Search Results - "Luke L. Lairson"

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic by Chin, Emily N, Yu, Chenguang, Vartabedian, Vincent F, Jia, Ying, Kumar, Manoj, Gamo, Ana M, Vernier, William, Ali, Sabrina H, Kissai, Mildred, Lazar, Daniel C, Nguyen, Nhan, Pereira, Laura E, Benish, Brent, Woods, Ashley K, Joseph, Sean B, Chu, Alan, Johnson, Kristen A, Sander, Philipp N, Martínez-Peña, Francisco, Hampton, Eric N, Young, Travis S, Wolan, Dennis W, Chatterjee, Arnab K, Schultz, Peter G, Petrassi, H Michael, Teijaro, John R, Lairson, Luke L

“…Stimulator of interferon genes (STING) links innate immunity to biological processes ranging from antitumor immunity to microbiome homeostasis. Mechanistic…”
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A regenerative approach to the treatment of multiple sclerosis by Deshmukh, Vishal A., Tardif, Virginie, Lyssiotis, Costas A., Green, Chelsea C., Kerman, Bilal, Kim, Hyung Joon, Padmanabhan, Krishnan, Swoboda, Jonathan G., Ahmad, Insha, Kondo, Toru, Gage, Fred H., Theofilopoulos, Argyrios N., Lawson, Brian R., Schultz, Peter G., Lairson, Luke L.

“…Progressive phases of multiple sclerosis are associated with inhibited differentiation of the progenitor cell population that generates the mature…”
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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers by Mullarky, Edouard, Lucki, Natasha C., Zavareh, Reza Beheshti, Anglin, Justin L., Gomes, Ana P., Nicolay, Brandon N., Wong, Jenny C. Y., Christen, Stefan, Takahashi, Hidenori, Singh, Pradeep K., Blenis, John, Warren, J. David, Fendt, Sarah-Maria, Asara, John M., DeNicola, Gina M., Lyssiotis, Costas A., Lairson, Luke L., Cantley, Lewis C.

“…Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in…”
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Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A by Zhao, Xiaohui, Stein, Kathryn R., Chen, Victor, Griffin, Matthew E., Lairson, Luke L., Hang, Howard C.

“…The microbiota generates diverse metabolites to modulate host physiology and disease, but their protein targets and mechanisms of action have not been fully…”
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Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists by Huffman, Benjamin J., Chen, Shuming, Schwarz, J. Luca, Plata, R. Erik, Chin, Emily N., Lairson, Luke L., Houk, K. N., Shenvi, Ryan A.

“…sp 3 -hybridized attached-rings are common motifs in secondary metabolites and represent tetrahedral equivalents to the biaryl substructures that overpopulate…”
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A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers by Bollong, Michael J., Pietilä, Mika, Pearson, Aaron D., Sarkar, Tapasree Roy, Ahmad, Insha, Soundararajan, Rama, Lyssiotis, Costas A., Mani, Sendurai A., Schultz, Peter G., Lairson, Luke L.

“…Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial–mesenchymal transition, a developmental program that when…”
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Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 by Lyssiotis, Costas A, Foreman, Ruth K, Staerk, Judith, Garcia, Michael, Mathur, Divya, Markoulaki, Styliani, Hanna, Jacob, Lairson, Luke L, Charette, Bradley D, Bouchez, Laure C, Bollong, Michael, Kunick, Conrad, Brinker, Achim, Cho, Charles Y, Schultz, Peter G, Jaenisch, Rudolf

“…Ectopic expression of defined transcription factors can reprogram somatic cells to induced pluripotent stem (iPS) cells, but the utility of iPS cells is…”
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Discovery of Small Molecules for the Reversal of T Cell Exhaustion by Marro, Brett S., Zak, Jaroslav, Zavareh, Reza Beheshti, Teijaro, John R., Lairson, Luke L., Oldstone, Michael B.A.

“…Inhibitory receptors (IRs) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as…”
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A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer by Bollong, Michael J, Yun, Hwayoung, Sherwood, Lance, Woods, Ashley K, Lairson, Luke L, Schultz, Peter G

“…NRF2 serves as the master regulator of oxidative stress resistance in mammalian cells. Although NRF2 activation decreases tumorigenic events in normal cells,…”
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A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer by Lucki, Natasha C., Villa, Genaro R., Vergani, Naja, Bollong, Michael J., Beyer, Brittney A., Lee, Jae Wook, Anglin, Justin L., Spangenberg, Stephan H., Chin, Emily N., Sharma, Amandeep, Johnson, Kevin, Sander, Philipp N., Gordon, Perry, Skirboll, Stephen L., Wurdak, Heiko, Schultz, Peter G., Mischel, Paul S., Lairson, Luke L.

“…Glioblastoma multiforme (GBM; grade IV astrocytoma) is the most prevalent and aggressive form of primary brain cancer. A subpopulation of multipotent cells…”
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Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas by Kuburich, Nick A., den Hollander, Petra, Castaneda, Maria, Pietilä, Mika, Tang, Ximing, Batra, Harsh, Martínez-Peña, Francisco, Visal, Tanvi H., Zhou, Tieling, Demestichas, Breanna R., Dontula, Ritesh V., Liu, Jojo Y., Maddela, Joanna Joyce, Padmanabhan, Reethi S., Phi, Lan Thi Hanh, Rosolen, Matthew J., Sabapathy, Thiru, Kumar, Dhiraj, Giancotti, Filippo G., Lairson, Luke L., Raso, Maria Gabriela, Soundararajan, Rama, Mani, Sendurai A.

“…Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and stem-like attributes, facilitating metastasis, a leading cause of…”
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Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics by Lum, Kenneth M, Sato, Yoshiaki, Beyer, Brittney A, Plaisted, Warren C, Anglin, Justin L, Lairson, Luke L, Cravatt, Benjamin F

“…Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes…”
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High-throughput screening methodology for the directed evolution of glycosyltransferases by Withers, Stephen G, Aharoni, Amir, Thieme, Karena, Chiu, Cecilia P C, Buchini, Sabrina, Lairson, Luke L, Chen, Hongming, Strynadka, Natalie C J, Wakarchuk, Warren W

“…Engineering of glycosyltransferases (GTs) with desired substrate specificity for the synthesis of new oligosaccharides holds great potential for the…”
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small molecule accelerates neuronal differentiation in the adult rat by Wurdak, Heiko, Zhu, Shoutian, Min, Kyung Hoon, Aimone, Lindsey, Lairson, Luke L, Watson, James, Chopiuk, Gregory, Demas, James, Charette, Bradley, Weerapana, Eranthie, Cravatt, Benjamin F, Cline, Hollis T, Peters, Eric C, Zhang, Jay, Walker, John R, Wu, Chunlei, Chang, Jonathan, Tuntland, Tove, Cho, Charles Y, Schultz, Peter G

“…Adult neurogenesis occurs in mammals and provides a mechanism for continuous neural plasticity in the brain. However, little is known about the molecular…”
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Editorial overview: Modality, discovery, and class by Lairson, Luke L.

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Protocol for high-throughput compound screening using flow cytometry in THP-1 cells by Spangenberg, Stephan H., Zavareh, Reza Beheshti, Lairson, Luke L.

“…Flow cytometry is a valuable method for analyzing protein expressions at the single cell level but can be difficult to apply to large numbers of samples. This…”
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Targeting STING to promote antitumor immunity by Chin, Emily N., Sulpizio, Ariana, Lairson, Luke L.

“…Pharmacology-based methods that promote antitumor immunity have the potential to be highly efficacious while avoiding the systemic cytotoxicity associated with…”
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Discovery of PLD4 modulators by high-throughput screening and kinetic analysis by Claire Lee, Jinny, Shirey, Ryan J., Turner, Lewis D., Park, Hyeri, Lairson, Luke L., Janda, Kim D.

“…[Display omitted] Phospholipase D3 (PLD3) and D4 (PLD4) are endolysosomal exonucleases of ssDNA and ssRNA that regulate innate immunity. Polymorphisms of these…”
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A new road to STING activation by Sulpizio, Ariana, Lairson, Luke L.

“…Activation of STING-dependent signal transduction results in adaptive immune responses that promote antitumor immunity. A recent study has identified a…”
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Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells by Staerk, Judith, Lyssiotis, Costas A., Medeiro, Lea A., Bollong, Michael, Foreman, Ruth K., Zhu, Shoutian, Garcia, Michael, Gao, Qing, Bouchez, Laure C., Lairson, Luke L., Charette, Bradley D., Supekova, Lubica, Janes, Jeffrey, Brinker, Achim, Cho, Charles Y., Jaenisch, Rudolf, Schultz, Peter G.

“…Small molecules do the job: Somatic cells are reprogrammed into iPS cells upon ectopic expression of Oct4, Sox2, Klf4 and c‐Myc. Application of a cell‐based,…”
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