Search Results - "Lukinavičius, Gražvydas"
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Triarylmethane Fluorophores Resistant to Oxidative Photobluing
Published in Journal of the American Chemical Society (16-01-2019)“…Spectral stability of small-molecule fluorescent probes is required for correct interpretation and reproducibility of multicolor fluorescence imaging data, in…”
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2
The Use of Hoechst Dyes for DNA Staining and beyond
Published in Chemosensors (01-06-2018)“…Hoechst dyes are among the most popular fluorophores used to stain DNA in living and fixed cells. Moreover, their high affinity and specificity towards DNA…”
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3
SiR–Hoechst is a far-red DNA stain for live-cell nanoscopy
Published in Nature communications (01-10-2015)“…Cell-permeable DNA stains are popular markers in live-cell imaging. Currently used DNA stains for live-cell imaging are either toxic, require illumination with…”
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4
Fluorogenic probes for live-cell imaging of the cytoskeleton
Published in Nature methods (01-07-2014)“…Far-red fluorogenic probes for live-cell imaging of either actin or tubulin are described and used for super-resolution microscopy of various structures in a…”
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Rhodamine-Hoechst positional isomers for highly efficient staining of heterochromatin
Published in Chemical science (Cambridge) (21-02-2019)“…Hoechst conjugates to fluorescent dyes are popular DNA stains for live-cell imaging, but the relationship between their structure and performance remains…”
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A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins
Published in Nature chemistry (01-02-2013)“…The ideal fluorescent probe for bioimaging is bright, absorbs at long wavelengths and can be implemented flexibly in living cells and in vivo . However, the…”
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7
Cell-Permeant Large Stokes Shift Dyes for Transfection-Free Multicolor Nanoscopy
Published in Journal of the American Chemical Society (13-09-2017)“…We designed cell-permeant red-emitting fluorescent dye labels with >140 nm Stokes shifts based on 9-iminoanthrone, 9-imino-10-silaxanthone, and…”
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Mechanism of spindle pole organization and instability in human oocytes
Published in Science (American Association for the Advancement of Science) (11-02-2022)“…Human oocytes are prone to assembling meiotic spindles with unstable poles, which can favor aneuploidy in human eggs. The underlying causes of spindle…”
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Enhancing the biocompatibility of rhodamine fluorescent probes by a neighbouring group effect
Published in Chemical science (Cambridge) (28-07-2020)“…Fluorescence microscopy is an essential tool for understanding dynamic processes in living cells and organisms. However, many fluorescent probes for labelling…”
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10
Sequence-specific DNA labelling for fluorescence microscopy
Published in Biosensors & bioelectronics (15-06-2023)“…The preservation of nucleus structure during microscopy imaging is a top priority for understanding chromatin organization, genome dynamics, and gene…”
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Switchable fluorophores for protein labeling in living cells
Published in Current opinion in chemical biology (01-12-2011)“…► The manuscript reviews the use of switchable probes that can be targeted to specific structures in cells. ► Use of photoswitchable fluorophores for…”
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Fluorescence microscopy: strategic blinking
Published in Nature chemistry (01-08-2014)Get full text
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13
Fluorescent dyes and probes for super-resolution microscopy of microtubules and tracheoles in living cells and tissues
Published in Chemical science (Cambridge) (07-04-2018)“…We introduce fluorogenic tubulin probes based on the recently reported fluorescent dyes (510R, 580CP, GeR and SiR) and chemotherapy agents - taxanes…”
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Selective Cross-Linking of Interacting Proteins Using Self-Labeling Tags
Published in Journal of the American Chemical Society (16-12-2009)“…We have designed molecules that permit the selective cross-linking (S-CROSS) of interacting proteins in cell lysates and the sensitive detection of the trapped…”
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15
Selective Chemical Crosslinking Reveals a Cep57-Cep63-Cep152 Centrosomal Complex
Published in Current biology (04-02-2013)“…The centrosome functions as the main microtubule-organizing center of animal cells and is crucial for several fundamental cellular processes [1]. Abnormalities…”
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Fluorescent Probes for Live Cell Imaging
Published in Chemosensors (01-09-2018)“…n/a…”
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Correction to “Triarylmethane Fluorophores Resistant to Oxidative Photobluing”
Published in Journal of the American Chemical Society (27-11-2019)Get full text
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18
Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases
Published in Nature chemical biology (01-01-2006)“…S-Adenosyl-L-methionine (AdoMet) is the major methyl donor for biological methylation reactions catalyzed by methyltransferases. We report the first chemical…”
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Targeted Labeling of DNA by Methyltransferase-Directed Transfer of Activated Groups (mTAG)
Published in Journal of the American Chemical Society (14-03-2007)“…Methyltransferases catalyze highly specific transfers of methyl groups from the ubiquitous cofactor S-adenosyl-l-methionine (AdoMet) to various biopolymers…”
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Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA
Published in Nucleic acids research (01-12-2012)“…DNA methyltransferases catalyse the transfer of a methyl group from the ubiquitous cofactor S-adenosyl-L-methionine (AdoMet) onto specific target sites on DNA…”
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