Search Results - "Lukaszewski, Roman"

Developing and understanding biofluid vibrational spectroscopy: a critical review by Baker, Matthew J, Hussain, Shawn R, Lovergne, Lila, Untereiner, Valérie, Hughes, Caryn, Lukaszewski, Roman A, Thiéfin, Gérard, Sockalingum, Ganesh D

“…Vibrational spectroscopy can provide rapid, label-free, and objective analysis for the clinical domain. Spectroscopic analysis of biofluids such as blood…”
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Targeting the “Cytokine Storm” for Therapeutic Benefit by D'Elia, Riccardo V, Harrison, Kate, Oyston, Petra C, Lukaszewski, Roman A, Clark, Graeme C

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Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures by Lukaszewski, Roman A., Jones, Helen E., Gersuk, Vivian H., Russell, Paul, Simpson, Andrew, Brealey, David, Walker, Jonathan, Thomas, Matt, Whitehouse, Tony, Ostermann, Marlies, Koch, Alexander, Zacharowski, Kai, Kruhoffer, Mogens, Chaussabel, Damien, Singer, Mervyn

“…Purpose Early accurate diagnosis of infection ± organ dysfunction (sepsis) remains a major challenge in clinical practice. Utilizing effective biomarkers to…”
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The use of colorimetric sensor arrays to discriminate between pathogenic bacteria by Lonsdale, Claire L, Taba, Brian, Queralto, Nuria, Lukaszewski, Roman A, Martino, Raymond A, Rhodes, Paul A, Lim, Sung H

“…A colorimetric sensor array is a high-dimensional chemical sensor that is cheap, compact, disposable, robust, and easy to operate, making it a good candidate…”
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Observations on the Inactivation Efficacy of a MALDI-TOF MS Chemical Extraction Method on Bacillus anthracis Vegetative Cells and Spores by Weller, Simon A, Stokes, Margaret G M, Lukaszewski, Roman A

“…A chemical (ethanol; formic acid; acetonitrile) protein extraction method for the preparation of bacterial samples for matrix assisted laser desorption…”
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The potential of TaqMan Array Cards for detection of multiple biological agents by real-time PCR by Rachwal, Phillip A, Rose, Helen L, Cox, Victoria, Lukaszewski, Roman A, Murch, Amber L, Weller, Simon A

“…The TaqMan Array Card architecture, normally used for gene expression studies, was evaluated for its potential to detect multiple bacterial agents by real-time…”
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Stochastic dynamics of Francisella tularensis infection and replication by Carruthers, Jonathan, Lythe, Grant, López-García, Martín, Gillard, Joseph, Laws, Thomas R, Lukaszewski, Roman, Molina-París, Carmen, Papin, Jason A, O'Dwyer, James

“…We study the pathogenesis of Francisella tularensis infection with an experimental mouse model, agent-based computation and mathematical analysis. Following…”
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Risk assessment with gene expression markers in sepsis development by Garcia Lopez, Albert, Schäuble, Sascha, Sae-Ong, Tongta, Seelbinder, Bastian, Bauer, Michael, Giamarellos-Bourboulis, Evangelos J., Singer, Mervyn, Lukaszewski, Roman, Panagiotou, Gianni

“…Infection is a commonplace, usually self-limiting, condition but can lead to sepsis, a severe life-threatening dysregulated host response. We investigate the…”
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Pathogenesis of Yersinia pestis Infection in BALB/c Mice: Effects on Host Macrophages and Neutrophils by LUKASZEWSKI, Roman A, KENNY, Dermot J, TAYLOR, Rosa, REES, D. G, HARTLEY, M. Gill, OYSTON, Petra C. F

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Evaluation of two multiplex real-time PCR screening capabilities for the detection of Bacillus anthracis, Francisella tularensis and Yersinia pestis in blood samples generated from murine infection models by WELLER, Simon A, COX, Victoria, ESSEX-LOPRESTI, Angela, HARTLEY, Margaret G, PARSONS, Tanya M, RACHWAL, Phillip A, STAPLETON, Helen L, LUKASZEWSKI, Roman A

“…Two multiplex PCR screening capabilities (TaqMan Array Cards and FilmArray) were evaluated for their ability to detect Bacillus anthracis, Francisella…”
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Multiple metabolic pathways are predictive of ricin intoxication in a rat model by D’Elia, Riccardo V., Goodchild, Sarah A., Winder, Catherine L., Southam, Andrew D., Weber, Ralf J. M., Stahl, Fiona M., Docx, Cerys, Patel, Vikesh, Green, A. Christopher, Viant, Mark R., Lukaszewski, Roman A., Dunn, Warwick B.

“…Introduction Exposure to ricin can be lethal and treatments that are under development have short windows of opportunity for administration after exposure. It…”
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Targeting the “Rising DAMP” during a Francisella tularensis Infection by D'ELIA, Riccardo V, LAWS, Thomas R, CARTER, Alun, LUKASZEWSKI, Roman, CLARK, Graeme C

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Combining Vaccination and Postexposure CpG Therapy Provides Optimal Protection Against Lethal Sepsis in a Biodefense Model of Human Melioidosis by Easton, Anna, Haque, Ashraful, Chu, Karen, Patel, Natasha, Lukaszewski, Roman A., Krieg, Arthur M., Titball, Richard W., Bancroft, Gregory J.

“…The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a major cause of lethal sepsis and morbidity in endemic areas of…”
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Gene expression following low dose inhalational Francisella tularensis (SchuS4) exposure in Balb/c mice and the potential role of the epithelium and cell adhesion by David, Jonathan, Gates, Amanda J., Griffiths, Gareth D., Lukaszewski, Roman A.

“…Interactions between Francisella tularensis and the host are slowly being elucidated. Microarray technology was used to further characterise the response of…”
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Neutrophils are the predominant cell-type to associate with Burkholderia pseudomallei in a BALB/c mouse model of respiratory melioidosis by Laws, Thomas R., Smither, Sophie J., Lukaszewski, Roman A., Atkins, Helen S.

“…A variety of studies have implicated neutrophils and the rapid induction of cytokine in the host response in melioidosis. Here a BALB/c mouse model of…”
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Common Host Responses in Murine Aerosol Models of Infection Caused by Highly Virulent Gram-Negative Bacteria from the Genera Burkholderia, Francisella and Yersinia by Clark, Graeme C, Essex-Lopresti, Angela, Moore, Karen A, Williamson, E Diane, Lukaszewski, Roman, Paszkiewicz, Konrad, David, Jonathan

“…Highly virulent bacterial pathogens cause acute infections which are exceptionally difficult to treat with conventional antibiotic therapies alone…”
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Administration of Antibody to the Lung Protects Mice against Pneumonic Plague by Hill, Jim, Eyles, Jim E, Elvin, Stephen J, Healey, Gareth D, Lukaszewski, Roman A, Titball, Richard W

“…Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic…”
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Host immunity in the protective response to vaccination with heat-killed Burkholderia mallei by Whitlock, Gregory C, Lukaszewski, Roman A, Judy, Barbara M, Paessler, Slobodan, Torres, Alfredo G, Estes, D Mark

“…We performed initial cell, cytokine and complement depletion studies to investigate the possible role of these effectors in response to vaccination with…”
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CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner by Rees, D.G. Cerys, Phillpotts, Robert J, Griffin, Kate F, Lukaszewski, Roman A, Laws, Thomas R, Atkins, Helen S, Krieg, Arthur M, Titball, Richard W

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Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide by Williamson, Diane, Rowland, Caroline A., Hartley, M. Gillian, Gates, Amanda J., Newstead, Sarah L., Lukaszewski, Roman A.

“…Reactive nitrogen is critical for the clearance of Francisella tularensis infections. Here we assess the role of nitric oxide in control of intracellular…”
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