Search Results - "Luke, R"

Reshaping endoplasmic reticulum quality control through the unfolded protein response by Wiseman, R. Luke, Mesgarzadeh, Jaleh S., Hendershot, Linda M.

“…Endoplasmic reticulum quality control (ERQC) pathways comprising chaperones, folding enzymes, and degradation factors ensure the fidelity of ER protein folding…”
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Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress by Rainbolt, T. Kelly, Lebeau, Justine, Puchades, Cristina, Wiseman, R. Luke

“…The mitochondrial inner membrane proteases YME1L and OMA1 are critical regulators of essential mitochondrial functions, including inner membrane proteostasis…”
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Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy by Plate, Lars, Wiseman, R. Luke

“…Imbalances in secretory proteostasis induced by genetic, environmental, or aging-related insults are pathologically associated with etiologically diverse…”
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An update on contextual fear memory mechanisms: Transition between Amygdala and Hippocampus by Chaaya, Nicholas, Battle, Andrew R., Johnson, Luke R.

“…•Contextual fear memories undergo consolidation in both amygdala and hippocampus.•The hippocampus maintains contextual fear memories.•The amygdala may also…”
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Visible‐Light Photocatalysis as an Enabling Tool for the Functionalization of Unactivated C(sp3)‐Substrates by Roslin, Sara, Odell, Luke R.

“…Over the past decade, visible‐light photocatalysis has emerged as one of the brightest and most dynamic fields in modern organic chemistry. By employing a…”
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The Blackberry Fruit: A Review on Its Composition and Chemistry, Metabolism and Bioavailability, and Health Benefits by Kaume, Lydia, Howard, Luke R, Devareddy, Latha

“…Blackberry (Rubus sp.) fruit contains high levels of anthocyanins and other phenolic compounds, mainly flavonols and ellagitannins, which contribute to its…”
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Safety of combining radiotherapy with immune-checkpoint inhibition by Hwang, William L., Pike, Luke R. G., Royce, Trevor J., Mahal, Brandon A., Loeffler, Jay S.

“…Immune-checkpoint inhibitors targeting cytotoxic T- lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), or programmed cell death 1 ligand 1…”
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Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis by Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.

“…Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with…”
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Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma by Bonser, Luke R, Zlock, Lorna, Finkbeiner, Walter, Erle, David J

“…The development of pathologic mucus, which is not readily cleared from the airways, is an important contributor to the morbidity and mortality associated with…”
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Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review by Stohs, Sidney J, Chen, Oliver, Ray, Sidhartha D, Ji, Jin, Bucci, Luke R, Preuss, Harry G

“…Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory,…”
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Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing by Puchades, Cristina, Rampello, Anthony J., Shin, Mia, Giuliano, Christopher J., Wiseman, R. Luke, Glynn, Steven E., Lander, Gabriel C.

“…We present an atomic model of a substrate-bound inner mitochondrial membrane AAA+ quality control protease in yeast, YME1. Our ~3.4-angstrom cryo-electron…”
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Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation by Rainbolt, T. Kelly, Atanassova, Neli, Genereux, Joseph C., Wiseman, R. Luke

“…Stress-regulated signaling pathways protect mitochondrial proteostasis and function from pathologic insults. Despite the importance of stress-regulated…”
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Plant organellar genomes: much done, much more to do by Wang, Jie, Kan, Shenglong, Liao, Xuezhu, Zhou, Jiawei, Tembrock, Luke R., Daniell, Henry, Jin, Shuangxia, Wu, Zhiqiang

“…Advances in technology have led to a large increase in the number of plant organellar sequences, but sampling remains uneven.Most land-plant mitogenomes are…”
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Decoding dissolved information: environmental DNA sequencing at global scale to monitor a changing ocean by Thompson, Luke R, Thielen, Peter

“…The use of environmental DNA (eDNA) technology for environmental monitoring is rapidly expanding, with applications for fisheries, coral reefs, harmful algal…”
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Internal mRNA 2'-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer by Frietze, Luke R, Pan, Tao

“…In this issue, Li et al. report internal mRNA 2'-O-methyl (Nm) modification mapping by nanopore sequencing and the effect of Nm on mRNA stability and cancer…”
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Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements by Yang, Jie, Song, Albert S., Wiseman, R. Luke, Lander, Gabriel C.

“…Lon protease is a conserved ATP-dependent serine protease composed of an AAA+ domain that mechanically unfolds substrates and a serine protease domain that…”
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Small molecule strategies to harness the unfolded protein response: where do we go from here? by Grandjean, Julia M.D., Wiseman, R.Luke

“…The unfolded protein response (UPR) plays a central role in regulating endoplasmic reticulum (ER) and global cellular physiology in response to pathologic ER…”
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Recent Research on the Health Benefits of Blueberries and Their Anthocyanins by Kalt, Wilhelmina, Cassidy, Aedin, Howard, Luke R, Krikorian, Robert, Stull, April J, Tremblay, Francois, Zamora-Ros, Raul

“…Awareness of the human health benefits of blueberries is underpinned by a growing body of positive scientific evidence from human observational and clinical…”
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Improved polygenic prediction by Bayesian multiple regression on summary statistics by Lloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian, Visscher, Peter M.

“…Accurate prediction of an individual’s phenotype from their DNA sequence is one of the great promises of genomics and precision medicine. We extend a powerful…”
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Emotional Intelligence Predicts Academic Performance: A Meta-Analysis by MacCann, Carolyn, Jiang, Yixin, Brown, Luke E. R., Double, Kit S., Bucich, Micaela, Minbashian, Amirali

“…Schools and universities devote considerable time and resources to developing students' social and emotional skills, such as emotional intelligence (EI). The…”
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