Search Results - "Lukas, Arno"

Predictive Biomarkers for Linking Disease Pathology and Drug Effect by Mayer, Bernd, Heinzel, Andreas, Lukas, Arno, Perco, Paul

“…Productivity in drug R&D continues seeing significant attrition in clinical stage testing. Approval of new molecular entities proceeds with slow pace…”
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Synthetic lethality guiding selection of drug combinations in ovarian cancer by Heinzel, Andreas, Marhold, Maximilian, Mayer, Paul, Schwarz, Michael, Tomasich, Erwin, Lukas, Arno, Krainer, Michael, Perco, Paul

“…Synthetic lethality describes a relationship between two genes where single loss of either gene does not trigger significant impact on cell viability, but…”
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Biomarker panels for characterizing microbial community biofilm formation as composite molecular process by Bosse, Magnus, Heuwieser, Alexander, Heinzel, Andreas, Lukas, Arno, Oliveira, Guilherme, Mayer, Bernd

“…Microbial consortia execute collaborative molecular processes with contributions from individual species, on such basis enabling optimized molecular function…”
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Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress by Wilmes, Anja, Limonciel, Alice, Aschauer, Lydia, Moenks, Konrad, Bielow, Chris, Leonard, Martin O., Hamon, Jeremy, Carpi, Donatella, Ruzek, Silke, Handler, Andreas, Schmal, Olga, Herrgen, Karin, Bellwon, Patricia, Burek, Christof, Truisi, Germaine L., Hewitt, Philip, Di Consiglio, Emma, Testai, Emanuela, Blaauboer, Bas J., Guillou, Claude, Huber, Christian G., Lukas, Arno, Pfaller, Walter, Mueller, Stefan O., Bois, Frederic Y., Dekant, Wolfgang, Jennings, Paul

“…High content omic techniques in combination with stable human in vitro cell culture systems have the potential to improve on current pre-clinical safety…”
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Characterization of protein-interaction networks in tumors by Platzer, Alexander, Perco, Paul, Lukas, Arno, Mayer, Bernd

“…Analyzing differential-gene-expression data in the context of protein-interaction networks (PINs) yields information on the functional cellular status. PINs…”
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Mouse Mammary Tumor Virus Integration Site Selection in Human and Mouse Genomes by FASCHINGER, Alexander, ROUAULT, Francoise, SOLLNER, Johannes, LUKAS, Arno, SALMONS, Brian, GÜNZBURG, Walter H, INDIK, Stanislav

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Análise de artigos científicos publicados em dois periódicos da área de ortopedia geral by Holzer, Lukas Arno, Holzer, Gerold

“…OBJETIVO: Dar uma visão geral sobre o comportamento e a contribuição científica do Journal of Bone and Joint Surgery versão Americana (JBJS-A) e versão…”
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Body mass index is the main risk factor for arterial hypertension in young subjects without major comorbidity by Lukas, Arno, Kumbein, Friedrich, Temml, Christian, Mayer, Bernd, Oberbauer, Rainer

“…Background Analytical statistics revealed a variety of risk factors for hypertension, but the complex interplay between different factors remains to be…”
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Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study by Aschauer, Lydia, Limonciel, Alice, Wilmes, Anja, Stanzel, Sven, Kopp-Schneider, Annette, Hewitt, Philip, Lukas, Arno, Leonard, Martin O., Pfaller, Walter, Jennings, Paul

“…[Display omitted] •RPTEC/TERT1 cells are an excellent tool for repeat dose toxicity applications.•Transcriptomics is more sensitive and more informative than…”
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Quantitative in vitro to in vivo extrapolation of tissues toxicity by Hamon, Jérémy, Renner, Maria, Jamei, Masoud, Lukas, Arno, Kopp-Schneider, Annette, Bois, Frédéric Y.

“…•We develop several mechanistic dose–response models.•We insist on the development of systems biology models for predictive toxicology.•We couple a systems…”
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Validation of a protein panel for the noninvasive detection of recurrent non-muscle invasive bladder cancer by Gogalic, Selma, Sauer, Ursula, Doppler, Sara, Heinzel, Andreas, Perco, Paul, Lukas, Arno, Simpson, Guy, Pandha, Hardev, Horvath, Andras, Preininger, Claudia

“…Context: About 50-70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease. Objective: To establish a panel of protein…”
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Vascular endothelial growth factor A as predictive marker for mTOR inhibition in relapsing high-grade serous ovarian cancer by Andorfer, Peter, Heuwieser, Alexander, Heinzel, Andreas, Lukas, Arno, Mayer, Bernd, Perco, Paul

“…Development of resistance against first line drug therapy including cisplatin and paclitaxel in high-grade serous ovarian cancer (HGSOC) presents a major…”
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Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing by Crean, Daniel, Bellwon, Patricia, Aschauer, Lydia, Limonciel, Alice, Moenks, Konrad, Hewitt, Philip, Schmidt, Tobias, Herrgen, Karin, Dekant, Wolfgang, Lukas, Arno, Bois, Frederic, Wilmes, Anja, Jennings, Paul, Leonard, Martin O.

“…•Adefovir toxicity in proximal tubular cells is enhanced under hypoxic stress.•Adefovir accumulation in hypoxia is paralleled by reduction in efflux regulators…”
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Linking transcriptomic and proteomic data on the level of protein interaction networks by Perco, Paul, Mühlberger, Irmgard, Mayer, Gert, Oberbauer, Rainer, Lukas, Arno, Mayer, Bernd

“…Integration and joint analysis of omics profiles derived on the genome, transcriptome, proteome and metabolome levels is a natural next step in realizing a…”
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Interleukin-19 as a translational indicator of renal injury by Jennings, Paul, Crean, Daniel, Aschauer, Lydia, Limonciel, Alice, Moenks, Konrad, Kern, Georg, Hewitt, Philip, Lhotta, Karl, Lukas, Arno, Wilmes, Anja, Leonard, Martin O.

“…Accurate detection and prediction of renal injury are central not only to improving renal disease management but also for the development of new strategies to…”
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Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures by Parmentier, Céline, Truisi, Germaine L, Moenks, Konrad, Stanzel, Sven, Lukas, Arno, Kopp-Schneider, Annette, Alexandre, Eliane, Hewitt, Philip G, Mueller, Stefan O, Richert, Lysiane

“…Drug-induced liver injury is the most frequent reason for market withdrawal of approved drugs, and is difficult to predict in animal models. Here, we analyzed…”
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Molecular models of the cardiorenal syndrome by Heinzel, Andreas, Fechete, Raul, Mühlberger, Irmgard, Perco, Paul, Mayer, Bernd, Lukas, Arno

“…Molecular profiling techniques have provided extensive sets of molecular features characterizing clinical phenotypes, but further extrapolation to mechanistic…”
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Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing by Limonciel, Alice, Moenks, Konrad, Stanzel, Sven, Truisi, Germaine L., Parmentier, Céline, Aschauer, Lydia, Wilmes, Anja, Richert, Lysiane, Hewitt, Philip, Mueller, Stefan O., Lukas, Arno, Kopp-Schneider, Annette, Leonard, Martin O., Jennings, Paul

“…•Transcriptomics are ideal to study the modulation of transcription factor (TF) activity.•Stress response and ligand-activated pathways regulate cell functions…”
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Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic by De Paoli, Marine, Perco, Paul, Mühlberger, Irmgard, Lukas, Arno, Pandha, Hardev, Morgan, Richard, Feng, Gui Jie, Marquette, Christophe

“…Context: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer. Objective: To…”
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Identification of discontinuous antigenic determinants on proteins based on shape complementarities by Rapberger, Ronald, Lukas, Arno, Mayer, Bernd

“…Diverse procedures for identifying antigenic determinants on proteins have been developed, including experimental as well as computational approaches. However,…”
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