Search Results - "Lukacs, L"

Food Allergy Among Children in the United States by Branum, Amy M, Lukacs, Susan L

“…The goals were to estimate the prevalence of food allergy and to describe trends in food allergy prevalence and health care use among US children. A…”
Get full text

Mechanism of parkin activation by phosphorylation by Sauvé, Véronique, Sung, George, Soya, Naoto, Kozlov, Guennadi, Blaimschein, Nina, Miotto, Lis Schwartz, Trempe, Jean-François, Lukacs, Gergely L., Gehring, Kalle

“…Mutations in the ubiquitin ligase parkin are responsible for a familial form of Parkinson’s disease. Parkin and the PINK1 kinase regulate a quality-control…”
Get full text

PINK1 autophosphorylation is required for ubiquitin recognition by Rasool, Shafqat, Soya, Naoto, Truong, Luc, Croteau, Nathalie, Lukacs, Gergely L, Trempe, Jean‐François

“…Mutations in PINK1 cause autosomal recessive Parkinson's disease (PD), a neurodegenerative movement disorder. PINK1 is a kinase that acts as a sensor of…”
Get full text

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations by Veit, Gudio, Avramescu, Radu G, Chiang, Annette N, Houck, Scott A, Cai, Zhiwei, Peters, Kathryn W, Hong, Jeong S, Pollard, Harvey B, Guggino, William B, Balch, William E, Skach, William R, Cutting, Garry R, Frizzell, Raymond A, Sheppard, David N, Cyr, Douglas M, Sorscher, Eric J, Brodsky, Jeffrey L, Lukacs, Gergely L

“…More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) have been described that confer a range of molecular cell biological…”
Get full text

SARS-CoV-2 Seroprevalence among Healthcare, First Response, and Public Safety Personnel, Detroit Metropolitan Area, Michigan, USA, May-June 2020 by Akinbami, Lara J, Vuong, Nga, Petersen, Lyle R, Sami, Samira, Patel, Anita, Lukacs, Susan L, Mackey, Lisa, Grohskopf, Lisa A, Shehu, Amy, Atas, Jenny

“…To estimate seroprevalence of severe acute respiratory syndrome 2 (SARS-CoV-2) among healthcare, first response, and public safety personnel, antibody testing…”
Get full text

Ubiquitin-dependent sorting in endocytosis by Piper, Robert C, Dikic, Ivan, Lukacs, Gergely L

“…When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs them through a series of sorting steps that culminate in their delivery…”
Get full text

Cooperative assembly and misfolding of CFTR domains in vivo by Du, Kai, Lukacs, Gergely L

“…The cystic fibrosis transmembrane conductance regulator (CFTR) architecture consists of two membrane spanning domains (MSD1 and -2), two nucleotide binding…”
Get full text

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination by Veit, Guido, Roldan, Ariel, Hancock, Mark A, Da Fonte, Dillon F, Xu, Haijin, Hussein, Maytham, Frenkiel, Saul, Matouk, Elias, Velkov, Tony, Lukacs, Gergely L

“…Based on its clinical benefits, Trikafta - the combination of folding correctors VX-661 (tezacaftor), VX-445 (elexacaftor), and the gating potentiator VX-770…”
Get full text

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane by Okiyoneda, Tsukasa, Barrière, Hervé, Bagdány, Miklós, Rabeh, Wael M, Du, Kai, Höhfeld, Jörg, Young, Jason C, Lukacs, Gergely L

“…Therapeutic efforts to restore biosynthetic processing of the cystic fibrosis transmembrane conductance regulator lacking the F508 residue (ΔF508CFTR) are…”
Get full text

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function by Rabeh, Wael M., Bossard, Florian, Xu, Haijin, Okiyoneda, Tsukasa, Bagdany, Miklos, Mulvihill, Cory M., Du, Kai, di Bernardo, Salvatore, Liu, Yuhong, Konermann, Lars, Roldan, Ariel, Lukacs, Gergely L.

“…The folding and misfolding mechanism of multidomain proteins remains poorly understood. Although thermodynamic instability of the first nucleotide-binding…”
Get full text

Prevalence of SARS-CoV-2 Antibodies in First Responders and Public Safety Personnel, New York City, New York, USA, May-July 2020 by Sami, Samira, Akinbami, Lara J, Petersen, Lyle R, Crawley, Addie, Lukacs, Susan L, Weiss, Don, Henseler, Rebecca A, Vuong, Nga, Mackey, Lisa, Patel, Anita, Grohskopf, Lisa A, Morgenthau, Beth Maldin, Daskalakis, Demetre, Pathela, Preeti

“…We conducted a serologic survey in public service agencies in New York City, New York, USA, during May-July 2020 to determine prevalence of severe acute…”
Get full text

Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis by Maléth, József, Balázs, Anita, Pallagi, Petra, Balla, Zsolt, Kui, Balázs, Katona, Máté, Judák, Linda, Németh, István, Kemény, Lajos V., Rakonczay, Zoltán, Venglovecz, Viktória, Földesi, Imre, Pető, Zoltán, Somorácz, Áron, Borka, Katalin, Perdomo, Doranda, Lukacs, Gergely L., Gray, Mike A., Monterisi, Stefania, Zaccolo, Manuela, Sendler, Matthias, Mayerle, Julia, Kühn, Jens-Peter, Lerch, Markus M., Sahin-Tóth, Miklós, Hegyi, Péter

“…Excessive consumption of ethanol is one of the most common causes of acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis…”
Get full text

Selective Binding of HSC70 and its Co-Chaperones to Structural Hotspots on CFTR by Baaklini, Imad, Gonçalves, Conrado de Campos, Lukacs, Gergely L., Young, Jason C.

“…Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel cause cystic fibrosis. Chaperones, including HSC70, DNAJA1 and DNAJA2, play…”
Get full text

Fixing cystic fibrosis by correcting CFTR domain assembly by Okiyoneda, Tsukasa, Lukacs, Gergely L

“…For cystic fibrosis (CF) patients most therapies focus on alleviating the disease symptoms. Yet the cellular basis of the disease has been well studied;…”
Get full text

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain–domain coupling by Soya, Naoto, Xu, Haijin, Roldan, Ariel, Yang, Zhengrong, Ye, Haoxin, Jiang, Fan, Premchandar, Aiswarya, Veit, Guido, Cole, Susan P. C., Kappes, John, Hegedüs, Tamás, Lukacs, Gergely L.

“…The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC) C-subfamily transporters, essential for organismal health, remain…”
Get full text

Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects by Egan, Marie E., Pearson, Marilyn, Weiner, Scott A., Rajendran, Vanathy, Rubin, Daniel, Glöckner-Pagel, Judith, Canny, Susan, Du, Kai, Lukacs, Gergely L., Caplan, Michael J.

“…Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation, ΔF508,…”
Get full text

Mutation-specific downregulation of CFTR2 variants by gating potentiators by Avramescu, Radu G, Kai, Yukari, Xu, Haijin, Bidaud-Meynard, Aurélien, Schnúr, Andrea, Frenkiel, Saul, Matouk, Elias, Veit, Guido, Lukacs, Gergely L

“…Approximately 50% of cystic fibrosis (CF) patients are heterozygous with a rare mutation on at least one allele. Several mutants exhibit functional defects,…”
Get full text

Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy by Phuan, Puay-Wah, Veit, Guido, Tan, Joseph, Roldan, Ariel, Finkbeiner, Walter E, Lukacs, Gergely L, Verkman, A S

“…The most prevalent cystic fibrosis transmembrane conductance regulator (CFTR) mutation causing cystic fibrosis, ΔF508, impairs folding of nucleotide binding…”
Get more information

Protein homeostasis at the plasma membrane by Apaja, Pirjo M, Lukacs, Gergely L

“…The plasma membrane (PM) and endocytic protein quality control (QC) in conjunction with the endosomal sorting machinery either repairs or targets…”
Get full text

Intracellular routing of plasmid DNA during non-viral gene transfer by Lechardeur, Delphine, Verkman, A.S., Lukacs, Gergely L.

“…Gene transfer using non-viral vectors is a promising approach for the safe delivery of therapeutic DNA in genetic and acquired human diseases. Whereas the lack…”
Get full text