Search Results - "Lukashevich, Igor"

ICTV Virus Taxonomy Profile: Arenaviridae by Radoshitzky, Sheli R, Buchmeier, Michael J, Charrel, Rémi N, Clegg, J Christopher S, Gonzalez, Jean-Paul J, Günther, Stephan, Hepojoki, Jussi, Kuhn, Jens H, Lukashevich, Igor S, Romanowski, Víctor, Salvato, Maria S, Sironi, Manuela, Stenglein, Mark D, de la Torre, Juan Carlos, ICTV Report Consortium

“…Members of the family Arenaviridae produce enveloped virions containing genomes consisting of two or three single-stranded RNA segments totalling about 10.5…”
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Live-attenuated CHIKV vaccine with rearranged genome replicates in vitro and induces immune response in mice by Tretyakova, Irina, Joh, Joongho, Gearon, Mary, Kraenzle, Jennifer, Goedeker, Sidney, Pignataro, Ava, Alejandro, Brian, Lukashevich, Igor S, Chung, Donghoon, Pushko, Peter

“…Chikungunya fever virus (CHIKV) is a mosquito-borne alphavirus that causes wide-spread human infections and epidemics in Asia, Africa and recently, in the…”
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Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins by Wang, Min, Jokinen, Jenny, Tretyakova, Irina, Pushko, Peter, Lukashevich, Igor S.

“…•High genetic diversity of LASV is one of the great challenges for vaccine R&D.•VEEV TC-83 vaccine was used to design bivalent virus-like-particle-vectors,…”
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Vaccine platforms to control Lassa fever by Lukashevich, Igor S, Pushko, Peter

“…Lassa virus (LASV), the most prominent human pathogen of the Arenaviridae, is transmitted to humans from infected rodents and can cause Lassa Fever (LF). The…”
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ICTV Virus Taxonomy Profile: Arenaviridae 2023 by Radoshitzky, Sheli R, Buchmeier, Michael J, Charrel, Rémi N, Gonzalez, Jean-Paul J, Günther, Stephan, Hepojoki, Jussi, Kuhn, Jens H, Lukashevich, Igor S, Romanowski, Víctor, Salvato, Maria S, Sironi, Manuela, Stenglein, Mark D, Torre, Juan Carlos de la

“…is a family for ambisense RNA viruses with genomes of about 10.5 kb that infect mammals, snakes, and fish. The arenavirid genome consists of two or three…”
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Single-Dose Immunogenic DNA Vaccines Coding for Live-Attenuated Alpha- and Flaviviruses by Pushko, Peter, Lukashevich, Igor S, Johnson, Dylan M, Tretyakova, Irina

“…Single-dose, immunogenic DNA (iDNA) vaccines coding for whole live-attenuated viruses are reviewed. This platform, sometimes called immunization DNA, has been…”
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The search for animal models for Lassa fever vaccine development by Lukashevich, Igor S

“…Lassa virus (LASV) is the most prevalent arenavirus in West Africa and is responsible for several hundred thousand infections and thousands of deaths annually…”
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Novel DNA-launched Venezuelan equine encephalitis virus vaccine with rearranged genome by Tretyakova, Irina, Tibbens, Alexander, Jokinen, Jenny D., Johnson, Dylan M., Lukashevich, Igor S., Pushko, Peter

“…•Live-attenuated V4020 VEEV vaccine with rearranged structural genes is described.•V4020 included attenuating mutations engineered to prevent…”
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Plasmid DNA initiates replication of yellow fever vaccine in vitro and elicits virus-specific immune response in mice by Tretyakova, Irina, Nickols, Brian, Hidajat, Rachmat, Jokinen, Jenny, Lukashevich, Igor S, Pushko, Peter

“…Abstract Yellow fever (YF) causes an acute hemorrhagic fever disease in tropical Africa and Latin America. To develop a novel experimental YF vaccine, we…”
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Lassa Virus Vaccine Candidate ML29 Generates Truncated Viral RNAs Which Contribute to Interfering Activity and Attenuation by Johnson, Dylan M, Cubitt, Beatrice, Pfeffer, Tia L, de la Torre, Juan Carlos, Lukashevich, Igor S

“…Defective interfering particles (DIPs) are naturally occurring products during virus replication in infected cells. DIPs contain defective viral genomes (DVGs)…”
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Past, present, and future of arenavirus taxonomy by Radoshitzky, Sheli R, Bào, Yīmíng, Buchmeier, Michael J, Charrel, Rémi N, Clawson, Anna N, Clegg, Christopher S, DeRisi, Joseph L, Emonet, Sébastien, Gonzalez, Jean-Paul, Kuhn, Jens H, Lukashevich, Igor S, Peters, Clarence J, Romanowski, Victor, Salvato, Maria S, Stenglein, Mark D, de la Torre, Juan Carlos

“…Until recently, members of the monogeneric family Arenaviridae (arenaviruses) have been known to infect only muroid rodents and, in one case, possibly…”
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Bivalent Junin & Machupo experimental vaccine based on alphavirus RNA replicon vector by Johnson, Dylan M., Jokinen, Jenny D., Wang, Min, Pfeffer, Tia, Tretyakova, Irina, Carrion, Ricardo, Griffiths, Anthony, Pushko, Peter, Lukashevich, Igor S.

“…Junin (JUNV) and Machupo (MACV), two mammalian arenaviruses placed on the 2018 WHO watch list, are prevalent in South America causing Argentine and Bolivian…”
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Pathogenic and Apathogenic Strains of Lymphocytic Choriomeningitis Virus Have Distinct Entry and Innate Immune Activation Pathways by Johnson, Dylan M, Khakhum, Nittaya, Wang, Min, Warner, Nikole L, Jokinen, Jenny D, Comer, Jason E, Lukashevich, Igor S

“…Lymphocytic choriomeningitis virus (LCMV) and Lassa virus (LASV) share many genetic and biological features including subtle differences between pathogenic and…”
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Special Issue "Arenaviruses 2020" by Lukashevich, Igor S, Torre, Juan Carlos de la

“…Rodent-borne arenaviruses have been traditionally predominantly associated with certain muroid species from genera (African arenaviruses) or with species that…”
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Venezuelan equine encephalitis vaccine with rearranged genome resists reversion and protects non-human primates from viremia after aerosol challenge by Tretyakova, Irina, Plante, Kenneth S., Rossi, Shannan L., Lawrence, William S., Peel, Jennifer E., Gudjohnsen, Sif, Wang, Eryu, Mirchandani, Divya, Tibbens, Alexander, Lamichhane, Tek N., Lukashevich, Igor S., Comer, Jason E., Weaver, Scott C., Pushko, Peter

“…•Live-attenuated V4020 VEEV vaccine virus contains rearranged structural genes.•V4020 includes attenuating mutations from TC83 vaccine engineered to prevent…”
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Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine by Tretyakova, Irina, Lukashevich, Igor S, Glass, Pamela, Wang, Eryu, Weaver, Scott, Pushko, Peter

“…Highlights ► Novel iDNA platform was used for vaccination against VEEV alphavirus. ► Less than 10 ng of pTC83 iDNA initiated replication of the vaccine virus…”
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Advanced vaccine candidates for Lassa fever by Lukashevich, Igor S

“…Lassa virus (LASV) is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and…”
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DNA-launched live-attenuated vaccines for biodefense applications by Pushko, Peter, Lukashevich, Igor S, Weaver, Scott C, Tretyakova, Irina

“…A novel vaccine platform uses DNA immunization to launch live-attenuated virus vaccines in vivo. This technology has been applied for vaccine development…”
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Lassa virus diversity and feasibility for universal prophylactic vaccine [version 1; peer review: 3 approved] by Lukashevich, Igor S, Paessler, Slobodan, de la Torre, Juan Carlos

“…Lassa virus (LASV) is a highly prevalent mammarenavirus in West Africa and is maintained in nature in a persistently infected rodent host, Mastomys natalensis,…”
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Diagnostics for Lassa Fever: Detecting Host Antibody Responses by Salvato, Maria S, Lukashevich, Igor S, Medina-Moreno, Sandra, Zapata, Juan Carlos

“…There are two types of viral diagnostics: (1) those that detect components of the pathogen (like viral RNA or proteins) and (2) those that detect host…”
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