Electrochemical Biosensor Powered by Pre-concentration: Improved Sensitivity and Selectivity towards Lactate

Electrochemical Biosensor Powered by Pre-concentration: Improved Sensitivity and Selectivity towards Lactate

We report on the flow‐injection (FIA) electrochemical system coupling with ion‐exchange pre‐concentration column. The response of the FIA system is provided by the advanced lactate biosensor based on Prussian Blue as an electrocatalyst. The FIA system powered by pre‐concentration is characterized by...

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Bibliographic Details
Published in:Electroanalysis (New York, N.Y.) Vol. 28; no. 10; pp. 2389 - 2393
Main Authors: Karyakina, E. E., Lukhnovich, A. V., Yashina, E. I., Statkus, M. A., Tsisin, G. I., Karyakin, A. A.
Format: Journal Article
Language:English
Published: Blackwell Publishing Ltd 01-10-2016
Subjects:
Biosensors
Calibration
Coupling
Electrocatalysts
exhaled breath condensate
flow-injection
lactate biosensor
Lactates
pre-concentration
Prussian Blue
Selectivity
Sportsmen
Systems analysis
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Summary:We report on the flow‐injection (FIA) electrochemical system coupling with ion‐exchange pre‐concentration column. The response of the FIA system is provided by the advanced lactate biosensor based on Prussian Blue as an electrocatalyst. The FIA system powered by pre‐concentration is characterized by improved selectivity avoiding influence of non‐anionic interfering compounds. The attractive performance characteristics of the system with pre‐concentration which are advantageous over conventional FIA combined with a similar biosensor are: (i) the 50 times improved sensitivity (7.0 A cm−2 M−1) and (ii) the calibration range shifted by almost two orders of magnitude towards lower analyte concentrations. The developed FIA system was tested for lactate detection in exhaled breath condensate samples collected from pulmonary patients and sportsmen.
Bibliography:ArticleID:ELAN201600232
istex:2FFD82DE060AF27055CFEF1DFDB3568F5DEAABD0
Russian Science Foundation - No. 16-13-00010
ark:/67375/WNG-1MWH9L1H-V
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1040-0397
1521-4109
DOI:10.1002/elan.201600232