Search Results - "Lukáš, E."

Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis by Brümmer, Lukas E, Katzenschlager, Stephan, Gaeddert, Mary, Erdmann, Christian, Schmitz, Stephani, Bota, Marc, Grilli, Maurizio, Larmann, Jan, Weigand, Markus A, Pollock, Nira R, Macé, Aurélien, Carmona, Sergio, Ongarello, Stefano, Sacks, Jilian A, Denkinger, Claudia M

“…SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs) are increasingly being integrated in testing strategies around the world. Studies of the Ag-RDTs have shown…”
Get full text

Modeling Disease In Vivo With CRISPR/Cas9 by Dow, Lukas E

“…The recent advent of CRISPR/Cas9-mediated genome editing has created a wave of excitement across the scientific research community, carrying the promise of…”
Get full text

Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils by Heeb, Lukas E. M., Egholm, Cecilie, Boyman, Onur

“…The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins. Activation…”
Get full text

WNT as a Driver and Dependency in Cancer by Parsons, Marie J, Tammela, Tuomas, Dow, Lukas E

“…The WNT signaling pathway is a critical regulator of development and adult tissue homeostasis and becomes dysregulated in many cancer types. Although…”
Get more information

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer by Dow, Lukas E., O’Rourke, Kevin P., Simon, Janelle, Tschaharganeh, Darjus F., van Es, Johan H., Clevers, Hans, Lowe, Scott W.

“…The adenomatous polyposis coli (APC) tumor suppressor is mutated in the vast majority of human colorectal cancers (CRC) and leads to deregulated Wnt signaling…”
Get full text

Two-year follow-up of two patients after severe thallium intoxication by Pelclová, D, Urban, P, Ridzon, P, Senholdová, Z, Lukás, E, Diblík, P, Lacina, L

“…Information on the prognosis and electrophysiological follow-up of severe thallium poisoning is limited. We report two patients (mother and daughter) who were…”
Get more information

CRISPR in cancer biology and therapy by Katti, Alyna, Diaz, Bianca J., Caragine, Christina M., Sanjana, Neville E., Dow, Lukas E.

“…Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming biomedical research and providing entirely new approaches for…”
Get full text

Adding New Dimensions to 3D Cancer Models by Chu, Kevan, Dow, Lukas E

“…Understanding patient-specific responses to anticancer therapies and how individual tumors interact with their tumor microenvironment (TME) is a challenging…”
Get full text

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference by Premsrirut, Prem K., Dow, Lukas E., Kim, Sang Yong, Camiolo, Matthew, Malone, Colin D., Miething, Cornelius, Scuoppo, Claudio, Zuber, Johannes, Dickins, Ross A., Kogan, Scott C., Shroyer, Kenneth R., Sordella, Raffaella, Hannon, Gregory J., Lowe, Scott W.

“…RNA interference is a powerful tool for studying gene function, however, the reproducible generation of RNAi transgenic mice remains a significant limitation…”
Get full text

Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8-TCDD: follow-up 35 years after exposure by Urban, P., Pelclová, D., Lukáš, E., Kupka, K., Preiss, J., Fenclová, Z., Šmerhovský, Z.

“…Between 1965 and 1968, about 350 workers were accidentally exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in a chemical plant, which was producing…”
Get full text

SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care by Gutmann, Clemens, Takov, Kaloyan, Burnap, Sean A., Singh, Bhawana, Ali, Hashim, Theofilatos, Konstantinos, Reed, Ella, Hasman, Maria, Nabeebaccus, Adam, Fish, Matthew, McPhail, Mark JW, O’Gallagher, Kevin, Schmidt, Lukas E., Cassel, Christian, Rienks, Marieke, Yin, Xiaoke, Auzinger, Georg, Napoli, Salvatore, Mujib, Salma F., Trovato, Francesca, Sanderson, Barnaby, Merrick, Blair, Niazi, Umar, Saqi, Mansoor, Dimitrakopoulou, Konstantina, Fernández-Leiro, Rafael, Braun, Silke, Kronstein-Wiedemann, Romy, Doores, Katie J., Edgeworth, Jonathan D., Shah, Ajay M., Bornstein, Stefan R., Tonn, Torsten, Hayday, Adrian C., Giacca, Mauro, Shankar-Hari, Manu, Mayr, Manuel

“…Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples…”
Get full text

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD by Garcia, Daniel, Hellberg, Kristina, Chaix, Amandine, Wallace, Martina, Herzig, Sébastien, Badur, Mehmet G., Lin, Terry, Shokhirev, Maxim N., Pinto, Antonio F.M., Ross, Debbie S., Saghatelian, Alan, Panda, Satchidananda, Dow, Lukas E., Metallo, Christian M., Shaw, Reuben J.

“…The AMP-activated protein kinase (AMPK) is a highly conserved master regulator of metabolism, whose activation has been proposed to be therapeutically…”
Get full text

The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses by Egholm, Cecilie, Heeb, Lukas E M, Impellizzieri, Daniela, Boyman, Onur

“…Interleukin-4 (IL-4) receptor (IL-4R) signaling plays a pivotal role in type 2 immune responses. Type 2 immunity ensures several host-protective processes such…”
Get full text

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition by Rathert, Philipp, Roth, Mareike, Neumann, Tobias, Muerdter, Felix, Roe, Jae-Seok, Muhar, Matthias, Deswal, Sumit, Cerny-Reiterer, Sabine, Peter, Barbara, Jude, Julian, Hoffmann, Thomas, Boryń, Łukasz M., Axelsson, Elin, Schweifer, Norbert, Tontsch-Grunt, Ulrike, Dow, Lukas E., Gianni, Davide, Pearson, Mark, Valent, Peter, Stark, Alexander, Kraut, Norbert, Vakoc, Christopher R., Zuber, Johannes

“…BET bromodomain inhibitors are being explored as potential therapeutics in cancer; here, AML cells are shown to evade sensitivity to BET inhibition through…”
Get full text

Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer by O'Rourke, Kevin P, Loizou, Evangelia, Livshits, Geulah, Schatoff, Emma M, Baslan, Timour, Manchado, Eusebio, Simon, Janelle, Romesser, Paul B, Leach, Benjamin, Han, Teng, Pauli, Chantal, Beltran, Himisha, Rubin, Mark A, Dow, Lukas E, Lowe, Scott W

“…Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation. Colorectal…”
Get full text

WNT Signaling and Colorectal Cancer by Schatoff, Emma M., Leach, Benjamin I., Dow, Lukas E.

“…The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal…”
Get full text

Life in the Fast Lane: Mammalian Disease Models in the Genomics Era by Dow, Lukas E., Lowe, Scott W.

“…Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a…”
Get full text

Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets by Tang, Fanying, Xu, Duo, Wang, Shangqian, Wong, Chen Khuan, Martinez-Fundichely, Alexander, Lee, Cindy J, Cohen, Sandra, Park, Jane, Hill, Corinne E, Eng, Kenneth, Bareja, Rohan, Han, Teng, Liu, Eric Minwei, Palladino, Ann, Di, Wei, Gao, Dong, Abida, Wassim, Beg, Shaham, Puca, Loredana, Meneses, Maximiliano, de Stanchina, Elisa, Berger, Michael F, Gopalan, Anuradha, Dow, Lukas E, Mosquera, Juan Miguel, Beltran, Himisha, Sternberg, Cora N, Chi, Ping, Scher, Howard I, Sboner, Andrea, Chen, Yu, Khurana, Ekta

“…In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic…”
Get full text

Comprehensive analysis of human IL‐4 receptor subunits shows compartmentalization in steady state and dupilumab treatment by Heeb, Lukas E. M., Boyman, Onur

“…Background Insight into the pathomechanism of atopic diseases demonstrated a pivotal role of the cytokines interleukin‐4 (IL‐4) and IL‐13, which has spurred…”
Get full text

R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine by Han, Teng, Schatoff, Emma M., Murphy, Charles, Zafra, Maria Paz, Wilkinson, John E., Elemento, Olivier, Dow, Lukas E.

“…Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted therapies. Chromosome…”
Get full text