Circulatory collapse in a patient with gastrinoma after metoclopramide administration

A patient who was given metoclopramide for vomiting and diarrhoea developed circulatory collapse with his blood pressure dropping to 50/20 mm Hg. A gastrinoma was diagnosed histologically. The extent of the tumour was defined by octreotide scanning and magnetic resonance imaging. Metoclopramide was...

Full description

Saved in:

Bibliographic Details
Published in:	Hong Kong medical journal = Xianggang yi xue za zhi Vol. 15; no. 6; pp. 478 - 481
Main Authors:	Lau, K K, Chan, K W, Lok, C M, Lam, Angus W S, Lee, Hencher H C, Luk, W F, Mak, Chloe M, Ching, C K, Lo, Joyce, Li, S M, Chan, Albert Y W
Format:	Journal Article
Language:	English
Published:	China Hong Kong Academy of Medicine 01-12-2009
Subjects:	Adolescent Dopamine Antagonists - adverse effects Gastrinoma - complications Gastrinoma - diagnosis Gastrinoma - pathology Humans Male Metoclopramide - adverse effects Nausea - drug therapy Nausea - etiology Neuroendocrine tumors Pancreatic Neoplasms - complications Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - pathology Shock - chemically induced Vomiting - drug therapy Vomiting - etiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A patient who was given metoclopramide for vomiting and diarrhoea developed circulatory collapse with his blood pressure dropping to 50/20 mm Hg. A gastrinoma was diagnosed histologically. The extent of the tumour was defined by octreotide scanning and magnetic resonance imaging. Metoclopramide was again given for colicky abdominal pain and the patient developed circulatory collapse a second time. A laparotomy involving extensive resection of the tumour was performed. The MEN1 mutation was not detected in blood or tumour tissue. Follow-up octreotide scanning did not show any residual tumour. Possible causes for the circulatory collapse are discussed. Our case is probably the first patient with gastrinoma to develop circulatory collapse after being given metoclopramide.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1024-2708 2226-8707