Search Results - "Luke, George M."

Synthesis of the anxiolytic agent [14C] 6-hydroxy-buspirone for use in a human ADME study by Bonacorsi Jr, Samuel J., Burrell, Richard C., Luke, George M., DePue, Jeffrey S., Kent Rinehart, J., Balasubramanian, Balu, Christopher, Lisa J., Iyer, Ramaswamy A.

“…A reliable synthesis of 14C labeled 6‐hydroxy‐buspirone is described. The molecule belongs to a unique class of compounds with the potential for anxiolytic…”
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Synthesis of 13C6-labeled Reyataz™ (BMS-232632) by Burrell, Richard C., Lago, Michael W., Luke, George M., Rinehart, J. Kent

“…An efficient synthesis of 13C6‐labeled Reyataz™ (BMS‐232632) is described. 13C6‐labeled Reyataz™ was synthesized in eight steps from commercially available…”
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Substituted benzamides. 1. Potential nondopaminergic antagonists of chemotherapy-induced nausea and emesis by Monkovic, Ivo, Willner, David, Adam, Michael A, Brown, Myron, Crenshaw, R. R, Fuller, Carl E, Juby, Peter F, Luke, George M, Matiskella, John A, Montzka, Thomas A

“…A series of new substituted benzamides has been synthesized and evaluated for dopamine antagonist activity and for antagonism of cisplatin-induced emesis in…”
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1,2,5-Thiadizole 1-oxide and 1,1-dioxide derivatives. A new class of potent histamine H2-receptor antagonists by Algieri, Aldo A, Luke, George M, Standridge, Robert T, Brown, Myron, Partyka, Richard A, Crenshaw, R. R

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Interferon inducing activities of derivatives of 1,3-dimethyl-4-(3-dimethylaminopropylamino)-1H-pyrazolo[3,4-b]quinoline and related compounds by Crenshaw, R. R, Luke, George M, Siminoff, Paul

“…Syntheses and interferon inducing acitivites are reported for 137 relatives of 1,3-dimethyl-4-(3-dimethylamino-propylamino)-1H-pyrazolo[3,4-b]quinoline (1)…”
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Potential antifertility agents. 6. Synthesis and biological activities of optical isomers of 4.beta.-(p-methoxyphenyl)-2.beta.-methylcyclohexane-.alpha.-carboxylic acid and related compounds by Crenshaw, R. R, Jenks, Thomas A, Luke, George M, Bialy, Gabriel

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Synthesis of13C6-labeled Reyataz? (BMS-232632) by Burrell, Richard C., Lago, Michael W., Luke, George M., Rinehart, J. Kent

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Potential antifertility agents. 7. Synthesis and biological activities of 2-, 3-, and 6-alkyl-substituted 4-aryl-2-methylcyclohexanecarboxylic acids by Crenshaw, R. R, Luke, George M, Jenks, Thomas A, Bialy, Gabriel

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Synthetic fibrinolytic agents. 2. Selected N-monosubstituted bis(tetrahydroisoquinolines) designed to possess enhanced bioavailability by Buchanan, Ronald L, Sprancmanis, Vilmars, Jenks, Thomas A, Crenshaw, R. R, Luke, George M

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Potential antifertility agents. 4. Biological properties of diastereoisomeric 4-aryl-2-methylcyclohexanecarboxylic acids and related compounds by Crenshaw, R. R, Luke, George M, Jenks, Thomas A, Partyka, Richard A, Bialy, Gabriel, Bierwagen, Max E

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Synthetic fibrinolytic agents. 1. N-Monoacyl, N-monoalkyl, and related bis(tetrahydroisoquinolines) by Buchanan, Ronald L, Sprancmanis, Vilmars, Jenks, Thomas A, Crenshaw, R. R, Luke, George M, Holava, Henry M, Partyka, Richard A

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Synthesis of 3 H and 14 C labeled (S)‐3‐(5‐chloro‐2‐methoxyphenyl)‐1,3‐dihydro‐3‐fluoro‐6‐(trifluoromethyl)‐2H‐indol‐2‐one, maxipost™. An agent for post‐stroke neuroprotection by Dischino, Douglas D., Gribkoff, Valentin K., Hewawasam, Piyasena, Luke, George M., Rinehart, J. Kent, Spears, Tony L., Starrett, John E.

“…Abstract The syntheses of tritium labeled ( S )‐3‐(5‐chloro‐2‐[OC 3 H 3 ]methoxyphenyl‐1,3‐dihydro‐3‐fluoro‐6‐(trifluoromethyl)‐1H‐indol‐2‐one, and carbon‐14 (…”
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Synthesis of 3H and 14C labeled (S)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indol-2-one, maxipost™. An agent for post-stroke neuroprotection by Dischino, Douglas D., Gribkoff, Valentin K., Hewawasam, Piyasena, Luke, George M., Rinehart, J. Kent, Spears, Tony L., Starrett Jr, John E.

“…The syntheses of tritium labeled (S)‐3‐(5‐chloro‐2‐[OC3H3]methoxyphenyl‐1,3‐dihydro‐3‐fluoro‐6‐(trifluoromethyl)‐1H‐indol‐2‐one, and carbon‐14…”
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Synthesis of 3H and 14C labeled (S)-3-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-ind ol-2-one, MaxiPost. An agent for post-stroke neuroprotection by DISCHINO, Douglas D, GRIBKOFF, Valentin K, HEWAWASAM, Piyasena, LUKE, George M, RINEHART, J. Kent, SPEARS, Tony L, JR, John E

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1,2,5-thiadiazole 1-oxide and 1,1-dioxide derivatives. A new class of potent histamine H2-receptor antagonists by Algieri, A A, Luke, G M, Standridge, R T, Brown, M, Partyka, R A, Crenshaw, R R

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