
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Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM) by Lukiw, W. J., Cui, J. G., Li, Y. Y., Culicchia, F.

“…Glioblastoma multiforme (GBM) represents a class of malignant gliomas which rapidly proliferate, invade and destroy surrounding brain tissues. This study…”
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Gliomas and seizures by Prakash, O, Lukiw, W.J, Peruzzi, F, Reiss, K, Musto, A.E

“…Abstract Glial neoplasms account for nearly 50% of all adult primary brain tumors. They originate from glial cells in the brain and/or spinal cord and include…”
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Gene expression profiling in fetal, aged, and Alzheimer hippocampus: a continuum of stress-related signaling by Lukiw, Walter J

“…While specific components of normal brain aging and Alzheimer's disease (AD) appear to be genetically determined, it is not well understood whether AD is due…”
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Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression by Marcheselli, Victor L., Hong, Song, Lukiw, Walter J., Tian, Xiao Hua, Gronert, Karsten, Musto, Alberto, Hardy, Mattie, Gimenez, Juan M., Chiang, Nan, Serhan, Charles N., Bazan, Nicolas G.

“…Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid released from membrane phospholipids during brain ischemia is a major…”
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Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling by Colangelo, Vittorio, Schurr, Jill, Ball, Melvyn J., Pelaez, Ricardo Palacios, Bazan, Nicolas G., Lukiw, Walter J.

“…Alterations in transcription, RNA editing, translation, protein processing, and clearance are a consistent feature of Alzheimer's disease (AD) brain. To extend…”
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Cyclooxygenase-2 and Presenilin-1 Gene Expression Induced by Interleukin-1 beta and Amyloid beta 42 Peptide Is Potentiated by Hypoxia in Primary Human Neural Cells by Bazan, NG, Lukiw, W J

“…Lipid messengers and amyloid beta (A beta ) peptides generated by cyclooxygenase-2 (COX-2) and presenilin-1 (PS1) mediate pro-inflammatory signaling and neural…”
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Regulatory region variability in the human presenilin-2 (PSEN2) gene: Potential contribution to the gene activity and risk for AD by RIAZANSKAIA, N, LUKIW, W. J, GRIGORENKO, A, KOROVAITSEVA, G, DVORYANCHIKOV, G, MOLIAKA, Y, NICOLAOU, M, FARRER, L, BAZAN, N. G, ROGAEV, E. L

“…We have analyzed the 5'-upstream promoter region of the presenilin 2 gene (PSEN2) for regulatory elements and examined Alzheimer disease (AD) patients and…”
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Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease by ROGAEV, E. I, SHERRINGTON, R, DE JONG, P. J, FRASER, P. E, ROMMENS, J. M, ST GEORGE-HYSLOP, P, WU, C, LEVESQUE, G, LIANG, Y, ROGAEVA, E. A, IKEDA, M, HOLMAN, K, LIN, C, LUKIW, W. J

“…Mutations in the human presenilin genes (PSEN1 and PSEN2) are associated with early onset familial Alzheimer disease. The presenilin genes encode integral…”
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